WT1 Proteine (WT1)

Bezeichnung:
Wilms Tumor 1 Proteine (WT1)
Auf www.antikoerper-online.de finden Sie aktuell 19 Wilms Tumor 1 (WT1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen WT1 Antikörper (295) und WT1 Kits (16) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 339 WT1 Produkte verfügbar.
Synonyme:
AWT1, CWT1, D630046I19Rik, EWS-WT1, GUD, NPHS4, si:ch211-160j6.3, WAGR, WIT-2, WT, Wt-1, wt1, WT33, XeWT1, xwt1, XWT1a, XWT1b, zgc:152697
alle Proteine anzeigen Gen GeneID UniProt
WT1 7490 P19544
WT1 24883 P49952
Maus WT1 WT1 22431  

Weitere Synonyme anzeigen

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Weitere Proteine zu WT1 Interaktionspartnern

Xenopus laevis Wilms Tumor 1 (WT1) Interaktionspartner

  1. WT1 interference with Wnt (zeige WNT2 Proteine) signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.

Human Wilms Tumor 1 (WT1) Interaktionspartner

  1. a novel role of WT1 mutations in the deregulation of epigenetic programs in leukemic cells through its interaction with TET proteins (Review)

  2. Mutations of WT1 gene is associated with Acute myeloid leukemia (zeige BCL11A Proteine).

  3. The findings of the present study indicate that all females with SRNS-FSGS (zeige ACTN4 Proteine) should be screened for WT1 gene mutation to diagnose whether they have FS for possible gonadectomy.

  4. Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences in DNA binding and altered responses to epigenetic cytosine modifications.

  5. Sequence variants in NPHS4 were identified in families with CRB2 (zeige CRB2 Proteine)-related syndrome.

  6. WT1 modulates Akt (zeige AKT1 Proteine)/JNK (zeige MAPK8 Proteine) signaling pathway mediated autophagy by controlling the expression of growth arrest-specific 1 (Gas1 (zeige GAS1 Proteine)).

  7. WT1 knock-down gave a corresponding decrease in QPRT (zeige QPRT Proteine) gene and protein expression. Chromatin-immunoprecipitation revealed WT1 binding to a conserved site in the first intron of the QPRT (zeige QPRT Proteine) gene.

  8. WT1 helps to differentiate Wilms' tumour from other paediatric renal tumours. It may help in differentiating the two subgroups of Wilms' tumour which have distinct molecular pathogenesis and biological behaviour, however, further prospective studies are required for validation of this hypothesis.

  9. a high WT1 mutation rate was observed in this group of steroid-resistant nephrotic syndrome patients

  10. Predictive value of pretransplantation molecular minimal residual disease assessment by WT1 gene expression in FLT3 (zeige FLT3 Proteine)-positive acute myeloid leukemia (zeige BCL11A Proteine).

Pig (Porcine) Wilms Tumor 1 (WT1) Interaktionspartner

  1. Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.

  2. Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.

  3. WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts

Mouse (Murine) Wilms Tumor 1 (WT1) Interaktionspartner

  1. study provides novel insights into the role of WT1 and GATA4 (zeige GATA4 Proteine) during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development

  2. WT1 regulates reporter gene expression through interaction with 3' UTR-binding sites

  3. These results indicate that Osr1 (zeige OSR1 Proteine) and Wt1 act synergistically to regulate nephron endowment by controlling metanephric mesenchyme specification during early nephrogenesis.

  4. Wt1 regulates the development of FLC.

  5. WT1 stimulates IGFBP5 (zeige IGFBP5 Proteine) transcription in developing murine kidney.

  6. Over expression of miR (zeige MLXIP Proteine)-206 promotes podocyte injury via downregulation of WT1, which provides a new pathogenic mechanism for Focal segmental glomerulosclerosis and miR (zeige MLXIP Proteine)-206 may be a potential therapeutic target.

  7. by targeting WT1, miR743a suppresses the proliferation of MM cells in vitro, and probably possesses vital functions in kidney development and kidneyassociated diseases.

  8. To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors

  9. miR (zeige MLXIP Proteine)-125a is a regulatory molecule that suppresses WT1 expression via a direct interaction with the 3'UTR of WT1 mRNA and miR (zeige MLXIP Proteine)-125a knockout mice induce myeloproliferative disease (MPD (zeige MVD Proteine)) and urogenital abnormalities

  10. The analysis presented here demonstrates that WT1 regulates a broad set of genes, and almost 50% of the top 200 podocyte-specific genes-as defined in the GUDMAP gene expression atlas-were bound by WT1.

Zebrafish Wilms Tumor 1 (WT1) Interaktionspartner

  1. While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.

WT1 Protein Überblick

Protein Überblick

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Alternative names and synonyms associated with WT1

  • Wilms tumor 1 (WT1)
  • Wilms tumor 1 (wt1-a)
  • Wilms tumor 1 (wt1)
  • Wilms tumor 1 (LOC100346776)
  • Wilms tumor protein (wt1)
  • Wilms tumor 1 (wt1-b)
  • Wilms tumor 1 (Wt1)
  • Wilms tumor 1 homolog (Wt1)
  • wilms tumor 1b (wt1b)
  • AWT1 Protein
  • CWT1 Protein
  • D630046I19Rik Protein
  • EWS-WT1 Protein
  • GUD Protein
  • NPHS4 Protein
  • si:ch211-160j6.3 Protein
  • WAGR Protein
  • WIT-2 Protein
  • WT Protein
  • Wt-1 Protein
  • wt1 Protein
  • WT33 Protein
  • XeWT1 Protein
  • xwt1 Protein
  • XWT1a Protein
  • XWT1b Protein
  • zgc:152697 Protein

Bezeichner auf Proteinebene für Wilms Tumor 1 Proteine (WT1)

Wilms tumor 1 , Wilms tumor protein homolog A , Wilms tumor protein homolog , Wilms tumor protein , amino-terminal domain of EWS , last three zinc fingers of the DNA-binding domain of WT1 , Wilm's tumor suppressor , Wilms tumor protein homolog B , Chick Wilm's tumour protein , Wilms tumor suppressor protein 1b

GENE ID SPEZIES
782183 Bos taurus
280959 Bos taurus
373588 Xenopus laevis
614584 Bos taurus
696061 Macaca mulatta
737987 Pan troglodytes
100101227 Ovis aries
100216184 Xenopus (Silurana) tropicalis
100346776 Oryctolagus cuniculus
100380493 Salmo salar
7490 Homo sapiens
378664 Xenopus laevis
396139 Gallus gallus
609253 Canis lupus familiaris
397338 Sus scrofa
24883 Rattus norvegicus
22431 Mus musculus
568416 Danio rerio
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