SCL/TAL1 Interrupting Locus ELISA Kits (STIL)
Auf finden Sie aktuell 0 SCL/TAL1 Interrupting Locus (STIL) ELISA Kits von unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen STIL Antikörper (20) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 23 STIL Produkte verfügbar.
chunp6907, MCPH7, SIL, sill, zgc:110502
list all ELISA KIts Gen GeneID UniProt
Ratte STIL STIL 313506  
Human STIL STIL 6491 Q15468
Maus STIL STIL 20460 Q60988

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Weitere ELISA Kits für STIL Interaktionspartner

Human SCL/TAL1 Interrupting Locus (STIL) Interaktionspartner

  1. Deletions of Stil is associated with acute T-lymphoblastic leukemia.

  2. Studies indicate that depletion of any one of the protein kinase (zeige CDK7 ELISA Kits) polo-like kinase 4 (PLK4 (zeige PLK4 ELISA Kits)) and the two proteins STIL and SAS-6 (zeige SASS6 ELISA Kits) blocks centriole duplication, and, conversely, overexpression causes centriole amplification.

  3. Reconstituting mouse embryonic fibroblasts lacking endogenous Stil, the authors show that STIL oligomerization mediated by these residues is not only important for the centrosomal functions of STIL during the canonical duplication process but also for de-novo formation of centrosomes.

  4. Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 (zeige TLX3 ELISA Kits) and SIL (zeige PMEL ELISA Kits)/TAL (zeige TALDO1 ELISA Kits) but a higher incidence of NKX2-5 (zeige NKX2-5 ELISA Kits) expression than recorded in Western countries

  5. data provide evidence for novel functions of the human oncogene (zeige RAB1A ELISA Kits) Stil in neural toxic susceptibility.

  6. The authors suggest that the STIL-coiled-coil region/PLK4 (zeige PLK4 ELISA Kits) interaction mediates PLK4 (zeige PLK4 ELISA Kits) activation as well as stabilization of centriolar PLK4 (zeige PLK4 ELISA Kits) and plays a key role in centriole duplication.

  7. The STIL p.Gly717Glu mutation was not able to fully restore the centriole duplication failure following depletion of endogenous STIL protein indicating the deleterious role of the mutation.

  8. Negative feedback by centriolar STIL regulates bimodal centriolar distribution of Plk4 (zeige PLK4 ELISA Kits) and seemingly restricts occurrence of procentriole formation to one site on each parental centriole.

  9. studies provide the first structural insight into how the malfunction of centriole proteins results in human disease and also reveal that the CPAP (zeige CENPJ ELISA Kits)-STIL interaction constitutes a conserved key step in centriole biogenesis

  10. STIL mutation causes autosomal recessive microcephalic lobar holoprosencephaly.

Mouse (Murine) SCL/TAL1 Interrupting Locus (STIL) Interaktionspartner

  1. STIL(-/-) mouse embryos do not contain centrioles or primary cilia, suggesting that these organelles are not essential for mammalian development until mid gestation.

  2. Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.

  3. cloned a mouse homolog of the human SIL promoter

Xenopus laevis SCL/TAL1 Interrupting Locus (STIL) Interaktionspartner

  1. Scl (zeige TAL1 ELISA Kits) is required for the programming of adult haemangioblasts.

Zebrafish SCL/TAL1 Interrupting Locus (STIL) Interaktionspartner

  1. decreased expression of Stil resulted in increased toxic susceptibility of retinal dopaminergic cells to 6-hydroxydopamine

  2. Scl (zeige TAL1 ELISA Kits)/Lmo2 (zeige LMO2 ELISA Kits) complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other

  3. These data, taken together, identify SIL as a novel, vertebrate-specific regulator of mitotic spindle assembly.

STIL Antigen-Profil

Beschreibung des Gens

This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with STIL

  • Scl/Tal1 interrupting locus (Stil) Elisa Kit
  • SCL/TAL1 interrupting locus (STIL) Elisa Kit
  • SCL/TAL1 interrupting locus (stil) Elisa Kit
  • TAL1 (SCL) interrupting locus (stil) Elisa Kit
  • chunp6907 Elisa Kit
  • MCPH7 Elisa Kit
  • SIL Elisa Kit
  • sill Elisa Kit
  • zgc:110502 Elisa Kit

Bezeichner auf Proteinebene für STIL

Tal1 interrupting locus , SCL-interrupting locus protein , TAL-1-interrupting locus protein , SCL-interrupting locus protein homolog , TAL1 (SCL) interrupting locus like , cassiopeia , csp , nbb

313506 Rattus norvegicus
510012 Bos taurus
6491 Homo sapiens
20460 Mus musculus
431864 Xenopus laevis
192317 Danio rerio
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