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anti-Human CSNK1A1 Antikörper:
anti-Mouse (Murine) CSNK1A1 Antikörper:
anti-Rat (Rattus) CSNK1A1 Antikörper:
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Human Polyclonal CSNK1A1 Primary Antibody für IP, PLA - ABIN438716
Hutchinson, Shanware, Chang, Tibbetts: Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. in The Journal of biological chemistry 2011
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Human Polyclonal CSNK1A1 Primary Antibody für IHC (p), WB - ABIN391597
Rodriguez, Yang, Hasselblatt, Liu, Zhou, Rauh-Hain, Ng, Choi, Fong, Agar, Welch, Berkowitz, Ng: Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. in EMBO molecular medicine 2012
casein kinase 1 phosphorylates the SQSTM1 (zeige SQSTM1 Antikörper) S349 residue when harmful proteins accumulate under HSF1 (zeige HSF1 Antikörper) stress
Maintenance of the progenitors thus requires cooperation by PRMT1 (zeige PRMT1 Antikörper) and CSNK1a1 to sustain proliferation gene expression and suppress premature differentiation driven by GRHL3 (zeige GRHL3 Antikörper)
These data indicate that CK1alpha has a dominant and non-redundant function in melanoma cells
Disruption of CK1alpha function in myeloma cells resulted in decreased Mdm2 (zeige MDM2 Antikörper), increased p53 (zeige TP53 Antikörper) and p21 (zeige CDKN1A Antikörper) and reduced expression of beta-catenin (zeige CTNNB1 Antikörper) and AKT (zeige AKT1 Antikörper).
CK1delta enhances EPO (zeige EPO Antikörper) secretion from liver cancer cells under hypoxia by modifying HIF-2alpha (zeige EPAS1 Antikörper) and promoting its nuclear accumulation.
CKIalpha-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII (zeige CAMK2G Antikörper) gamma and delta may have negative roles in the HCV life cycle.
Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
study focuses on, how the structural dynamics and conformational changes of two CK1 (zeige CSNK1A1L Antikörper) isoforms are synchronized in carcinogenic pathway
NIFK (zeige MKI67IP Antikörper) is required for lung cancer progression via the RUNX1 (zeige RUNX1 Antikörper)-dependent CK1alpha repression, which activates TCF4 (zeige TCF4 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling in metastasis and the Ki-67 (zeige MKI67 Antikörper)-dependent regulation in cell proliferation.
The study describes the identification of a novel, tumor-specific missense mutation in the active site of casein kinase 1 alpha(CSNK1A1) using activity-based proteomics.
Phosphorylation of LRRK2 (zeige LRRK2 Antikörper) by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7 (zeige ARHGEF7 Antikörper).
Phosphorylation of FADD (zeige FADD Antikörper) by the kinase CK1alpha promotes KRASG12D-induced lung cancer.
Csnk1a1 knockdown results in decreased Rps6 (zeige RPS6 Antikörper) phosphorylation, increased p53 (zeige TP53 Antikörper) activity, and myeloid differentiation.
study for the first time demonstrates that CK1alpha is required for chromosome alignment and segregation during oocyte meiotic maturation and early embryo development
Silencing or deleting the p53 (zeige TP53 Antikörper) gene demonstrated that genotoxic stress elicited Wnt (zeige WNT2 Antikörper) signaling in a p53 (zeige TP53 Antikörper)-independent manner. Instead, this response occurred through reduced abundance of Csnk1a1 (CK1alpha), a kinase that inhibits beta-catenin (zeige CTNNB1 Antikörper).
maintenance of intestinal homeostasis in CKIalpha-deficient gut (zeige GUSB Antikörper) requires p53 (zeige TP53 Antikörper)-mediated growth control, because the combined ablation of Csnk1a1 and either p53 (zeige TP53 Antikörper) or its target gene p21 (zeige D4S234E Antikörper) triggered high-grade dysplasia with extensive proliferation
Casein kinase I (zeige CSNK1D Antikörper) and casein kinase II (zeige CSNK2A1 Antikörper) differentially regulate axin (zeige AXIN1 Antikörper) function
CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C
CK1 regulates fast synaptic transmission by glutamate (zeige GRIN1 Antikörper) in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 (zeige PPP1CB Antikörper) &/or 2A & increased dephosphorylation of NMDA receptors.
Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-beta and casein kinase-1alpha and consequently degraded by the proteasome.
The phosphorylation of p53 (zeige TP53 Antikörper) by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.
data provide a molecular insight into the structural features that underlie the site specificity of CK1a
we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes.
Expected genes in the Scar-Arp2 (zeige ACTR2 Antikörper)/3 actin (zeige ACTB Antikörper) nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature.
CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser (zeige SIGLEC1 Antikörper) and Thr (zeige TRH Antikörper) residues in the N-terminus and targeting it for degradation.
2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways
expression of doubletime in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm
doubletime and CKII (zeige CSNK2A1 Antikörper) kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway.
Mutation of ck1alpha or -epsilon or sgg/gsk3beta (zeige GSK3b Antikörper) in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis.
, casein kinase I isoform alpha
, clock regulator kinase
, down-regulated in lung cancer
, casein kinase I-alpha
, casein kinase I alpha LS
, protein kinase CK1 (casein kinase 1) isoform alpha
, casein kinase 1 alpha
, caesin kinase I alpha
, casein kinase 1
, casein kinase 1a
, casein kinase 1alpha
, casein kinase I
, casein kinase ialpha