Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
This paper reports a novel skull phenotype in a ciliopathic mutant mouse in which only a single calvarial bone plate encases the forebrain in mice lacking Fuz, an essential regulator of ciliogenesis.
Fuzzy appears to control subcellular localization of the core PCP (zeige BMP1 ELISA Kits) protein Dishevelled (zeige DVL2 ELISA Kits), recruiting it to Rab8 (zeige RAB8A ELISA Kits)-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP (zeige BMP1 ELISA Kits) signaling
Using the ciliopathic Fuz mutant mouse, we find that high arched palate does not, as commonly suggested, arise from midface hypoplasia; rather, increased neural crest expands the maxillary primordia.
The data demonstrate a new model for coordination of Hh and Wnt (zeige WNT2 ELISA Kits) signaling and reveal a Fuz-dependent negative feedback loop controlling Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling.
Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia.
Fuz plays an important role in cilia formation, Hh signal transduction, and embryonic development in mammals.
This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene.
fuzzy homolog (Drosophila)
, protein fuzzy homolog
, fuzzy homolog