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Suggest transcription factor 7-like 2 is a possible regulator of glucagon-like peptide 1 receptor (zeige GLP1R ELISA Kits) expression in endothelial/smooth muscle cells in diabetic mice.
along with the elevation of miR-17-5p expression in mouse epididymal fat tissue in response to high fat diet consumption, allowed us to suggest that miR-17-5p is among central switches of adipogenic differentiation
TCF7L2 mediates canonic Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling and c-Myc (zeige MYC ELISA Kits) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) to c-Myc (zeige MYC ELISA Kits) axis can be explored for preventing and treating heart failure.
These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population.
Tcf7l2 may be involved in maintenance of stem/progenitor cells properties.
results indicate that miR (zeige MLXIP ELISA Kits)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (zeige TGFB1 ELISA Kits)/Smad (zeige SMAD1 ELISA Kits) and Wnt (zeige WNT2 ELISA Kits) signaling pathway by directly targeting Smad7 (zeige SMAD7 ELISA Kits) and Tcf7l2
Tcf7l2 protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.
Kaiso (zeige ZBTB33 ELISA Kits) and Sox10 (zeige SOX10 ELISA Kits) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.
Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination
Tcf7l2 is regulating proinsulin (zeige INS ELISA Kits) expression directly via Isl1 (zeige ISL1 ELISA Kits), Ins1 and indirectly via MafA (zeige MAFA ELISA Kits), NeuroD1 (zeige NEUROD1 ELISA Kits) and Pdx1 (zeige PDX1 ELISA Kits).
Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.
Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.
In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.
Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.
This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (zeige WNT2 ELISA Kits) signaling in the intestine during zebrafish organogenesis.
XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (zeige CHRD ELISA Kits) in organizer cells at the gastrula stage
regulation of XTcf-4 by canonical wnt (zeige WNT2 ELISA Kits)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (zeige HNF4A ELISA Kits) binding site within its own promoter
In conclusion, TCF7L2 regulates estradiol- or progesterone-modulated islet and hepatic glucose metabolism.
TCF7L2 rs7903146 and 112/112 haplotype of CAPN10 (zeige CAPN10 ELISA Kits) might be associated with gestational diabetes risks.[meta-analysis]
Authors found that KIF23 (zeige KIF23 ELISA Kits) was regulated by TCF-4 (zeige TCF4 ELISA Kits) at transcriptionally level. Therefore, this evidence indicates KIF23 (zeige KIF23 ELISA Kits) over-expression is associated with glioma malignancy and conferred a worse survival time in glioma.
findings indicate that the association between TCF7L2 SNP rs12255372 and HDL (zeige HSD11B1 ELISA Kits)-C may be modified by dietary fat intake in this Asian Indian population
Wnt (zeige WNT2 ELISA Kits) Signaling Pathway Effector TCF7L2 plays a role in Glucose Homeostasis.
The variant in TCF7L2 that increases fasting glucose levels increases between-subject variance, whereas variants in GCK and G6PC2 that increase fasting glucose levels decrease between-subject variance.
The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.
These findings suggest that the rs7903146 locus might exert its enhancer function by interacting with HMGB1 (zeige HMGB1 ELISA Kits) in an allele dependent manner.
TCF7L2 polymorphism is associated with colorectal cancer.
Data show that FERM domain-containing protein 5 (FRMD5) is regulated by both beta-catenin and transcription factor 7-Like 2 protein (TCF7L2) in colon cancer cells.
findings report an independent confirmation of the association of the TCF7L2 (zeige TCF4 ELISA Kits) gene with milk yield and composition traits.
Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (zeige WFS1 ELISA Kits), FTO (zeige FTO ELISA Kits), SLC30A8 (zeige SLC30A8 ELISA Kits), and GCKR (zeige GCKR ELISA Kits), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
transcription factor 7-like 2 (T-cell specific, HMG-box)
, HMG box transcription factor 4
, T-cell factor 4
, T-cell-specific transcription factor 4
, transcription factor 7-like 2
, transcription factor 7-like 2, T-cell specific, HMG-box
, transcription factor tcf4
, T-cell factor XTCF-4A
, transcription factor Tcf4
, T-cell factor-4 variant A
, T-cell factor-4 variant B
, T-cell factor-4 variant C
, T-cell factor-4 variant D
, T-cell factor-4 variant E
, T-cell factor-4 variant F
, T-cell factor-4 variant G
, T-cell factor-4 variant H
, T-cell factor-4 variant I
, T-cell factor-4 variant J
, T-cell factor-4 variant K
, T-cell factor-4 variant L
, T-cell factor-4 variant M
, T-cell factor-4 variant X2