anti-LRP5 (LRP5) Antikörper

Bezeichnung:
anti-Low Density Lipoprotein Receptor-Related Protein 5 Antikörper (LRP5)
Auf www.antikoerper-online.de finden Sie aktuell 128 Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Antikörper von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen LRP5 Kits (13) und LRP5 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 154 LRP5 Produkte verfügbar.
Synonyme:
BMND1, EVR1, EVR4, HBM, LR3, LRP5, lrp5-A, LRP6, LRP7, mKIAA4142, OPPG, OPS, OPTA1, VBCH2, Xlrp5

Meistgesuchte Reaktivitäten zu anti-LRP5 (LRP5) Antikörper

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anti-Human LRP5 Antikörper:

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anti-Rat (Rattus) LRP5 Antikörper:

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Am meisten referenzierte anti-LRP5 Antikörper

  1. Human Polyclonal LRP5 Primary Antibody für EIA, WB - ABIN953209 : Abramowitz, Muntner, Coco, Southern, Lotwin, Hostetter, Melamed: Serum alkaline phosphatase and phosphate and risk of mortality and hospitalization. in Clinical journal of the American Society of Nephrology : CJASN 2010 (PubMed)
    Zeige alle 4 Referenzen für 953209

  2. Human Monoclonal LRP5 Primary Antibody für FACS, ELISA - ABIN969535 : Urano, Shiraki, Usui, Sasaki, Ouchi, Inoue: A1330V variant of the low-density lipoprotein receptor-related protein 5 (LRP5) gene decreases Wnt signaling and affects the total body bone mineral density in Japanese women. in Endocrine journal 2009 (PubMed)
    Zeige alle 2 Referenzen für 969535

  3. Human Polyclonal LRP5 Primary Antibody für WB - ABIN127323 : Del Valle-Pérez, Arqués, Vinyoles, de Herreros, Duñach: Coordinated action of CK1 isoforms in canonical Wnt signaling. in Molecular and cellular biology 2011 (PubMed)
    Zeige alle 2 Referenzen für 127323

  4. Human Polyclonal LRP5 Primary Antibody für IHC, ELISA - ABIN185410 : He, Semenov, Tamai, Zeng: LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. in Development (Cambridge, England) 2004 (PubMed)
    Zeige alle 2 Referenzen für 185410

  5. Human Monoclonal LRP5 Primary Antibody für ELISA, WB - ABIN517568 : Kim, Goel, Alexander: Differentiation generates paracrine cell pairs that maintain basaloid mouse mammary tumors: proof of concept. in PLoS ONE 2011 (PubMed)

Weitere Antikörper gegen LRP5 Interaktionspartner

Xenopus laevis Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Interaktionspartner

  1. The extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt (zeige WNT2 Antikörper) signaling during Xenopus and mouse development in vivo.

Zebrafish Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Interaktionspartner

  1. Data show that in zebrafish, lrp5 also controls cell migration during early morphogenetic processes and contributes to shaping the craniofacial skeleton.

Human Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Interaktionspartner

  1. Among the detected mutations, LRP5 accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (zeige NDP Antikörper) (3/31, 9.7%), FZD4 (zeige FZD4 Antikörper) (2/31, 6.5%), TSPAN12 (zeige TSPAN12 Antikörper) (1/31, 3.2%), and KIF11 (zeige KIF11 Antikörper) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  2. wild-type and all five mutant LRP5 proteins were assayed for the ability to activate the Norrin (zeige NDP Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway by established luciferase reporter assays, and all mutants failed to activate the pathway.

  3. findings revealed an unrecognized role of Caprin-2 (zeige CAPRIN2 Antikörper) in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14 (zeige CDK14 Antikörper), Cyclin Y (zeige CCNY Antikörper), and LRP5/6.

  4. This study did not identify LRP5 polymorphisms as a risk factor for osteoporosis in Thai menopausal women.

  5. We identified four novel LRP5 missense mutations in these FEVR (zeige NDP Antikörper) families: c.C1042T (p.R348W), c.G1141A (p.D381N), c.C1870T (p.R624W), and c.A4550G (p.Y1517C). All four of these LRP5 mutations led to significant reduction of enzymatic activity with response to NORRIN (zeige NDP Antikörper). Our findings expand the mutational spectrum of FEVR (zeige NDP Antikörper) in the Indian population and provide some guidelines in clinical diagnosis.

  6. In this study, the splice site mutation c.2827thorn1G > A found in LRP5 (603506) gene is thought to cause microphthalmia in this family.

  7. A genetic evaluation of the known genes associated with familial exudative vitreoretinopathy (FEVR (zeige NDP Antikörper)) revealed a novel variant in the LRP5 gene that co-segregated with the phenotype in the family.

  8. Meta-analysis indicates that the LRP5 Ala1330Val polymorphism may not be correlated with fracture susceptibility.

  9. Independently or combined with APOE (zeige APOE Antikörper), LRP5 polymorphisms may lead to dyslipidemia and are associated with generalized aggressive periodontitis. Dyslipidemia may be a risk indicator for generalized aggressive periodontitis in the Chinese population. Furthermore, two LRP5 polymorphisms (rs682429 and rs312016) might be useful for identifying subjects at higher risk of generalized aggressive periodontitis.

  10. miR (zeige MLXIP Antikörper)-23a plays an inhibitory role in osteogenic differentiation of hBMSCs, which may act by targeting LRP5

Mouse (Murine) Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Interaktionspartner

  1. we revealed miR (zeige MLXIP Antikörper)-375-3p negatively regulated osteogenesis by targeting LRP5 and beta-catenin (zeige CTNNB1 Antikörper)

  2. lung myeloid cells are responsive to Lrp5/beta-catenin (zeige CTNNB1 Antikörper) signaling, leading to differentiation of an alveolar macrophage subtype that antagonizes the resolution of lung fibrosis.

  3. LRP5 is a novel anti-inflammatory macrophage marker that positively regulates migration, phagocytosis, lipid uptake and metabolism.

  4. These results revealed a new role of the canonical Lrp5/6-beta-catenin (zeige CTNNB1 Antikörper) pathway in regulating the morphogenesis of the cerebellum during postnatal development.

  5. LRP5 function in mice causes retinal hypovascularization during development as well as retinal neovascularization in adulthood with disorganized and leaky vessels.

  6. Lrp5 is required for glucose uptake, and glucose uptake regulates the growth rate of mammary epithelial cells in culture.

  7. Data show that LDL receptor (zeige LDLR Antikörper)-related protein 5 (zeige CAPS Antikörper) (LRP5) gain-of-function mutations do not activate beta-catenin (zeige CTNNB1 Antikörper) signaling in osteoblasts.

  8. These in vivo data support in vitro studies regarding the mechanism of HBM-causing mutations, and imply that HBM LRP5 receptors differ in their relative sensitivity to inhibition by SOST (zeige SOST Antikörper) and DKK1 (zeige DKK1 Antikörper).

  9. Lrp5 A214V and G171V were partially or fully protected from the bone loss that normally results frommechanical disuse using two models, tail suspension and Botulinum toxin-induced muscle paralysis, in two different Lrp5 HBM knock-in mouse models.

  10. In hypercholesterolemia LRP5(-/-) mice Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway was shut down. An antiatherogenic role for LRP5 was demonstrated as HC LRP5(-/-) mice developed larger aortic atherosclerotic lesions than WT mice.

LRP5 Antigen-Profil

Beschreibung des Gens

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

Alternative names and synonyms associated with LRP5

  • low density lipoprotein receptor-related protein 5 (LRP5) Antikörper
  • low density lipoprotein receptor-related protein 5 (lrp5) Antikörper
  • low density lipoprotein receptor-related protein 5 (LOC100220027) Antikörper
  • low density lipoprotein receptor-related protein 5 (Lrp5) Antikörper
  • BMND1 Antikörper
  • EVR1 Antikörper
  • EVR4 Antikörper
  • HBM Antikörper
  • LR3 Antikörper
  • LRP5 Antikörper
  • lrp5-A Antikörper
  • LRP6 Antikörper
  • LRP7 Antikörper
  • mKIAA4142 Antikörper
  • OPPG Antikörper
  • OPS Antikörper
  • OPTA1 Antikörper
  • VBCH2 Antikörper
  • Xlrp5 Antikörper

Bezeichner auf Proteinebene für LRP5

Lipoprotein Receptor Related Protein 5 , low density lipoprotein receptor-related protein 5 , low-density lipoprotein receptor-related protein 5 , low-density lipoprotein receptor-related protein 5-like , LRP-5 , low density lipoprotein receptor-related protein 7 , LRP-7 , low-density lipoprotein receptor-related protein 7

GENE ID SPEZIES
100147353 Equus caballus
100009566 Oryctolagus cuniculus
373722 Xenopus laevis
451380 Pan troglodytes
568518 Danio rerio
100189542 Papio anubis
100220027 Taeniopygia guttata
100406268 Callithrix jacchus
100473379 Ailuropoda melanoleuca
100491803 Xenopus (Silurana) tropicalis
100548748 Meleagris gallopavo
4041 Homo sapiens
16973 Mus musculus
293649 Rattus norvegicus
423114 Gallus gallus
100306933 Canis lupus familiaris
534450 Bos taurus
100524299 Sus scrofa
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