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Results suggest that amino enhancer of split protein (AES) plays an important role in controlling tumor growth and metastasis of prostate cancer (PCa (zeige FLVCR1 ELISA Kits)) by regulating both androgen receptor (AR (zeige AR ELISA Kits)) and Notch (zeige NOTCH1 ELISA Kits) signaling pathway.
results indicate that Aes may belong to a novel family of metastasis su (zeige YY2 ELISA Kits)ppressors with a CpG-island promoter enhancer, and it is regulated transcriptionally
heat shock cognate 70 (HSC70 (zeige HSPA8 ELISA Kits)) is an essential component of Aes foci in colorectal cancer cells.
AES is a transcriptional repressor for HNF-1-alpha (zeige HNF1A ELISA Kits) in pancreatic beta-cell.
AES binds to PROP1 (zeige PROP1 ELISA Kits) and represses its expression; PROP1 (zeige PROP1 ELISA Kits) mutation is a likely cause of combined pituitary hormone (zeige CGA ELISA Kits) deficiency.
GRG5/AES interacts with TCF4 (zeige TCF4 ELISA Kits) and represses Wnt (zeige WNT2 ELISA Kits)-mediated transcription both in human cells and zebrafish embryos.
alteration of the malignant behavior of cancer cells by AES is related to RND3 (zeige RND3 ELISA Kits) regulation.
In the presence of NUP98 (zeige NUP98 ELISA Kits)-HOXA9 (zeige HOXA9 ELISA Kits), AES caused an increase in long-term proliferation of primary human CD34 (zeige CD34 ELISA Kits)+ cells with a marked increase in the numbers of primitive cells.
Elevated levels of AES mRNA (zeige RUNX1 ELISA Kits)and (zeige RUNX1T1 ELISA Kits)protein were confirmed in AML1/ETO-expressing leukemia cells, as well as in other acute myeloid leukemia specimens.
LRP6 (zeige LRP6 ELISA Kits)-ICD (zeige GNPTAB ELISA Kits) interacts with AES exclusively in the nucleus and represses AES mediated TCF (zeige HNF4A ELISA Kits)/LEF-1 (zeige LEF1 ELISA Kits) reporter transcription.
in a transplantation mouse model of liver metastases, expression of Yy2 (zeige YY2 ELISA Kits) (and therefore of Aes) is downregulated
The finding that Foxh1 (zeige FOXH1 ELISA Kits)-Grg-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg interactions.
Self-renewal induced by AML1 (zeige RUNX1 ELISA Kits)/ETO (zeige RUNX1T1 ELISA Kits) in primary murine progenitors was inhibited when Aes was decreased or absent.
The Aes gene functions as an endogenous metastasis suppressor. Aes inhibits Notch (zeige NOTCH1 ELISA Kits) signaling by converting active Rbpj (zeige RBPJ ELISA Kits) transcription complexes into repression complexes on insoluble nuclear matrix.
Data suggest that Grg5 modulates the activities of transcription factors in vivo to affect Ihh (zeige IHH ELISA Kits) expression and the function of long bone growth plates.
Tcf4 (zeige TCF4 ELISA Kits) and Aes influence pituitary growth and development, and place Tcf4 (zeige TCF4 ELISA Kits) and Tle3 in the genetic hierarchy with Prop1 (zeige PROP1 ELISA Kits)
Grg5 acts as a positive regulator of Runx2 (zeige RUNX2 ELISA Kits) activity and is necessary for full expression and signalling of Indian hedgehog (Ihh (zeige IHH ELISA Kits)).
Data show that GRG proteins, including GRG5, interact with two regulators of GnRH transcription, the homeodomain proteins MSX1 and OCT1, and regulate GnRH promoter activity.
direct interaction between Otx2 and Grg co-repressors regulates GnRH gene expression in hypothalamic neurons
GRG5/AES interacts with TCF4 (zeige TCF7L2 ELISA Kits) and represses Wnt (zeige WNT2 ELISA Kits)-mediated transcription both in human cells and zebrafish embryos.
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.
gp130-associated protein GAM
, related to Drosophila groucho
, amino enhancer of split
, amino enhancer split
, amino-terminal enhancer of split
, transducin-like enhancer of split 4 homolog of Drosophila E(spl)