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AtFH binds and modulates Nfs1 kinetics in mitochondria.
NFS1 has a role in mediating the assembly of iron-sulfur clusters in mitochondria.
CpNifS was sufficient for Fe-S cluster formation in ferredoxin in the presence of cysteine and a ferrous iron salt. [CpNifS]
overexpression of this plant NifS-like protein had a pronounced effect on plant Se metabolism
CpNifS is necessary for the maturation of all plastidic Fe-S proteins and, thus, essential for plant growth
human NFS1 was almost fully able to complement the role of IscS in Moco biosynthesis when its specific interaction partner protein MOCS3 (zeige MOCS3 Proteine) from humans was also present.
The NFS1/ISD11 (zeige LYRM4 Proteine) complex further interacts with scaffold protein (zeige HOMER1 Proteine) ISCU (zeige ISCU Proteine) and regulator protein frataxin (zeige FXN Proteine), thereby forming a quaternary complex for Fe-S cluster formation.
FDX1 (zeige FDX1 Proteine) and FDX2 (zeige FDX1L Proteine) both bind NFS1 and donate electrons for iron-sulfur cluster biosynthesis.
Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (zeige FXN Proteine)(42-210)]24.[NFS1]24.[ISD11 (zeige LYRM4 Proteine)]24.[ISCU (zeige ISCU Proteine)]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.
Our findings highlight that the ISD11 (zeige LYRM4 Proteine) R68A/R68L mutation display reduced affinity to form a stable subcomplex with NFS1, and thereby fails to prevent NFS1 aggregation resulting in impairment of the Fe-S cluster biogenesis
The data presented here show that the Isu1 suppressor mimics the frataxin (zeige FXN Proteine) effects on Nfs1, explaining the bypassing activity.
NFS1 binds preferentially to the D-state of ISCU (zeige ISCU Proteine) while mtHSP70 (zeige HSPA9 Proteine) binds preferentially to the D-state of ISCU (zeige ISCU Proteine) and HSC20 (zeige HSCB Proteine) binds preferentially to the S-state of ISCU (zeige ISCU Proteine).
the interaction of NFS1 and MOCS3 (zeige MOCS3 Proteine) in the cytosol of human cells, is reported.
Nfs1, the cysteine desulfurase responsible for providing sulfur for cluster formation, is required for the increased Isu stability occurring after disruption of cluster formation on or transfer from Isu
the cytosolic form of ISCS is a functional cysteine desulfurase that can collaborate with cytosolic ISCU (zeige ISCU Proteine) to promote de novo iron-sulfur cluster formation
there is a mechanism that primarily dedicates m-Nfs1 to the biogenesis of mitochondrial Fe-S clusters in order to maintain cell survival
While IFN-gamma (zeige IFNG Proteine) alone induced Nfs1 protein instability, LPS (zeige TLR4 Proteine) triggered a delayed decline of Nfs1, rather involving transcriptional events or mRNA instability.
Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described.
cysteine desulfurase NFS1
, cysteine desulfurase, (m-Nfs1)
, cysteine desulfurase
, NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
, NFS1 nitrogen fixation 1 homolog
, cysteine desulfurase, mitochondrial
, nitrogen fixation 1 (S. cerevisiae, homolog)
, nitrogen-fixing bacteria S-like protein
, nitrogen fixation gene 1
, nifS-like (sic)
, nitrogen fixation gene, yeast homolog 1