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WNT Signalweg

Wnts are a class of evolutionarily-conserved, lipid-modified glycoproteins that play a pivotal role in development and homeostasis through a number of different paracrine and autocrine signal-transduction pathways. During early development, Wnt signaling plays a major role in axon guidance, cell polarity, and body axis specification.

Extracellular Wnts bind a variety of different receptors, and initiate signaling in several distinct pathways. Receptors include seven-pass transmembrane Frizzleds and receptor tyrosine kinases ROR and Ryk.

Wnt signaling pathways can result in changes to gene transcription. For example, in the canonical β-catenin signaling pathway Wnt signaling prevents destruction of the transcriptional regulator β-catenin. Wnt signaling can also prompt morphological changes to cellular structure e.g., the non-canonical planar cell polarity pathway induces a kinase cascade that results in reorganization of actin, a core component of the cytoskeleton.

Antagonists

DKK1 (Dickkopf Homolog 1 (Xenopus Laevis)):

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010].   More...
Antigene in dieser Kategorie:
DKK4 (Dickkopf Homolog 4 (Xenopus Laevis)): DKK4 Antikörper DKK4 ELISA Kits DKK4 Proteine
KREMEN1 (Kringle Containing Transmembrane Protein 1): KREMEN1 Antikörper KREMEN1 ELISA Kits KREMEN1 Proteine
KREMEN2 (Kringle Containing Transmembrane Protein 2): KREMEN2 Antikörper KREMEN2 ELISA Kits KREMEN2 Proteine
DKK2 (Dickkopf 2 Homolog (Xenopus Laevis)): DKK2 Antikörper DKK2 ELISA Kits DKK2 Proteine
FRZB (Frizzled-Related Protein): FRZB Antikörper FRZB ELISA Kits FRZB Proteine
IGFBP4 (Insulin-Like Growth Factor Binding Protein 4): IGFBP4 Antikörper IGFBP4 ELISA Kits IGFBP4 Proteine
IGFBP5 (Insulin-Like Growth Factor Binding Protein 5): IGFBP5 Antikörper IGFBP5 ELISA Kits IGFBP5 Proteine
IGFBP6 (Insulin-Like Growth Factor Binding Protein 6): IGFBP6 Antikörper IGFBP6 ELISA Kits IGFBP6 Proteine
SFRP1 (Secreted Frizzled-Related Protein 1): SFRP1 Antikörper SFRP1 ELISA Kits SFRP1 Proteine
SFRP2 (Secreted Frizzled-Related Protein 2): SFRP2 Antikörper SFRP2 ELISA Kits SFRP2 Proteine
SFRP4 (Secreted Frizzled-Related Protein 4): SFRP4 Antikörper SFRP4 ELISA Kits SFRP4 Proteine
SFRP5 (Secreted Frizzled-Related Protein 5): SFRP5 Antikörper SFRP5 ELISA Kits SFRP5 Proteine
WIF1 (WNT Inhibitory Factor 1): WIF1 Antikörper WIF1 ELISA Kits WIF1 Proteine
ZNRF3 (Zinc and Ring Finger Protein 3): ZNRF3 Antikörper   ZNRF3 Proteine

beta-Catenin Pathway

APC - Adenomatous Polyposis Coli

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated...   More...

CSNK1A1 (Casein Kinase 1, alpha 1):

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member...   More...

TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box)):

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell...   More...

TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box)):

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq,...   More...
Antigene in dieser Kategorie:
AES (Amino-terminal Enhancer of Split): AES Antikörper AES ELISA Kits AES Proteine
AXIN1 (Axin 1): AXIN1 Antikörper AXIN1 ELISA Kits AXIN1 Proteine
CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa): CTNNB1 Antikörper CTNNB1 ELISA Kits CTNNB1 Proteine
DVL1 (Dishevelled, Dsh Homolog 1 (Drosophila)): DVL1 Antikörper DVL1 ELISA Kits DVL1 Proteine
GSK3a - GSK3 alpha: GSK3a Antikörper GSK3a ELISA Kits GSK3a Proteine
GSK3b - GSK3 beta: GSK3b Antikörper    
LLGL1 (Lethal Giant Larvae Homolog 1 (Drosophila)): LLGL1 Antikörper LLGL1 ELISA Kits LLGL1 Proteine
LLGL2 (Lethal Giant Larvae Homolog 2 (Drosophila)): LLGL2 Antikörper LLGL2 ELISA Kits LLGL2 Proteine
LEF1 (Lymphoid Enhancer-Binding Factor 1): LEF1 Antikörper LEF1 ELISA Kits LEF1 Proteine
PYGO1 (Pygopus Homolog 1 (Drosophila)): PYGO1 Antikörper   PYGO1 Proteine
PYGO2 (Pygopus Homolog 2 (Drosophila)): PYGO2 Antikörper   PYGO2 Proteine
TCF3 (Transcription Factor 3): TCF3 Antikörper    
TCF4 (Transcription Factor 4): TCF4 Antikörper TCF4 ELISA Kits TCF4 Proteine
TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box)): TCF7 Antikörper TCF7 ELISA Kits TCF7 Proteine
TLE1 (Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila)): TLE1 Antikörper   TLE1 Proteine
TLE2 (Transducin-Like Enhancer of Split 2 (E(sp1) Homolog, Drosophila)): TLE2 Antikörper TLE2 ELISA Kits TLE2 Proteine
TLE4 (Transducin-Like Enhancer of Split 4 (E(sp1) Homolog, Drosophila)): TLE4 Antikörper    
TLE6 (Transducin-Like Enhancer of Split 6 (E(sp1) Homolog, Drosophila)): TLE6 Antikörper   TLE6 Proteine

Calcium Pathway

CAMK2B (Calcium/calmodulin-Dependent Protein Kinase (CaM Kinase) II beta):

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that...   More...

CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha):

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is...   More...

CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa)):

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to...   More...

PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isozyme):

catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation [RGD, Feb 2006].   More...
Antigene in dieser Kategorie:
CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta): CAMK2D Antikörper CAMK2D ELISA Kits CAMK2D Proteine
CAMK2G (Calcium/calmodulin-Dependent Protein Kinase II gamma): CAMK2G Antikörper CAMK2G ELISA Kits CAMK2G Proteine
CALM1 - Calmodulin 1 (Phosphorylase Kinase, Delta): CALM1 Antikörper CALM1 ELISA Kits CALM1 Proteine
PLCb2 - Phospholipase C beta 2: PLCb2 Antikörper PLCb2 ELISA Kits PLCb2 Proteine
PLCb4 - Phospholipase C beta 4: PLCb4 Antikörper PLCb4 ELISA Kits  
PLCd3 - Phospholipase C delta 3: PLCd3 Antikörper PLCd3 ELISA Kits PLCd3 Proteine
PLCG2 - Phospholipase C gamma 2: PLCG2 Antikörper PLCG2 ELISA Kits PLCG2 Proteine
PLCB1 - Phospholipase C beta 1: PLCB1 Antikörper PLCB1 ELISA Kits PLCB1 Proteine
PLCB3 (phospholipase C, beta 3 (Phosphatidylinositol-Specific)): PLCB3 Antikörper PLCB3 ELISA Kits  
PLCD1 (phospholipase C, delta 1): PLCD1 Antikörper PLCD1 ELISA Kits PLCD1 Proteine
PLCG1 - Phospholipase C gamma 1: PLCG1 Antikörper PLCG1 ELISA Kits PLCG1 Proteine
PKCa - PKC alpha: PKCa Antikörper PKCa ELISA Kits PKCa Proteine
PRKCB - PKC beta: PRKCB Antikörper PRKCB ELISA Kits PRKCB Proteine
PRKCG - PKC gamma: PRKCG Antikörper PRKCG ELISA Kits PRKCG Proteine
PPP3CB (Protein Phosphatase 3, Catalytic Subunit, beta Isozyme): PPP3CB Antikörper PPP3CB ELISA Kits PPP3CB Proteine
PPP3CC (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme): PPP3CC Antikörper PPP3CC ELISA Kits PPP3CC Proteine
PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha): PPP3R1 Antikörper PPP3R1 ELISA Kits PPP3R1 Proteine

Co-Receptors

LRP5 (Low Density Lipoprotein Receptor-Related Protein 5):

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role...   More...

LRP6 (Low Density Lipoprotein Receptor-Related Protein 6):

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through...   More...

Frizzleds

Fzd1 - FZD1

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if...   More...

FZD2 (Frizzled Family Receptor 2):

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and...   More...
Antigene in dieser Kategorie:
LOC100313610 - Frizzled 5/8 Protein Receptor: LOC100313610 Antikörper    
FZD10 (Frizzled Family Receptor 10): FZD10 Antikörper FZD10 ELISA Kits FZD10 Proteine
FZD3 (Frizzled Family Receptor 3): FZD3 Antikörper FZD3 ELISA Kits FZD3 Proteine
FZD4 (Frizzled Family Receptor 4): FZD4 Antikörper FZD4 ELISA Kits FZD4 Proteine
FZD6 (Frizzled Family Receptor 6): FZD6 Antikörper FZD6 ELISA Kits FZD6 Proteine
FZD7 (Frizzled Family Receptor 7): FZD7 Antikörper    
FZD8 (Frizzled Family Receptor 8): FZD8 Antikörper FZD8 ELISA Kits FZD8 Proteine
GPBAR1 (G Protein-Coupled Bile Acid Receptor 1): GPBAR1 Antikörper GPBAR1 ELISA Kits GPBAR1 Proteine

PCP Pathway

DAAM1 (Dishevelled Associated Activator of Morphogenesis 1):

Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture,...   More...

JUN - C-JUN

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul...   More...

RHO - Rhodopsin

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein...   More...
Antigene in dieser Kategorie:
MAPK10 (Mitogen-Activated Protein Kinase 10): MAPK10 Antikörper MAPK10 ELISA Kits MAPK10 Proteine
MAPK8 - JNK: MAPK8 Antikörper MAPK8 ELISA Kits MAPK8 Proteine
MAPK9 (Mitogen-Activated Protein Kinase 9): MAPK9 Antikörper MAPK9 ELISA Kits MAPK9 Proteine
NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive): NFAT5 Antikörper NFAT5 ELISA Kits NFAT5 Proteine
NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1): NFATC1 Antikörper NFATC1 ELISA Kits NFATC1 Proteine
NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2): NFAT1 Antikörper NFAT1 ELISA Kits NFAT1 Proteine
NFATC3 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3): NFATC3 Antikörper NFATC3 ELISA Kits NFATC3 Proteine
NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4): NFATC4 Antikörper NFATC4 ELISA Kits NFATC4 Proteine
RHOA (Ras Homolog Gene Family, Member A): RHOA Antikörper RHOA ELISA Kits RHOA Proteine
RHOC (Ras Homolog Gene Family, Member C): RHOC Antikörper RHOC ELISA Kits RHOC Proteine
RHO (rho): RHO Antikörper RHO ELISA Kits  
ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1): ROCK1 Antikörper ROCK1 ELISA Kits ROCK1 Proteine
ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2): ROCK2 Antikörper ROCK2 ELISA Kits ROCK2 Proteine

Receptor Tyrosine Kinases

ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1):

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed...   More...

ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2):

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by...   More...

RYK (RYK Receptor-Like Tyrosine Kinase):

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that...   More...

WNTs

WNT2 (Wingless-Type MMTV Integration Site Family Member 2):

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided...   More...

WNT1 (Wingless-Type MMTV Integration Site Family, Member 1):

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be...   More...
Antigene in dieser Kategorie:
WNT3A (Wingless-Related MMTV Integration Site 3A): WNT3A Antikörper   WNT3A Proteine
WNT10A (Wingless-Type MMTV Integration Site Family, Member 10A): WNT10A Antikörper WNT10A ELISA Kits WNT10A Proteine
WNT10B (Wingless-Type MMTV Integration Site Family, Member 10B): WNT10B Antikörper WNT10B ELISA Kits WNT10B Proteine
WNT16 (Wingless-Type MMTV Integration Site Family, Member 16): WNT16 Antikörper WNT16 ELISA Kits WNT16 Proteine
WNT2B (Wingless-Type MMTV Integration Site Family, Member 2B): WNT2B Antikörper WNT2B ELISA Kits WNT2B Proteine
WNT3 (Wingless-Type MMTV Integration Site Family, Member 3): WNT3 Antikörper WNT3 ELISA Kits WNT3 Proteine
WNT3A (Wingless-Type MMTV Integration Site Family, Member 3A): WNT3A Antikörper WNT3A ELISA Kits WNT3A Proteine
WNT4 (Wingless-Type MMTV Integration Site Family, Member 4): WNT4 Antikörper WNT4 ELISA Kits WNT4 Proteine
WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A): WNT5A Antikörper WNT5A ELISA Kits WNT5A Proteine
WNT6 (Wingless-Type MMTV Integration Site Family, Member 6): WNT6 Antikörper WNT6 ELISA Kits WNT6 Proteine
WNT7A (Wingless-Type MMTV Integration Site Family, Member 7A): WNT7A Antikörper WNT7A ELISA Kits WNT7A Proteine
WNT7B (Wingless-Type MMTV Integration Site Family, Member 7B): WNT7B Antikörper WNT7B ELISA Kits WNT7B Proteine
WNT8A (Wingless-Type MMTV Integration Site Family, Member 8A): WNT8A Antikörper WNT8A ELISA Kits WNT8A Proteine
WNT8B (Wingless-Type MMTV Integration Site Family, Member 8B): WNT8B Antikörper    
WNT9A (Wingless-Type MMTV Integration Site Family, Member 9A): WNT9A Antikörper WNT9A ELISA Kits WNT9A Proteine
WNT9B (Wingless-Type MMTV Integration Site Family, Member 9B): WNT9B Antikörper WNT9B ELISA Kits WNT9B Proteine