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Knocking down HYAL2 in HUVECs protected against HA degradation in the glycocalyx by inhibiting the expression and activity of HYAL2 and further blocked the dephosphorylation of eNOS (zeige NOS3 ELISA Kits)-Ser (zeige SIGLEC1 ELISA Kits)-633 and the decrease in NO production in response to LSS (zeige LSS ELISA Kits).
HYAL2 mutations identified as a cause of syndromic orofacial clefting and cor triatriatum sinister in amish families.
our data uncover a previously unsuspected mechanism of how hyaluronan and Hyal-2 control platelet generation.
Data show that DNA methylation (zeige HELLS ELISA Kits) at CpG island of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil chemotherapy with respect to progression-free survival.
CD44 (zeige CD44 ELISA Kits) knock-down in bovine and human chondrocytes results in release of bound HYAL2.
High expression of S100P (zeige S100P ELISA Kits) and HYAL2 is significantly associated with advanced disease and shorter survival of triple-negative breast cancer and S100P (zeige S100P ELISA Kits) and HYAL2 could be potential prognostic markers of TNBC.
HYAL2 plays a redundant role in the catalysis of megadalton HA to its 20 kDa intermediate during fertilization.
Lower platelet HYAL2 levels and activity are associated with inflammatory bowel disease.
A strong association between decreased HYAL2 methylation in peripheral blood and BC.
Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.
Hyal2(-/-) mice have increased hyaluronan, which may promote endothelial-to-mesenchymal transition and proliferation of mesenchymal cells leading to congenital heart defects and heart failure.
It was concluded that: HYAL1 (zeige HYAL1 ELISA Kits) and HYAL2 are both needed for tissue HA catabolism; 2) HYAL2 is required for high MW HA clearance in lymph nodes and plasma and for HA endocytosis by liver NPCs; and 3) the main role of HYAL1 (zeige HYAL1 ELISA Kits) is HA degradation within liver NPCs.
Hyal2-/- mice present craniofacial abnormalities, including submucosal cleft palate and incompletely penetrant cor triatriatum sinister with hearing loss.
Removal of Hyal2 activity resulted in increased levels of hyaluronan creating a risk for cor triatriatum sinister.
hyaluronidase 2 deficiency induces chronic thrombotic microangiopathy with hemolytic anemia in mice.
HYAL1 (zeige HYAL1 ELISA Kits) is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 is essential for the degradation of extracellular HA in all kidney regions
Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction
Hyal-2 enhancement of tumor necrosis factor-alpha (zeige TNF ELISA Kits)-stimulated cytotoxicity in fibroblasts is blocked by Transforming growth factor-beta1.
HYAL2 expression improves the blastocyst rate and embryo quality, an effect which requires CD44 (zeige CD44 ELISA Kits) activity and MAPK (zeige MAPK1 ELISA Kits) signaling.
May degrade hyaluronan by analogy to human HYAL2, which is a weak acid-active hyaluronidase (zeige HAase ELISA Kits). Serves as an entry receptor for jaagsiekte sheep retrovirus in sheep and bovine as well as for enzootic nasal tumor virus in sheep.
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
hyaluronidase 2 b
, hyaluronoglucosaminidase 2
, hyaluronidase 2
, hyaluronidase 2 a
, PH-20 homolog
, PH20 homolog
, lung carcinoma protein 2
, lysosomal hyaluronidase
, GPI-anchored surface protein
, JSRV envelope protein receptor