anti-Human DKK2 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended DKK2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) Antikörper
  • DKK-2
  • Dkk4
  • dickkopf WNT signaling pathway inhibitor 2
  • dickkopf WNT signaling pathway inhibitor 1
  • dickkopf homolog 2 (Xenopus laevis)
  • dickkopf 2 homolog (Xenopus laevis)
  • dickkopf-related protein 2-like
  • DKK2
  • Dkk1
  • Dkk2
  • LOC100519672
Epitop
C-Term
29
18
6
5
5
4
1
1
1
1
1
Reaktivität
Human
83
27
19
5
4
3
2
2
2
2
2
Wirt
Kaninchen
72
16
Klonalität
Polyklonal
Konjugat
Dieser DKK2 Antikörper ist unkonjugiert
8
7
5
5
5
4
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
77
51
30
9
1
1
1
1
1
Hersteller
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Bilder

Produktnummer ABIN357070
$ 390.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN357069 EIA IHC (p) WB Rabbit Ig N-Term Anmelden zum Anzeigen Polyclonal 3
1 ABIN388353 IHC (p) WB Rabbit Ig AA 31-62, N-Term Anmelden zum Anzeigen Polyclonal 2
1 ABIN1493908 IHC (p) WB Rabbit AA 124-173 Anmelden zum Anzeigen Polyclonal
1 ABIN388354 IHC (p) WB Rabbit Ig AA 225-251, C-Term Anmelden zum Anzeigen Polyclonal
1 ABIN5538399 IHC (p) WB Rabbit Ig Fraction AA 31-62, N-Term Anmelden zum Anzeigen Polyclonal
1 ABIN5538400 IHC (p) WB Rabbit Ig Fraction AA 225-251, C-Term Anmelden zum Anzeigen Polyclonal
1 ABIN2962537 IHC (p) WB Rabbit AA 31-62, N-Term Anmelden zum Anzeigen Polyclonal
1 ABIN1840807 IHC (p) WB Rabbit AA 225-251 Anmelden zum Anzeigen Polyclonal
1 ABIN2598555 IHC (p) WB Rabbit AA 31-62 Anmelden zum Anzeigen Polyclonal

General

Antigen Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) Antikörper
Epitop C-Term
(29), (18), (6), (5), (5), (4), (1), (1), (1), (1), (1)
Reaktivität Human
(83), (27), (19), (5), (4), (3), (2), (2), (2), (2), (2)
Wirt Kaninchen
(72), (16)
Klonalität
Polyklonal
Konjugat Dieser DKK2 Antikörper ist unkonjugiert
(8), (7), (5), (5), (5), (4)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(77), (51), (30), (9), (1), (1), (1), (1), (1)
Pubmed 3 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-DKK2 Antikörper

Target Details DKK2 Anwendungsinformationen Handhabung Referenzen für anti-DKK2 Antikörper (ABIN357070) Bilder
Spezifität This antibody detects DKK2 at C-term.
Reinigung Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This polyclonal antibody was raised against a peptide corresponding to a sequence selected for the C-terminal region of human DKK2.
Isotyp Ig

Target Details DKK2

Produktdetails anti-DKK2 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-DKK2 Antikörper (ABIN357070) Bilder zurück nach oben
Antigen
Andere Bezeichnung Dickkopf-2 (DKK2) (DKK2 Antibody Abstract)
Hintergrund The 259-amino acid DKK2 protein, like DKK1, DKK3, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cys residues each. The second cys region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed expression of 4.0- and 4.5-kb DKK2 transcripts in heart, brain, skeletal muscle, and lung. Western blot analysis showed that DKK2 is secreted as a 15- to 17-kD protein. Functional analysis determined that DKK2 does not block Xenopus Wnt8 induction of a secondary axis in frog embryos.Synonyms: Dickkopf-related protein 2, Dkk-2
Molekulargewicht 28447 Da
Gen-ID 27123, 9606
UniProt Q9UBU2
Pathways WNT Signalweg

Anwendungsinformationen

Produktdetails anti-DKK2 Antikörper Target Details DKK2 Handhabung Referenzen für anti-DKK2 Antikörper (ABIN357070) Bilder zurück nach oben
Applikationshinweise ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-DKK2 Antikörper Target Details DKK2 Anwendungsinformationen Referenzen für anti-DKK2 Antikörper (ABIN357070) Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-DKK2 Antikörper (ABIN357070)

Produktdetails anti-DKK2 Antikörper Target Details DKK2 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003

Brott, Sokol: "Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins." in: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6100-10, 2002

Krupnik, Sharp, Jiang, Robison, Chickering, Amaravadi, Brown, Guyot, Mays, Leiby, Chang, Duong, Goodearl, Gearing, Sokol, McCarthy: "Functional and structural diversity of the human Dickkopf gene family." in: Gene, Vol. 238, Issue 2, pp. 301-13, 1999

Bilder

Produktdetails anti-DKK2 Antikörper Target Details DKK2 Anwendungsinformationen Handhabung Referenzen für anti-DKK2 Antikörper (ABIN357070) zurück nach oben
Bilder des Herstellers
 image for anti-Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) (C-Term) antibody (ABIN357070) anti-Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) (C-Term) antibody
 image for anti-Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) (C-Term) antibody (ABIN357070) anti-Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) (C-Term) antibody (Image 2)