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Novel mercaptoacetamide-based class II histone deacetylase (zeige HDAC1 ELISA Kits) inhibitor HDACIW2 treatment regulated the levels of RasGRF1 (zeige RASGRF1 ELISA Kits) and p-ERK (zeige EPHB2 ELISA Kits), and that W2 requires RasGRF1 (zeige RASGRF1 ELISA Kits) and ERK (zeige EPHB2 ELISA Kits) signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1 (zeige RASGRF1 ELISA Kits)/ERK (zeige EPHB2 ELISA Kits)-dependent signaling pathway
p190A acts as a modulator of Rho GTPases in a localized area around the cilia to permit the dynamic actin rearrangement required for cilia elongation.
Data (including data from studies in knockout mice) suggest mechanisms involving RasGRF1 (zeige RASGRF1 ELISA Kits) exist to regulate hypothalamic-pituitary-adrenal axis in early-adolescent females; such mechanisms appear absent in younger/older female or adolescent male mice.
VLDLR (zeige VLDLR ELISA Kits) requires RasGRF1 (zeige RASGRF1 ELISA Kits)/CaMKII (zeige CAMK2G ELISA Kits) to alter dendritic spine formation.
Study suggests a complex role of ERK (zeige EPHB2 ELISA Kits)-dependent and Ras-GRF1 (zeige RASGRF1 ELISA Kits)-dependent signaling in corticostriatal plasticity, highlights differences between synaptic mechanisms in naive slices and dopamine-depleted preparations from L-DOPA-treated dyskinetic animals
RasGrf1 (zeige RASGRF1 ELISA Kits) is an important upstream component of signal transduction pathways regulating Pttg1 (zeige PTTG1 ELISA Kits) expression and controlling beta cell development and physiological responses.
CARD9 (zeige CARD9 ELISA Kits) regulates H-Ras (zeige HRAS ELISA Kits) activation by linking Ras-GRF1 (zeige RASGRF1 ELISA Kits) to H-Ras (zeige HRAS ELISA Kits), which mediates Dectin-1 (zeige CLEC7A ELISA Kits)-induced extracellular signal-regulated protein kinase (zeige CDK7 ELISA Kits) (ERK (zeige EPHB2 ELISA Kits)) activation and proinflammatory responses when stimulated by their ligands.
GRF1 is expressed in new neurons when GRF1 loss begins to effect neuronal function, promoting late stages of adult neurogenesis. GRF1 is an age-dependent regulator of adult hippocampal neurogenesis and the ability to distinguish closely related contexts.
Data indicate that contextual discrimination involves term potentiation (LTP (zeige SCP2 ELISA Kits)) promoted by calcium-permeable AMPA (zeige GRIA3 ELISA Kits)-type glutamate (zeige GRIN1 ELISA Kits) receptors, RAS-GRF1 (zeige RASGRF1 ELISA Kits) and p38 MAP kinase (zeige MAPK14 ELISA Kits).
The cellular RacGAP activity of p190RhoGAP requires an intact polybasic region adjacent to the GAP domain whereas the RhoGAP (zeige ARHGAP1 ELISA Kits) activity is inhibited by the same domain.
report association of APOE (zeige APOE ELISA Kits) and TOMM40 (zeige TOMM40 ELISA Kits) with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 (zeige SERPINA1 ELISA Kits) with progressive non-fluent aphasia.
interaction involves the first FF motif of p190A and the winged helix/PCI (zeige SERPINA5 ELISA Kits) domain of eIF3A (zeige EIF6 ELISA Kits), is enhanced by serum stimulation and reduced by phosphatase treatment
these data demonstrate that a complex of p190RhoGAP-A and anillin (zeige ANLN ELISA Kits) modulates RhoA (zeige RHOA ELISA Kits)-GTP (zeige AK3 ELISA Kits) levels in the cytokinetic furrow to ensure progression of cytokinesis.
These results place Blk (zeige BLK ELISA Kits) upstream of the p190RhoGAP-RhoA (zeige RHOA ELISA Kits) pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12 (zeige CXCL12 ELISA Kits)-triggered invasion.
ARHGAP35 rs1052667 polymorphism was an independent prognostic factor influencing the survival of osteosarcoma.
GRF-1 expression may modify osteosarcoma prognosis and may be a potential tumor therapeutic target.
A ubiquitous binding partner of p190RhoGAP, p120RasGAP (RasGAP (zeige RASA1 ELISA Kits)), is expressed in much lower levels in DKO4 cells compared to DLD1, and this expression is regulated by KRAS.
Overexpression of p190 (zeige CNTNAP1 ELISA Kits) mRNA associated with lung adenocarcinoma.
These data suggest that the interaction of human papillomavirus E7 with p190 dysregulates this GTPase activating protein and alters the actin cytoskeleton.
RhoA (zeige RHOA ELISA Kits) is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis.
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.
glucocorticoid receptor DNA binding factor 1
, rho GTPase-activating protein 35
, P190 RhoGAP
, glucocorticoid receptor DNA-binding factor 1
, GRF beta
, Ras guanine release factor beta
, guanine nucleotide releasing factor 1
, guanine nucleotide-releasing protein
, ras-specific guanine nucleotide-releasing factor 1
, ras-specific nucleotide exchange factor CDC25
, glucocorticoid receptor repression factor 1
, rho GAP p190A
, GAP-associated protein p190