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anti-Human CSNK1A1 Antikörper:
anti-Mouse (Murine) CSNK1A1 Antikörper:
anti-Rat (Rattus) CSNK1A1 Antikörper:
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Human Polyclonal CSNK1A1 Primary Antibody für IP, PLA - ABIN438716
Hutchinson, Shanware, Chang, Tibbetts: Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. in The Journal of biological chemistry 2011
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Human Polyclonal CSNK1A1 Primary Antibody für IHC (p), WB - ABIN391597
Rodriguez, Yang, Hasselblatt, Liu, Zhou, Rauh-Hain, Ng, Choi, Fong, Agar, Welch, Berkowitz, Ng: Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. in EMBO molecular medicine 2012
we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes.
Expected genes in the Scar-Arp2 (zeige ACTR2 Antikörper)/3 actin (zeige ACTB Antikörper) nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature.
CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser (zeige SIGLEC1 Antikörper) and Thr (zeige TRH Antikörper) residues in the N-terminus and targeting it for degradation.
2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways
expression of doubletime in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm
doubletime and CKII (zeige CSNK2A1 Antikörper) kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway.
Mutation of ck1alpha or -epsilon or sgg/gsk3beta (zeige GSK3b Antikörper) in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo.
These data indicate that CK1alpha has a dominant and non-redundant function in melanoma cells
KRT1 and the specific polymorphism of KRT1 in this Chinese Han population are associated with autoimmune diseases SLE and SSc (zeige CYP11A1 Antikörper)
Disruption of CK1alpha function in myeloma cells resulted in decreased Mdm2 (zeige MDM2 Antikörper), increased p53 (zeige TP53 Antikörper) and p21 (zeige CDKN1A Antikörper) and reduced expression of beta-catenin (zeige CTNNB1 Antikörper) and AKT (zeige AKT1 Antikörper).
CK1delta enhances EPO (zeige EPO Antikörper) secretion from liver cancer cells under hypoxia by modifying HIF-2alpha (zeige EPAS1 Antikörper) and promoting its nuclear accumulation.
CKIalpha-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII (zeige CAMK2G Antikörper) gamma and delta may have negative roles in the HCV life cycle.
Case Report: post-zygotic mosaicism of KRT/1o mutations in epidermolytic Ichthyosis (zeige LBR Antikörper).
KRT1 played an important role of maintaining epithelial barrier and its down-regulation in intestinal tissue was correlated with the progression of inflammatory bowel disease.
Report genetic/clinical spectrum of KRT1 mutations in keratinopathic ichthyosis (zeige LBR Antikörper).
Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
demonstrated the presence of a genetic cutaneous mosaicism. Both patients carry the KRT1 pI479T substitution, but in the palmoplantar areas of one of them, only the mutated allele is expressed (hemizygous). This leads to highlight a new type of cutaneous mosaic, the palmoplantar mosaicism
Phosphorylation of LRRK2 (zeige LRRK2 Antikörper) by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7 (zeige ARHGEF7 Antikörper).
Phosphorylation of FADD (zeige FADD Antikörper) by the kinase CK1alpha promotes KRASG12D-induced lung cancer.
Csnk1a1 knockdown results in decreased Rps6 (zeige RPS6 Antikörper) phosphorylation, increased p53 (zeige TP53 Antikörper) activity, and myeloid differentiation.
study for the first time demonstrates that CK1alpha is required for chromosome alignment and segregation during oocyte meiotic maturation and early embryo development
Silencing or deleting the p53 (zeige TP53 Antikörper) gene demonstrated that genotoxic stress elicited Wnt (zeige WNT2 Antikörper) signaling in a p53 (zeige TP53 Antikörper)-independent manner. Instead, this response occurred through reduced abundance of Csnk1a1 (CK1alpha), a kinase that inhibits beta-catenin (zeige CTNNB1 Antikörper).
maintenance of intestinal homeostasis in CKIalpha-deficient gut (zeige GUSB Antikörper) requires p53 (zeige TP53 Antikörper)-mediated growth control, because the combined ablation of Csnk1a1 and either p53 (zeige TP53 Antikörper) or its target gene p21 (zeige D4S234E Antikörper) triggered high-grade dysplasia with extensive proliferation
Casein kinase I (zeige CSNK1D Antikörper) and casein kinase II (zeige CSNK2A1 Antikörper) differentially regulate axin (zeige AXIN1 Antikörper) function
CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C
CK1 regulates fast synaptic transmission by glutamate (zeige GRIN1 Antikörper) in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 (zeige PPP1CB Antikörper) &/or 2A & increased dephosphorylation of NMDA receptors.
Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-beta and casein kinase-1alpha and consequently degraded by the proteasome.
The phosphorylation of p53 (zeige TP53 Antikörper) by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.
data provide a molecular insight into the structural features that underlie the site specificity of CK1a
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
, caesin kinase I alpha
, casein kinase 1
, casein kinase 1a
, casein kinase 1alpha
, casein kinase I
, casein kinase ialpha
, casein kinase I isoform alpha
, clock regulator kinase
, down-regulated in lung cancer
, casein kinase I-alpha
, casein kinase I alpha LS
, CK II alpha
, casein kinase 2, alpha subunit
, casein kinase II subunit alpha
, casein kinase 1 alpha
, protein kinase CK1 (casein kinase 1) isoform alpha
, 67 kDa cytokeratin
, cytokeratin 1
, epidermolytic hyperkeratosis 1
, hair alpha protein
, keratin, type II cytoskeletal 1
, type-II keratin Kb1
, epithelial keratin 1
, epithelial keratin-1
, keratin 1 (epidermolytic hyperkeratosis)