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Authors conclude that the planar cell polarity (PCP (zeige PRCP ELISA Kits)) pathway contributes significantly to the motility and hence the invasiveness of glioblastoma multiforme (GBM) cells, and that Nrdp1 (zeige RNF41 ELISA Kits) acts as a negative regulator of PCP (zeige PRCP ELISA Kits) signaling by inhibiting Dvl (zeige DVL2 ELISA Kits) through a novel polyubiquitination mechanism.
The DEP (zeige ZDHHC21 ELISA Kits) domain of Dishevelled (zeige DVL2 ELISA Kits) undergoes a conformational switch, from monomeric to swapped dimer, to trigger DIX domain-dependent polymerization and signaling to beta-catenin (zeige CTNNB1 ELISA Kits).
two mutually exclusive functions of the DEP (zeige ZDHHC21 ELISA Kits) domain in Wnt (zeige WNT2 ELISA Kits) signal transduction - binding to Frizzled to recruit Dishevelled (zeige DVL2 ELISA Kits) to the receptor complex, is reported.
we show that Wnt5a (zeige WNT5A ELISA Kits) rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (zeige POLR1C ELISA Kits) (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome.
Data show that dishevelled (zeige DVL2 ELISA Kits) proteins DVL1, 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
The secreted frizzled-related protein (zeige SFRP2 ELISA Kits) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
Data show that receptor for activated C kinase 1 (RACK1 (zeige GNB2L1 ELISA Kits)) interacts with Dishevelled (Dvl (zeige DVL2 ELISA Kits)) proteins and promotes their lysosomal degradation, and this effect is enhanced by autophagy induction.
TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVLl.
Specific -1 frameshift variants in the penultimate exon of DVL1 cause autosomal-dominant Robinow syndrome.
Results show that coexpression of IQGAP1 (zeige IQGAP1 ELISA Kits) and Dvl (zeige DVL2 ELISA Kits) in the cytoplasm and nucleus was correlated with the lymph nodal metastase and poor prognosis of non-small cell lung cancer.
Data show that the peptide binding pocket of the Dishevelled 1 (Dvl1) PDZ domain (zeige INADL ELISA Kits) is stabilized upon CXXC finger 5 protein (CXXC5 (zeige CXXC5 ELISA Kits)) binding.
Here we show that the peptide-binding pocket of the Dvl PDZ domain (zeige INADL ELISA Kits) can be occupied by Dvl's own highly conserved C-terminus, inducing a closed conformation.
The interaction of Dvl1 with Syt-1 (zeige SYT1 ELISA Kits), which is regulated by Wnts, modulates neurotransmitter release.
findings indicate that Dvl-1 may be an underlying participant of oxidative stress induced (zeige SQSTM1 ELISA Kits) by selenium deficiency
These results support a novel cell-autonomous postsynaptic role for Dact1 (zeige DACT1 ELISA Kits), in cooperation with Dishevelled-1 and possibly Disrupted in Schizophrenia-1 (zeige DISC1 ELISA Kits), in the formation of synapses on cortical interneuron dendrites.
we show that Dvl-1 expression is restricted to OSNs in the dorsal recess of the nasal cavity, and labels a unique subpopulation of glomeruli. Dvl-2 (zeige DVL2 ELISA Kits) and Dvl-3 (zeige DVL3 ELISA Kits) have a widespread distribution in both the olfactory epithelium and olfactory bulb .
Fuzzy appears to control subcellular localization of the core PCP (zeige BMP1 ELISA Kits) protein Dishevelled (zeige DVL2 ELISA Kits), recruiting it to Rab8 (zeige RAB8A ELISA Kits)-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP (zeige BMP1 ELISA Kits) signaling
A Wnt5a (zeige WNT5A ELISA Kits)--> Dvl PCP (zeige BMP1 ELISA Kits) signaling cascade may regulate actin polymerization and protrusive cell behavior in the caudal (zeige CAD ELISA Kits) splanchnic mesoderm to promote second heart field deployment, outflow tract lengthening and cardiac looping.
Findings indicate that Daple (zeige CCDC88C ELISA Kits) interacts with Dishevelled (zeige DVL2 ELISA Kits) to direct the Dishevelled (zeige DVL2 ELISA Kits)/protein kinase (zeige CDK7 ELISA Kits) lambda protein complex to activate Rac (zeige AKT1 ELISA Kits), which in turn mediates the non-canonical Wnt (zeige WNT2 ELISA Kits) signalling pathway required for cell migration.
The antagonistic functions of Vangl2 (zeige VANGL2 ELISA Kits) and Dvl1 allow sharpening of planar cell polarity signaling locally on the tips of the filopodia to sense directional cues, Wnts, eventually causing turning of growth cones.
Different Dvl (zeige DVL2 ELISA Kits) proteins (Dvl1, Dvl2 (zeige DVL2 ELISA Kits), Dvl3 (zeige DVL3 ELISA Kits)) and the composition of dishevelled (zeige DVL2 ELISA Kits)-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (zeige WNT2 ELISA Kits) signaling in Xenopus gastrulation.
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
DSH homolog 1
, dishevelled 1 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 1
, segment polarity protein dishevelled homolog DVL-1
, dishevelled 1
, dishevelled, dsh homolog 2, like