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Enhancer of zeste homolog 2 (EZH2 (zeige EZH2 ELISA Kits)) expression is positively correlated with the expression of Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling and negatively correlated with the expression of GSK-3beta and TP53 (zeige TP53 ELISA Kits) in cervical cancer tissues.
ZIP9 (zeige SLC39A9 ELISA Kits) expression affects phosphorylation states of GSK-3beta.
High GSK3 expression is associated with prostate cancer.
Cytoplasmic aryl hydrocarbon receptor (zeige AHR ELISA Kits) regulates glycogen synthase kinase 3 beta in non-small cell lung cancer cells.
Findings show that FGF19 (zeige FGF19 ELISA Kits) provides a cytoprotective role against ER stress by activating a FGFR4 (zeige FGFR4 ELISA Kits)-GSK3beta-Nrf2 (zeige GABPA ELISA Kits) signaling cascade, suggesting targeting this signaling node as a candidate therapeutic regimen for hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) management.
data show that the GSK3B-FOXO3 (zeige FOXO3 ELISA Kits) pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R (zeige IGF1R ELISA Kits) after partial hepatectomy.
ablation of Glut1 (zeige SLC2A1 ELISA Kits) attenuated apoptosis and increased drug resistance via upregulation of p-Akt (zeige AKT1 ELISA Kits)/p-GSK-3beta (Ser9)/beta-catenin (zeige CTNNB1 ELISA Kits)/survivin (zeige BIRC5 ELISA Kits).
frequent upregulation of MIF (zeige AMH ELISA Kits) is implicated in the development and progression of esophageal squamous cell carcinoma (ESCC).
TRIM9s undergoes Lys (zeige LYZ ELISA Kits)-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1 (zeige TBK1 ELISA Kits), leading to the activation of IRF3 (zeige IRF3 ELISA Kits) signaling.
Data suggest that NOX5 (zeige NOX5 ELISA Kits) expression in melanoma cells could contribute to cell proliferation due, in part, to the generation of high local concentrations of extracellular ROS (zeige ROS1 ELISA Kits) that modulate multiple pathways that regulate HIF-1alpha (zeige HIF1A ELISA Kits) and networks that signal through Akt (zeige AKT1 ELISA Kits)/GSK3beta/p27(Kip1 (zeige CDKN1B ELISA Kits)) .
This study demonstrates the neuroprotective effect of TSG (zeige TWSG1 ELISA Kits) on APP (zeige APP ELISA Kits) expression, suggesting that TSG (zeige TWSG1 ELISA Kits) may be beneficial for AD prevention and treatment.
GSK3 catalyzes two previously unreported phosphorylation events at Ser(476) and Ser(480) of Cbl-b. The PI3K-PKB-GSK-3 pathway is a novel regulatory axis that is important for controlling the decision between T cell activation and tolerance via Cbl-b.
GSK-3 plays a significant role in astrocyte development and behavioral control in mice.
Study of GSK3b inhibitors SB415286 and SB216763 to improve osteoblastic differentiation on microstructured titanium.
identify GSK-3beta as a newly identified target for amelioration of empyema-related pleural fibrosis and provide a strong rationale for further investigation of GSK-3beta signaling in the control of MesoMT and pleural injury
it is suggested that Notch-1 (zeige NOTCH1 ELISA Kits), NF-kappaB (zeige NFKB1 ELISA Kits)/p65 (zeige NFkBP65 ELISA Kits) and GSK-3beta operate in synergy to inhibit microglia activation
Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a (zeige GSK3a ELISA Kits) phosphorylate splicing factors (Rbm8a (zeige RBM8A ELISA Kits), Srsf9 (zeige SFRS9 ELISA Kits), and Psf (zeige IL-3 ELISA Kits)) and nucleolar proteins (Npm1 (zeige GJA1 ELISA Kits) and Phf6 (zeige PHF6 ELISA Kits)); Gsk3b/Gsk3a (zeige GSK3a ELISA Kits) are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3 (zeige GSK3a ELISA Kits); Rbm8a (zeige RBM8A ELISA Kits) = RNA binding motif protein 8a (zeige RBM8A ELISA Kits); Srsf9 (zeige SFRS9 ELISA Kits) = splicing factor (zeige SLU7 ELISA Kits), arginine-serine-rich 9; Psf (zeige IL-3 ELISA Kits) = replication protein Psf (zeige IL-3 ELISA Kits); Npm1 (zeige GJA1 ELISA Kits) = nucleophosmin 1 (zeige NPM1 ELISA Kits); Phf6 (zeige PHF6 ELISA Kits) = PHD finger protein 6 (zeige PHF6 ELISA Kits))
Tideglusib significantly reduced cerebral infarct volume at both 24h and 7days after HI injury. Tideglusib also increased phosphorylated GSK-3beta(Ser9) and Akt (zeige AKT1 ELISA Kits)(Ser473)
Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT (zeige AKT1 ELISA Kits)/GSK3beta signaling axis at cilia in SHH (zeige SHH ELISA Kits)-dependent medulloblastoma that is regulated by INPP5E (zeige INPP5E ELISA Kits) to maintain tumor cell cilia, promote SHH (zeige SHH ELISA Kits) signaling and thereby medulloblastoma progression.
These results suggest that maintenance of sperm motility and acrosome reaction timing are mediated by PKA through the regulation of GSK-3 beta activity.
GSK3B and phosphorylated GSK3B regulate milk synthesis and proliferation dairy cow mammary epithelial cells.
GSK3B serine phosphorylation was positively correlated with embryo development
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
IGF-I (zeige IGF1 ELISA Kits) down-regulated functional IGF-I receptor (zeige IGF1R ELISA Kits) via GSK-3beta inhibition and mTOR (zeige FRAP1 ELISA Kits) activation; constitutive activity of GSK-3beta maintained IGF-I receptor (zeige IGF1R ELISA Kits) level in nonstimulated cells.
These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated phosphorylation of SH-binding proteins, including MBP (zeige MBP ELISA Kits) and tau protein.
cAMP/PKA regulation of GSK3beta/beta-catenin (zeige CTNNB1 ELISA Kits) signaling contributes to the increase in progesterone production in corpus luteum.
Five different isoforms of GSK3beta identified from porcine tissues, splice variants exhibit differential activity towards glycogen synthase.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of GSK3beta activity which can lead to activation of the downstream signaling through beta-catenin (zeige CTNNB1 ELISA Kits)
There was no correlation of infarct size with expression or phosphorylation of p70S6K (zeige RPS6KB1 ELISA Kits) or GSK3beta in ischemic postconditioning.
Both active and inactive forms of Gsk3b mediate the cooperative signaling during angiogenesis in zebrafish embryos.
a novel negative, Gsk3beta-independent control mechanism of beta-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation.
The regulatory target of Wnts and Igfs, GSK3beta, is inefficiently inactivated in male fin regenerates compared with females. Pharmacological inhibition of GSK3 in males increases blastemal proliferation and restores regenerative pattern.
2-OST (zeige HS2ST1 ELISA Kits) functions within the Wnt (zeige WNT2 ELISA Kits) pathway, downstream of Wnt (zeige WNT2 ELISA Kits) ligand signaling and upstream of Gsk3beta and beta-catenin (zeige CTNNB1 ELISA Kits) intracellular localization and function
Data show that GSK-3beta inhibition was sufficient to stimulate MG dedifferentiation and the formation of multipotent retinal progenitors that were capable of differentiating into all major retinal cell types.
GSK3alpha, but not GSK3beta, is necessary in cardiomyocyte survival
Gsk3b regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (zeige SGPL1 ELISA Kits)) factor activity.
A newly developed highly active GSK3beta inhibitor AR-534, reduced human TAU phosphorylation in TAU transgenic zebrafish.
lycogen synthase kinase-3 (GSK3) was identified as a substrate of protein kinase c delta (zeige PKCd ELISA Kits) in breast cancer cells.
Novel roles for Plk (zeige PLK1 ELISA Kits) and GSK3 regulation of ADAM13 (zeige ADAM33 ELISA Kits) function in cranial neural crest cell migration.
Interaction with Snail1 (zeige SNAI1 ELISA Kits)/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
These data suggest that the interactions of beta-catenin (zeige CTNNB1 ELISA Kits) with alpha-catenin (zeige CTNNA1 ELISA Kits) and GSK-3beta exert opposing effects on the terminal projections of ventral optic axons.
Our findings demonstrated that lovastatin restored LRRK2 (zeige LRRK2 ELISA Kits)-G2019S neurite degeneration by augmenting Akt (zeige AKT1 ELISA Kits)/NRF2 (zeige NFE2L2 ELISA Kits) pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2 (zeige LRRK2 ELISA Kits)-G2019S parkinsonism.
Mitochondrial function leads to extensive glycogen (zeige GYS1 ELISA Kits) accumulation late in oogenesis and is required for the developmental competence of the oocyte. Decreased insulin (zeige INS ELISA Kits) signaling initiates ETC remodeling and mitochondrial respiratory quiescence through glycogen synthase kinase 3 (zeige GSK3a ELISA Kits) (GSK3).
Drosophila-based findings highlight an apical role for Hyd (zeige UBR5 ELISA Kits) and Sgg in initiating Hedgehog (zeige SHH ELISA Kits) signalling, which could also be evolutionarily conserved in mammals
Results show that downregulation of GSK3 promotes synapse formation in Drosophila neurons. However in rats hippocampal neurons, GSK3 inhibition yields to decrease of synapses in young neurons culture and the opposite in aged culture.
upregulation of Nebula/DSCR1 is neuroprotective in the presence of APP upregulation and provides evidence for calcineurin inhibition as a novel target for therapeutic intervention in preventing axonal transport impairments associated with AD
The Par-1 (zeige F2R ELISA Kits)/GSK-3/Slimb pathway plays important roles in limiting the amount of pole plasm posteriorly and in degrading any mislocalized Oskar that results from leaky translational repression.
GSK-3 is required for biderectional axonal transport.
findings suggest a mechanism in which Shaggy/GSK-3beta activates calcineurin through Sarah phosphorylation on egg activation in Drosophila
roles for the kinases GSK3 and aPKC in cellular alignment, asymmetric protein distribution, and adhesion during the development of this polarized tissue
Insulin (zeige INS ELISA Kits) induces Myc (zeige MYC ELISA Kits) protein accumulation in Drosophila S2 cells, which correlates with a decrease in the activity of glycogen synthase kinase 3-beta (GSK3beta ) a kinase that is responsible for Myc (zeige MYC ELISA Kits) protein degradation.
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, GSK3beta isoform
, glycogen synthase kinase-3 beta
, serine/threonine-protein kinase GSK3B
, factor A
, glycogen synthase kinase 3 beta variant 1
, glycogen synthase kinase 3 beta variant 2
, glycogen synthase kinase 3 beta variant 3
, glycogen synthase kinase 3 beta variant 4
, intracellular kinase
, CG2621 gene product from transcript CG2621-RA
, GSK-3 kinase
, Protein zeste-white 3
, Shaggy/Glycogen synthase kinase 3
, Shaggy/Zeste-white-3/Glycogen synthase kinase 3beta
, Zw3 kinase
, glycogen synthase Kinase-3
, glycogen synthase kinase 3
, glycogen synthase kinase 3Beta
, glycogen synthase kinase-3beta
, shaggy-zeste white 3
, shaggy/zeste-white 3
, zest-white 3
, zeste white 3
, zeste white-3
, zeste white3
, zeste-white 3