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Our study concludes that the splice site variant identified in the ALX1 gene causes mild form of Frontonasal dysplasia.
we identify critical roles of ALX1 in lung cancer development and progression
Knockdown of the CART1 gene significantly inhibited cell invasion and proliferation and induce cell cycle arrest in S phase.
we found that depletion of ALX1 caused a dramatic cell cycle arrest, followed by massive apoptotic cell death, and eventually resulted in a significant decrease in migration and invasion of the osteosarcoma cell line studied.
hypermethylation of HIST1H4F, PCDHGB6 (zeige PCDHgB6 ELISA Kits), NPBWR1 (zeige NPBWR1 ELISA Kits), ALX1, and HOXA9 (zeige HOXA9 ELISA Kits) was significantly associated with shorter survival in stage 1 Non-small-cell lung cancer
ALX1 upregulated expression of the key EMT (zeige ITK ELISA Kits) regulator Snail (SNAI1 (zeige SNAI1 ELISA Kits)) and that it mediated EMT (zeige ITK ELISA Kits) activation and cell invasion by ALX1.
Disruption of CART1 (ALX1) causes extreme microphthalmia and severe facial clefting.
Scapula development is governed by genetic interactions of Pbx1 (zeige PBX1 ELISA Kits) with its family members and with Emx2 (zeige EMX2 ELISA Kits) via their cooperative control of Alx1
We now demonstrate the function of the aristaless domain in vivo by ectopically expressing normal and mutated forms of Cart1 (zeige TRAF4 ELISA Kits) and Alx3 (zeige ALX3 ELISA Kits)
p300/CBP (zeige CREBBP ELISA Kits) stimulate Cart1 (zeige TRAF4 ELISA Kits)-dependent transcription activity, and this transactivation is inhibited by E1A (zeige BCKDHA ELISA Kits) and Tax (zeige CNTN2 ELISA Kits), oncoproteins that suppress the activity of p300/CBP (zeige CREBBP ELISA Kits)
The specific function of this gene has yet to be determined in humans\; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly.
ALX homeobox 1
, cartilage paired-class homeoprotein 1
, ALX homeobox protein 1
, ALX homeobox protein 1-like
, cartilage homeo protein 1
, cartilage homeoprotein 1