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Our data suggest that the D543N variant of SLC11A1 gene has a protective effect in the development of rheumatoid arthritis in a Mexican Mestizo population
SLC11A1 expression is significantly upregulated in human masticatory mucosa during wound healing
We found a statistical association between polymorphisms in 3'UTR (zeige UTS2R ELISA Kits) region and exon 8 and CL [chi(2) = 13.26; p < 0.05; OR = 17.00; IC of 95% (2.24-128.99)]. Some patients who needed more than 40 doses of Glucantime(R) to heal injuries presented mutations in exons 3, 8, and 15. Multiple or ear lesions were not associated with NRAMP1 polymorphism.
distriburtion of polymorphism allelle frequency at the INT4 (zeige WNT3 ELISA Kits) region associated with oropharyngeal tularemia
we conclude that presence of G allele of NRAMP1 in both rs2276631 and rs17235409 location may be a protective factor against chronic periodontitis
our meta-analysis demonstrated that no significant association was identified between genetic susceptibility to UC/CD and polymorphisms of NRAMP1 gene, including (GT)n allele 2, 274 C/T, 1729+55del4 (TGTG) +/del in overall population.
The ratio of FoxA1 (zeige FOXA1 ELISA Kits) to FoxA2 (zeige FOXA2 ELISA Kits) in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor (zeige ASH1L ELISA Kits) LSH (zeige HELLS ELISA Kits)
The 274C/T polymorphism in exon 3 and the 469+14G/C polymorphism in intron 4 of the Slc11a1/Nramp1 gene were associated with susceptibility to leprosy, while the allele 2 and 3 of the (GT)n polymorphism in the promoter region were associated with susceptibility and protection to leprosy, respectively.
investigation of NRAMP1, MBL (zeige MBL2 ELISA Kits), MBL (zeige MBL2 ELISA Kits), VDR (zeige CYP27B1 ELISA Kits) gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis in a Chinese population; study suggests that genotypes of many polymorphic genes are associated with TB
No significant difference was found for NRAMP1 and hGPX1 gene polymorphisms associated with recurrence time.
Study shows that, before and after weaning, Nramp1 was highly expressed in digestive (stomach) and intestinal (duodenum, jejunum, and ileum) tissues, further indicating a genetic role in both immune regulation to compensate for weaning stress and enhanced development of intestinal immunity.
The frequency of allele B and A was 0.93 and 0.90 on a total of 180 and 205 pigs for the polymorphism in intron 1 and intron 2 of the Nramp1 gene respectively in a mixed population of hybrid and purebred pigs.
Genomic organization and polymorphisms detected by denaturing HPLC of porcine NRAMP1 gene are reported.
a significant correlation between different genotypes of Nramp1 gene and immune function and production performance
Polymorphisms in SLC11A1 and CXCR1 (zeige CXCR1 ELISA Kits) are significantly associated with bovine mastitis
Analysis of allelic variants in the first and second microsatellite at the 3;UTR (zeige UTS2R ELISA Kits) region of the SLC11A1 gene in cattle breeds present in Argentina.
Preferential expression of SLC11A1 transcripts in gammadelta T cells is detected in bovine, human, and mouse gammadelta T cells.
NRAMP1 consists of multiple targeting motifs for trafficking into lysosomes.
DNA sequence analysis of NRAMP1 gene polymorphisms from 5 different cattle breeds
Identification of a novel polymorphism within the bovine NRAMP 1 gene intron X.
Study compared the frequency of Nramp1 3'UTR (zeige UTS2R ELISA Kits) polymorphisms between Zebu and European bovine breeds.
The expression of iNOS (zeige NOS2 ELISA Kits) and NRAMP1 in the lymph nodes, lungs, and tuberculous granulomas in 8 bovine tuberculosis cases is reported.
These results indicate that these polymorphisms at the NRAMP1 3'UTR (zeige UTS2R ELISA Kits) do not affect resistance against B. abortus in cattle.
Genotype of the SLC11A1 gene is associated with resistance to brucellosis.
discrete, anatomically localized host resistance is conferred by Nramp1 expression; restriction of systemic bacterial growth in the spleen is enhanced by Nramp1 expression
Data shows that Lsh (zeige HELLS ELISA Kits) plays an essential Dnmt3b (zeige DNMT3B ELISA Kits)-independent role to ensure that the host genome integrity is protected from potentially deleterious LTR retroelements.
Gene expression profiles of the two arthritis quantitative trait loci (on chromosomes 5 and 8) correlate with Slc11a1 alleles, resulting in enhanced AIRmax(SS) mice susceptibility to Pristane-induced arthritis.
In the absence of LSH, the histone variant H2AX is not efficiently phosphorylated in response to DNA damage.
These observations indicate a bifunctional protective role of secretory Prx (zeige PRX ELISA Kits); first it reduces redox activation of macrophages, and secondly it allows iron access to Leishmania by down regulating NRAMP1 expression.
Stimulation of Lcn2 (zeige LCN2 ELISA Kits) expression is a novel mechanism by which Nramp1 confers resistance against infection with Salmonella typhimurium.
High inflammatory AIRmax mice homozygous for Slc11a1 R and S alleles were produced. The Slc11a1 gene modulated the early inflammatory events of ear tissue regeneration.
anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin (zeige HAMP ELISA Kits) expression, is influenced by Nramp1 and may involve lipocalin-2 (zeige LCN2 ELISA Kits).
The Yersinia pseudotuberculosis mntH mutant was defective in survival and growth in macrophages expressing functional Nramp1, but in macrophages deficient in Nramp the bacteria were able to survive and replicate.
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
, natural resistance associated macrophage protein 1
, natural resistance-associated macrophage protein 1
, natural resistance-associated macrophage protein 1-like
, NRAMP 1
, solute carrier family 11 (sodium/phosphate symporters), member 1
, solute carrier family 11 member 1
, host resistance locus Bcg/Ity/Lsh
, natural resistant-associated macrophage protein 1
, natural resistance associated macrophage protein