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The results suggest that CITED2 mutations in conserved regions lead to disease-causing biological and functional changes and may contribute to the occurrence of conotruncal heart defects in Chinese children.
CITED2 gene mutation may play a significant role in the development of pediatric congenital heart disease.
CITED2 supports gastric cancer cell colony formation and proliferation while inhibiting apoptosis making it a potential gene therapy target for gastric cancer.
Through allosteric enhancement of HIF-1alpha (zeige HIF1A Proteine) release, CITED2 activates a highly responsive negative feedback circuit that rapidly and efficiently attenuates the hypoxic response, even at modest CITED2 concentrations.
down-regulation of Cited2 was associated with high glucose-induced apoptosis in cardiomyocytes in vitro
High Cited2 level in cumulus cells was associated with low embryo quality and pregnancy outcome in in vitro fertilization patients.
the downregulation of CITED2 contributes to TGFbeta (zeige TGFB1 Proteine)-mediated senescence.
CITED2 plays important roles in the progression and chemoresistance of breast carcinoma and that CITED2 status is a potent prognostic factor in breast cancer patients.
Intrinsic protein disorder plays a prominent role in the function and interactions of the transcriptional co-activators CBP (zeige CREBBP Proteine) and p300 (zeige EP300 Proteine). (Review)
FBXL5 (zeige FBXL5 Proteine)-mediated degradation of CITED2 leads to the activation of HIF-1 alpha (zeige HIF1A Proteine).
CITED2 and ISL1 (zeige ISL1 Proteine) proteins interact physically and cooperate to promote embryonic stem cell differentiation toward cardiomyocytes.
ectopic CITED2 expression at the onset of the reprogramming process in combination with the reprogramming factors promotes a complete and homogeneous conversion of somatic cells into induced pluripotent stem cells
This study demonstrated that Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity in mice.
Study showed a novel function of miR (zeige MLXIP Proteine)-200b and CITED2 in high glucose-induced unfolded protein response and ER stress, suggesting that miR (zeige MLXIP Proteine)-200b and CITED2 are critical for ER homeostasis and neural tube defect formation in the developing embryo.
MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2 (zeige MEF2C Proteine))-regulated Gtl2-Dio3 (zeige DIO3 Proteine) Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2.
Cited2 is required for and enhances reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells.
Cited2 is required for the maintenance of adult hematopoietic stem cell glycolytic metabolism likely through regulating Pdk2 (zeige PDK2 Proteine), Pdk4 (zeige PDK4 Proteine), lactate dehydrogenases B and D, and Akt (zeige AKT1 Proteine) activity.
Cited2 in sinusoidal trophoblast giant cells and syncytiotrophoblasts is likely to have a non-cell autonomous role in patterning of the pericytes associated with the embryonic capillaries.
a deletion of Cited2 in mESCs results in abnormal mitochondrial morphology and impaired glucose metabolism, which correlates with a defective cell fate decision.
CITED2 is phosphorylated by MAPK1 (zeige MAPK1 Proteine) in vitro at T166, and that MAPK1 (zeige MAPK1 Proteine) activation enhances the coactivation function of CITED2 but not of CITED2-T166N.
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, cbp/p300-interacting transactivator 2
, Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
, similar to Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal
, Cbp/p300-interacting transactivator 2
, MSG-related protein 1
, MSG1-related gene 1
, melanocyte-specific gene 1-related gene 1
, melanocyte specific gene 2
, cited2/melanocyte specific gene-related gene 1 MRG1