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Strikingly, human pluripotent stem cell antibody array showed that Hand1 overexpression resulted in substantial decrease in pluripotency markers (Nanog (zeige NANOG ELISA Kits), Oct3/4 (zeige POU5F1 ELISA Kits), Otx2 (zeige OTX2 ELISA Kits), Flk1 (zeige KDR ELISA Kits)) suggesting that Hand1 expression may be essential to attenuate the EMT (zeige ITK ELISA Kits) and our findings underscore a novel role for Hand1 in medulloblastoma metastasis.
association of HAND1 loss-of-function mutation with increased susceptibility to Tetralogy of Fallot
These findings expand the phenotypic spectrum linked to HAND1 mutations, suggesting potential implications for the development of novelo prophylactic and therapeutic strategies for DORV.
HAND1 loss-of-function mutation is associated with familial dilated cardiomyopathy.
Combined expression of NKX2-5 (zeige NKX2-5 ELISA Kits), HAND1, and NOTCH1 (zeige NOTCH1 ELISA Kits) coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome.
These data show that miR (zeige MLXIP ELISA Kits)-363 negatively regulates the expression of HAND1
Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors.
DNA methylation (zeige HELLS ELISA Kits) status of NKX2-5 (zeige NKX2-5 ELISA Kits), GATA4 (zeige GATA4 ELISA Kits) and HAND1 in patients with tetralogy of fallot
Increased methylation levels of HAND1 is associated with highly active Helicobacter pylori-related gastritis.
This is the first report of mutations in the HAND1 gene in Chinese patients with VSD and provides new insight into the etiology of VSD
a single nucleotide substitution in the hand1.S promoter was responsible for the reduced expression in the heart.
increased vascular endothelial growth factor(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis
a non-essential role for Hand1 in mouse limb morphogenesis, is reported.
Surviving Hand1;Hand2 (zeige HAND2 ELISA Kits) mutants display diminished cardiac function that is rescued by concurrent ablation of Hand-null cardiomyocytes. Collectively, we conclude that, within a mixed cardiomyocyte population, removal of defective myocardium and replacement with healthy endogenous cardiomyocytes may provide an effective strategy for cardiac repair.
Within the pharyngeal arches, the distal-most of the proximo-distally oriented subdomains of cranial neural crest cells, the distal cap, is marked by expression of the transcription factor Hand1 and gives rise to the ectomesenchymal derivatives of the lower incisors.
Data suggest the protection role of haploinsufficiency of heart and neural crest derivatives expressed transcript 1 protein (Hand1) after acute myocardial infarction (AMI (zeige CFD ELISA Kits)).
Hand1 is involved in proper osteogenesis of the bone collar via its control of Ihh (zeige IHH ELISA Kits). Hand1 overexpression in the osteochondral progenitors caused defective prenatal diaphysis ossification. Hand1 inhibited Runx2 (zeige RUNX2 ELISA Kits) transactivation of the Ihh (zeige IHH ELISA Kits) proximal promoter.
Re-expression of HAND1 in colon cancer cells induces terminal differentiation.
Hand1 phosphoregulation in the distal arch neural crest has a critical role in craniofacial morphogenesis
Suggest that prenatal alcohol exposure causes the over-expression of DHAND (zeige HAND2 ELISA Kits) and EHAND by increasing H3K14ac in the fetal heart.
Hand1 is part of a novel regulatory pathway linking cardiac oxygen levels with oxygen consumption.
that Hand1 homodimer plays a dominant role during development and its expression dosage is critical for survival, whereas Hand1 heterodimers can be either dispensable or play a regulatory role to modulate the activity of Hand1 homodimer in vivo.
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.
class A basic helix-loop-helix protein 27
, extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1
, heart- and neural crest derivatives-expressed protein 1
, heart and neural crest derivatives expressed transcript 1
, heart and neural crest derivatives-expressed protein 1
, heart and neural crest derivatives expressed 1
, basic helix-loop-helix transcription factor HAND1
, eHAND basic helix-loop-helix transcription factor
, Heart- and neural crest derivatives-expressed protein 1
, helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast