anti-Maus LEF1 Antikörper für Immunofluorescence

Recommended LEF1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Lymphoid Enhancer-Binding Factor 1 (LEF1) Antikörper
  • LEF1
  • 3000002B05
  • AI451430
  • Lef-1
  • LEF-1
  • TCF10
  • TCF1ALPHA
  • TCF7L3
  • lymphoid enhancer-binding factor 1
  • lymphocyte enhancer binding factor 1
  • lymphoid enhancer binding factor 1
  • lymphoid enhancer factor XLEF-1B
  • LEF1
  • LOC100352691
  • lef1
  • Lef1
Epitop
HMG Binding Domain
15
13
13
9
8
6
6
6
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
128
41
32
11
7
7
5
5
4
4
4
4
3
2
1
1
Wirt
Maus
57
51
16
5
Klonalität
Monoklonal
Konjugat
Dieser LEF1 Antikörper ist unkonjugiert
3
3
3
3
3
3
Applikation
Immunofluorescence (IF), Western Blotting (WB)
115
67
21
17
10
7
5
3
2
2
2
1
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN264381
407,00 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN221435 ICC FACS IF IP WB Rabbit IgG Pro82 Anmelden zum Anzeigen
1 ABIN264379 IF IHC (p) WB Mouse IgG1 Anmelden zum Anzeigen REMB1

General

Antigen Lymphoid Enhancer-Binding Factor 1 (LEF1) Antikörper
Epitop HMG Binding Domain
(15), (13), (13), (9), (8), (6), (6), (6), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus
(128), (41), (32), (11), (7), (7), (5), (5), (4), (4), (4), (4), (3), (2), (1), (1)
Wirt Maus
(57), (51), (16), (5)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser LEF1 Antikörper ist unkonjugiert
(3), (3), (3), (3), (3), (3)
Applikation Immunofluorescence (IF), Western Blotting (WB)
(115), (67), (21), (17), (10), (7), (5), (3), (2), (2), (2), (1), (1), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-LEF1 Antikörper

Target Details LEF1 Anwendungsinformationen Handhabung ProductDetails: References for anti-LEF1 antibody (ABIN264381) Bilder
Spezifität REMB6 recognizes the High Mobility Group DNA domain of LEF-1.
Produktmerkmale Synonyms: Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha,TCF1-alpha
Reinigung Purified
Immunogen Full-length recombinant LEF-1 protein. Genename: LEF1
Klon REMB6
Isotyp IgG1

Target Details LEF1

Produktdetails anti-LEF1 Antikörper Anwendungsinformationen Handhabung ProductDetails: References for anti-LEF1 antibody (ABIN264381) Bilder zurück nach oben
Antigen
Andere Bezeichnung LEF1 (LEF1 Antibody Abstract)
Hintergrund Lymphoid Enhancer Factor-1 is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF-1, TCF-1, TCF-3 and TCF-4). These factors play a crucial role in WNT/WIngless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer.LEF-1 is expressed during development in many different differentiating tissues, and in a few tissues after birth. LEF-1 expression is required for proper development of breast, teeth, hair, whiskers and the trigeminal nerve. It is redundant with TCF-1 (for T Cell Factor-1) for correct development of T lymphocytes in the thymus. LEF-1 is a 399 amino acid protein that appears as a cluster of polypeptides ranging in size between 55-57 kD on SDS-PAGE analysis. Alternative splice forms of LEF-1 and other LEF/TCF family members have been identified, but the expression pattern and relative abundance of these alternative forms have not been well studied. They can appear on westerns as smaller immunoreactive forms.Synonyms: LEF-1, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1-alpha
Gen-ID 51176
UniProt Q9UJU2
Forschungsgebiet Transcription Factors, Wnt, Lineage Markers, Wnt Signaling
Pathways WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding

Anwendungsinformationen

Produktdetails anti-LEF1 Antikörper Target Details LEF1 Handhabung ProductDetails: References for anti-LEF1 antibody (ABIN264381) Bilder zurück nach oben
Applikationshinweise Western Blot: 1-5 μg/mLImmunofluorescence on Paraformaldehyde-Fixed Cells: 1 μg/mL (1/1000). Positive Control: Jurkat cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-LEF1 Antikörper Target Details LEF1 Anwendungsinformationen ProductDetails: References for anti-LEF1 antibody (ABIN264381) Bilder zurück nach oben
Buffer PBS, 0.08 % Sodium Azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Haltbarkeit 12 months

ProductDetails: References for anti-LEF1 antibody (ABIN264381)

Produktdetails anti-LEF1 Antikörper Target Details LEF1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Hsu, Galceran, Grosschedl: "Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin." in: Molecular and cellular biology, Vol. 18, Issue 8, pp. 4807-18, 1998

Bilder

Produktdetails anti-LEF1 Antikörper Target Details LEF1 Anwendungsinformationen Handhabung ProductDetails: References for anti-LEF1 antibody (ABIN264381) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (HMG Binding Domain) antibody (ABIN264381) anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (HMG Binding Domain) antibody
Immunofluorescence (IF) image for anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (HMG Binding Domain) antibody (ABIN264381) anti-Lymphoid Enhancer-Binding Factor 1 (LEF1) (HMG Binding Domain) antibody (Image 2)