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Human LRP6 ELISA Kit für Sandwich ELISA - ABIN418804
Goetzl, Boxer, Schwartz, Abner, Petersen, Miller, Carlson, Mustapic, Kapogiannis: Low neural exosomal levels of cellular survival factors in Alzheimer's disease. in Annals of clinical and translational neurology 2015
Lrp6 asymmetry is controlled by Wnt (zeige WNT2 ELISA Kits)/PCP (zeige PRCP ELISA Kits) signaling, indicating that this pathway regulates not only planar- but also apicobasal cell polarity.
PTK7 (zeige PTK7 ELISA Kits) and LRP6 proteins physically interact, suggesting that PTK7 (zeige PTK7 ELISA Kits) stabilization of LRP6 protein reciprocally regulates both canonical and noncanonical Wnt (zeige WNT2 ELISA Kits) activities in the embryo.
Results suggest that Rap2 (zeige RAP2A ELISA Kits) acts via TNIK (zeige TNIK ELISA Kits) to regulate the stability of LRP6 receptor for Wnt (zeige WNT2 ELISA Kits) signaling.
The extracellular domains of Lrp5 (zeige LRP5 ELISA Kits)/6 behave as physiologically relevant inhibitors of noncanonical Wnt (zeige WNT2 ELISA Kits) signaling during Xenopus and mouse development in vivo.
Lrp6 plays a critical role in the switch from Wnt (zeige WNT2 ELISA Kits)/PCP (zeige PRCP ELISA Kits) to Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling.
Kremen2 (zeige KREMEN2 ELISA Kits) knockdown specifically reduces LRP6 protein levels in neural crest explants.
Waif1a binds to the Wnt (zeige WNT2 ELISA Kits) coreceptor LRP6 (zeige LRP5 ELISA Kits) and inhibits Wnt (zeige WNT2 ELISA Kits)-induced LRP6 (zeige LRP5 ELISA Kits) internalization into endocytic vesicles, a process that is required for pathway activation.
Results identify GRK5 (zeige GRK5 ELISA Kits)/6 as novel kinases for the single transmembrane receptor LRP6 (zeige LRP5 ELISA Kits) during Wnt (zeige WNT2 ELISA Kits) signaling.
data suggest that LRP6 promotes negative breast cancer cell migration and invasion by regulating the expression and function of S100A4 (zeige S100A4 ELISA Kits) via the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling pathway
sustained activation of Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling due to abrogation of Merlin (zeige NF2 ELISA Kits)-mediated inhibition of LRP6 phosphorylation may be a cause of Neurofibromatosis type II disease.
LRP6 ectodomain becomes highly compact upon complexation with the Wnt (zeige WNT2 ELISA Kits) antagonist Dkk1 (zeige DKK1 ELISA Kits), suggesting a potential role for the ectodomain conformational change in the regulation of receptor oligomerization and signaling.
identify ANGPTL4 (zeige ANGPTL4 ELISA Kits) as a Wnt (zeige WNT2 ELISA Kits) signaling antagonist that binds to syndecans and forms a ternary complex with the Wnt (zeige WNT2 ELISA Kits) co-receptor Lipoprotein receptor-related protein 6
The authors show that folding of the Wnt (zeige WNT2 ELISA Kits) signaling coreceptor LRP6 is promoted by ubiquitination of a specific lysine, retaining it in the ER while avoiding degradation.
Taken together, this study reveals evidence demonstrating a mechanism by which the LPR6/ GSK3beta (zeige GSK3b ELISA Kits)/E2F1 (zeige E2F1 ELISA Kits) axis-upregulated LSH (zeige HELLS ELISA Kits) promoted gliomas.
Structure of the dual-mode Wnt (zeige WNT2 ELISA Kits) regulator Kremen1 (zeige KREMEN1 ELISA Kits) and insight into ternary complex formation with LRP6 and DKK1 (zeige DKK1 ELISA Kits) have been presented.
VAP1 (zeige AOC3 ELISA Kits) cleaved the extracellular region of LRP6 at Glu1196-Leu1197, the C-terminus of the 4th propeller domain. This cleavage removes four inhibito (zeige AOC3 ELISA Kits)ry beta-propeller st (zeige CDH5 ELISA Kits)ructures, resulting in activation of LRP5/6.
We identified a frameshift (c.4594delG, p.Cys1532fs) and a canonical splice-site mutation (c.3398-2A>C, p.?) in LRP6, respectively, in the patient with tooth agenesis (TA) and orofacial clefting (OFC) and in the patient with severe TA only. Mutations in LRP6 cause TA in humans
findings revealed an unrecognized role of Caprin-2 (zeige CAPRIN2 ELISA Kits) in facilitating LRP5 (zeige LRP5 ELISA Kits)/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14 (zeige CDK14 ELISA Kits), Cyclin Y (zeige CCNY ELISA Kits), and LRP5 (zeige LRP5 ELISA Kits)/6.
Lrp6 is the key mediator of Wnt3a (zeige WNT3A ELISA Kits) signaling in osteoblasts and Lrp5 (zeige LRP5 ELISA Kits) played a less significant role in mediating Wnt3a (zeige WNT3A ELISA Kits) signaling.
VAP1 (zeige AOC3 ELISA Kits) cleaved recombinant mouse LRP6, producing a 140-kDa fragment. An antibody against a peptide including the LRP6-cleavage site inhibited VAP1 (zeige AOC3 ELISA Kits)-induced VE-cadherin (zeige CDH5 ELISA Kits) relocation and disruption of cell-cell adhesions and blocked haemorrhage in mice in vivo.
we identified Lrp6, the gene encoding the coreceptor to Frizzled in the Wnt (zeige WNT2 ELISA Kits) pathway, as a potential negative regulator of precursor proliferation. Overexpression and siRNA silencing confirmed the regulatory role of Lrp6
These results revealed a new role of the canonical Lrp5 (zeige LRP5 ELISA Kits)/6-beta-catenin (zeige CTNNB1 ELISA Kits) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
Data (including data from studies in knockout/transgenic mice) suggest Lrp6 is required for suppression of Sost (sclerostin (zeige SOST ELISA Kits)) expression by parathyroid hormone (zeige PTH ELISA Kits) (here, human PTH (zeige PTH ELISA Kits) peptide 1-34); LRP6 regulates osteocytes expression of histone deacetylases.
Lrp5 (zeige LRP5 ELISA Kits) binds to Frizzled, preventing Frz-regulated non-canonical Wnt (zeige WNT2 ELISA Kits) pathway activation and further non-canonical pathway-mediated tumour metastasis.
Wt1 (zeige WT1 ELISA Kits) expression levels in podocytes regulate Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling through modulating the endocytic fate of LRP6, and this indicates a potential target for the therapy of CKD.
N-cadherin (zeige CDH2 ELISA Kits) modulates Lrp6/PTHR1 (zeige PTH1R ELISA Kits) interaction, restraining the intensity of parathyroid hormone (zeige PTH ELISA Kits)-induced beta-catenin (zeige CTNNB1 ELISA Kits) signaling
LRP6 restrains vascular smooth muscle lineage noncanonical signals that promote osteochondrogenic differentiation, mediated in part via USF1 (zeige USF1 ELISA Kits)- and arginine methylation-dependent relays.
Urotensin II (zeige UTS2 ELISA Kits) inhibited the proliferation of cardiac side population cells by JNK (zeige MAPK8 ELISA Kits)/LRP6 signalling during pressure overload.
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
low density lipoprotein receptor-related protein 6
, lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6
, low-density lipoprotein receptor-related protein 6-like
, low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6
, low density lipoprotein-related protein 6