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High serum levels of sclerostin (zeige SOST Proteine) and Dkk-1 are associated with acute ischaemic stroke
regulated by Dkk-1 secreted by Multiple Myeloma cells and is a potential mechanism contributing to the osteoblast dysfunction noted in Multiple Myeloma.
DKK1 c.121G>A (p.(A41T)) variant was identified in the family with Chiari malformation type 1. Screening of DKK1 in a cohort of 65 CMI sporadic patients identified another missense variant, the c.359G>T (p.(R120L)), in two unrelated patients.
LRP6 (zeige LRP6 Proteine) ectodomain becomes highly compact upon complexation with the Wnt (zeige WNT2 Proteine) antagonist Dkk1, suggesting a potential role for the ectodomain conformational change in the regulation of receptor oligomerization and signaling.
Our results suggest that measurement of DKK-1 combined with DKK-1 autoantibodies is a potentially valuable tool for the early detection of ESCC.
TET1 (zeige TET1 Proteine) potently inhibited canonical Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling by demethylating and upregulating two upstream antagonists of this pathway, SFRP2 (zeige SFRP2 Proteine) and DKK1, which was associated with inhibition of EMT (zeige ITK Proteine) and cancer cell metastasis.
This is the first study demonstrating a link between B cell depletion and skin Dkk-1 upregulation in patients with systemic sclerosis
We found significantly increased levels of DKK-1 in patients with acute CO poisoning, compared to healthy controls. High levels of serum DKK-1 in patients were significantly correlated with severe neurological symptoms.
DKK1 prevents lung metastasis of breast cancer cells but promotes breast-to-bone metastasis.
Structure of the dual-mode Wnt (zeige WNT2 Proteine) regulator Kremen1 (zeige KREMEN1 Proteine) and insight into ternary complex formation with LRP6 (zeige LRP6 Proteine) and DKK1 have been presented.
The decreased expression of Dkk-1 in somatic cell nuclear transfer cotyledons that are prone to abnormal placentation suggests a role in cotyledon formation but the mechanism and regulatory control is yet to be revealed[DICKKOPF-1]
Palmatin effect on osteoarthritis is likely mediated via the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and Hedgehog (zeige SHH Proteine) signaling
DKK1 inhibits the WNT (zeige WNT2 Proteine) signaling pathway and improves pig oocyte maturation.
Association analysis showed that different genotypes of DKK1 were associated with loin muscle area.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (zeige CHRD Proteine) and subsequent maintenance of dkk1b expression levels.
Kremen1 (zeige KREMEN1 Proteine) modulates Wnt (zeige WNT2 Proteine) activity by restricting the range of secreted Dkk proteins during collective cell migration in the posterior lateral line primordium
Neuromast size is controlled by a balance between growth-promoting Wnt (zeige WNT2 Proteine) signaling activity in proliferation-competent cells and Wnt (zeige WNT2 Proteine)-inhibiting Dkk activity produced by differentiated sensory cells.
Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles on the surfaces of adult male zebrafish pectoral fins
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (zeige WNT2 Proteine) signaling inhibitor, Dkk, and induced expression of the Wnt (zeige WNT2 Proteine) ligand, Wnt4a.
Membrane-bound DKK-1 is a novel Foxp3 (zeige FOXP3 Proteine) postive Treg cell derived mediator to maintain immunological tolerance in T-cell-mediated autoimmune colitis.
Dkk1 promotes hematopoietic regeneration via direct effects on hematopoietic stem cells, decreasing the levels of mitochondrial reactive oxygen species and suppressing senescence, and via indirect effects on bone marrow endothelial cells, inducing EGF (zeige EGF Proteine) secretion.
Recombinant Dkk1 suppresses beta-catenin (zeige CTNNB1 Proteine) target genes in myeloid-derived suppressor cells (MDSCs) from mice and humans and anti-Dkk1 loses its antitumor effects in mice lacking beta-catenin (zeige CTNNB1 Proteine) in myeloid cells or after depletion of MDSCs, demonstrating that Dkk1 directly targets MDSCs.
A negative feedback loop involving WNT6 (zeige WNT6 Proteine) and DKK1 attenuates canonical WNT6 (zeige WNT6 Proteine)-beta-catenin (zeige CTNNB1 Proteine) signaling, thereby allowing teratocarcinoma cells to differentiate.
Collectively, miR (zeige MLXIP Proteine)-9 promotes osteoblast differentiation of mesenchymal stem cells by suppressing DKK1 gene expression.
that Dkk1 negatively regulates BMP9 (zeige GDF2 Proteine)-induced osteogenic differentiation.
Disturbed oscillatory flow increases DKK1 expression. DKK1 knockdown attenuates OSS-induced monocyte adhesion and endothelial impairment. Genetic silencing of DKK1 limits atherogenesis in ApoE (zeige APOE Proteine)-/- mice.
Dickkopf1 receptor Kremen1 (zeige KREMEN1 Proteine) is a bona fide dependence receptor, triggering cell death unless bound to its ligand.
These results suggest that inhibiting Wnt (zeige WNT2 Proteine) signaling in embryonic stem cells using DKK1 may promote mouse ESCs (zeige NR2E3 Proteine) to differentiate into endoderm in vitro and in vivo
dkk1 preferentially induced the expression of POX2, suggesting that dkk1 works as a morphogen (zeige SHH Proteine) to determine the different lineages.
N1 is a novel signaling domain within the intact protein that is responsible for the potent effects of Dkk1 on the induction and patterning of the body axis and heart
target Wnts of Dkk activity are maternal Wnt5a (zeige WNT5A Proteine) and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
dickkopf 1 homolog
, dickkopf related protein-1
, dickkopf-1 like
, dickkopf-like protein 1
, dickkopf-related protein 1
, dickkopf homolog 1
, dickkopf 1
, dickkopf protein