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Syx5 plays an essential role in copper homeostasis through Ctr1A and is a candidate gene for copper-related disease in humans
dSyx5 is required for the proper function of the Golgi apparatus and that an efficiently functioning Golgi apparatus is required for the steps leading to the completion of cytokinesis and formation of mature sperm.
Expression of the Syn5 (zeige SNTG2 ELISA Kits) K270R mutant in cells impairs post-mitotic Golgi reassembly
Together, these data strongly suggest that syntaxin 5-mediated retrograde transport to the Golgi apparatus is a broadly conserved feature of adeno (zeige ADORA2A ELISA Kits)-associated virus trafficking.
Stx5 might play a role in modulating VLDL-R (zeige VLDLR ELISA Kits) physiology by participating in an abrasively described or completely novel Golgi-bypass pathway.
serum anti-STX5 autoantibody, which was discovered by a proteomic approach, is a potential new serum marker for the diagnosis of endometriosis.
Depletion of syntaxin-5 complex components results in the accumulation of autophagosomes as a result of lysosomal dysfunction, leading to decreased degradation of autophagic substrates.
Syx5 is required for the maintenance of the Golgi structures but may not play a major role in the transport of vesicles carrying proteins between the ER and the Golgi compartment.
hypothesize that syntaxin 5 also has trafficking-independent functions
depletion of GM130 (zeige GOLGA2 ELISA Kits) by RNA interference slows the rate of ER to Golgi trafficking in vivo; interactions of GM130 (zeige GOLGA2 ELISA Kits) with syntaxin 5 and Rab1 (zeige RAB1A ELISA Kits) are regulated by mitotic phosphorylation
Study shows that the SM protein, Sly1, interacts directly with the conserved oligomeric Golgi (COG (zeige TG ELISA Kits)) tethering complex; Sly1-COG (zeige TG ELISA Kits) interaction is mediated by the Cog4 (zeige COG4 ELISA Kits) subunit, which also interacts with Syntaxin 5 through a different binding site.
Pkd2 (zeige PKD2 ELISA Kits) in the ER plays a role in cellular Ca(2 (zeige CA2 ELISA Kits)+) homeostasis and Stx5 functions to inactivate Pkd2 (zeige PKD2 ELISA Kits) and prevent leaking of Ca(2 (zeige CA2 ELISA Kits)+) from ER stores
This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, syntaxin 5
, syntaxin 5A
, syntaxin 5a