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WT1 interference with Wnt (zeige WNT2 Proteine) signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.
This study demonstrated that WT1 is a good marker for monitoring the response to therapy in patients affected by myelofibrosis.
major repressor of the CMIP (zeige CMIP Proteine) gene in physiological situations
Study results show the role of WT1 in regulating decidualization in human endometrial stromal cells. C/EBPbeta (zeige CEBPB Proteine) is an upstream gene that regulates WT1 expression by binding to the novel enhancer region.
MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1.
Study reveals a novel role for Wt1 in early mammalian development and identifies proteases as critical mediators of the maternal-embryonic interaction. Data also suggest that the role of Wt1 in regulating fertility is conserved in mammals.
WT1 acts as a tumour promoter in osteosarcoma and it could be a potential therapeutic target.
a novel role of WT1 mutations in the deregulation of epigenetic programs in leukemic cells through its interaction with TET proteins (Review)
Mutations of WT1 gene is associated with Acute myeloid leukemia (zeige BCL11A Proteine).
The findings of the present study indicate that all females with SRNS-FSGS (zeige ACTN4 Proteine) should be screened for WT1 gene mutation to diagnose whether they have FS for possible gonadectomy.
Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences in DNA binding and altered responses to epigenetic cytosine modifications.
Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.
Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.
WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts
WT1 is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 (zeige SF1 Proteine) expression. Without Wt1, the expression of Sf1 (zeige SF1 Proteine) was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells.
study provides novel insights into the role of WT1 and GATA4 (zeige GATA4 Proteine) during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development
WT1 regulates reporter gene expression through interaction with 3' UTR-binding sites
These results indicate that Osr1 (zeige OSR1 Proteine) and Wt1 act synergistically to regulate nephron endowment by controlling metanephric mesenchyme specification during early nephrogenesis.
Wt1 regulates the development of FLC.
WT1 stimulates IGFBP5 (zeige IGFBP5 Proteine) transcription in developing murine kidney.
Over expression of miR (zeige MLXIP Proteine)-206 promotes podocyte injury via downregulation of WT1, which provides a new pathogenic mechanism for Focal segmental glomerulosclerosis and miR (zeige MLXIP Proteine)-206 may be a potential therapeutic target.
by targeting WT1, miR743a suppresses the proliferation of MM cells in vitro, and probably possesses vital functions in kidney development and kidneyassociated diseases.
To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors
While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Wilms tumor protein
, amino-terminal domain of EWS
, last three zinc fingers of the DNA-binding domain of WT1
, Chick Wilm's tumour protein
, Wilms tumor 1
, Wilms tumor protein homolog A
, Wilms tumor protein homolog
, Wilms tumor suppressor protein 1b
, Wilm's tumor suppressor
, Wilms tumor protein homolog B