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Human Haptoglobin Protein expressed in Human - ABIN3119691
Eshbach, Kaur, Rbaibi, Tejero, Weisz: Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease. in American journal of physiology. Cell physiology 2017
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Human Haptoglobin Protein expressed in Human - ABIN3119693
Fatunmbi, Abzalimov, Savinov, Gershenson, Kaltashov: Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry. in Biochemistry 2016
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Human Haptoglobin Protein expressed in Human - ABIN491578
Zapotoczna, Heilbronner, Speziale, Foster: Iron-regulated surface determinant (Isd) proteins of Staphylococcus lugdunensis. in Journal of bacteriology 2012
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Although better control may reduce the incidence of coronary artery disease in Type 1 diabetes, a residual risk related to the haptoglobin 2 allele remains.
Regardless of the haptoglobin genotype, haptoglobin is associated with prevention of endothelial cell apoptosis in diabetes.
study discovered a splice donor founder mutation in HP (NM_001126102.1:c.190 + 1G > C); this mutation occurs on the HP1 (zeige DEFA1 Proteine) allele of the common copy number variant in HP and leads to loss of function of HP1 (zeige DEFA1 Proteine); it associates with lower levels of haptoglobin, higher levels of non-high density lipoprotein cholesterol and greater risk of coronary artery disease
the minor allele (T) of rs8062041 appeared to be protective against African Trypanosomiasis; haptoglobin related protein (HPR (zeige HPR Proteine)) is adjacent to HP and is a component of the Trypanolytic factor; the HP and HPR (zeige HPR Proteine) locus is duplicated in some people; the rs8062041 variant may be associated with this duplication and it is possible that increased production of HPR (zeige HPR Proteine) is the cause of protection associated with rs806204
These results suggest that the hippocampus of Hp 1 (zeige DEFA1 Proteine)-1 genetic carriers may be more vulnerable to the insults of poor glycemic control.
Our results show an association between increased early-pregnancy serum zonulin concentration and gestational diabetes, suggesting zonulin as a possible predictor for gestational diabetes.
Pilot study shows an association of the haptoglobin 2-2 genotype with low-grade inflammation, haptoglobin concentration and carotid artery intima-media thickness in multi-ethnic population from Singapore.
We conducted a replication study using a dataset outside of the Challenge, and found the association between TP53INP2 (zeige TP53INP2 Proteine) and ER-negative breast cancer was significant (p = 5.07x10-3). Expression of HP (16q22.2) showed a suggestive association with ER-negative breast cancer in the discovery phase (Z = 4.30, p = 1.70x10-5) although the association was not significant after Bonferroni adjustment.
Studies suggest an association of serum haptoglobin N-glycan variation with gastric cancer and might be a promising marker for the cancer screening.
These results were consistent with the data of the clinical specimens. miR (zeige MLXIP Proteine)-122a could be a positive factor of zonulin by targeting EGFR (zeige EGFR Proteine), which increased the intestinal epithelial permeability in vivo and in vitro.
These data demonstrate that serum neutrophil haptoglobin-MMP 9 (zeige MMP9 Proteine) complexes appear sooner and decline more rapidly than other acute phase proteins.
An increase in serum amyloid A or haptoglobin in dairy cows with abomasal displacementis not specific for inflammation or bacterial infection; increased levels of either may indicate the presence of hepatic lipidosis.
Haptoglobin concentration may be a useful indicator for cows with postpartum reproductive disorders.
Presence in the milk of the acute phase proteins (APP (zeige APP Proteine)), haptoglobin (Hp) and serum amyloid A to see the relationships in cow composite and bulk tank milk samples.
Bovine granulocytes, isolated from peripheral blood of healthy cattle, contain abundant amounts of haptoglobin within the granules.
This study suggests that neutrophils and epithelial cells may play an essential role in elevating milk haptoglobin (Hp) in addition to previous suggestions that Hp may be derived from mammary tissues and circulation.
Data show that zonulin-dependent small intestinal barrier impairment is an early step leading to the break of tolerance with subsequent development of chronic inflammatory diseases (CIDs).
the interaction between haptoglobin genotype and vitamin E affects atherosclerotic plaque progression and stability
Exogenous haptoglobin attenuated the HbA (zeige HBA-A1 Proteine)-induced HO-1 (zeige HMOX1 Proteine) expression in vitro and in mouse model of sickle cell disease.
Suggest haptoglobin is an enhancer of inflammation after cardiac transplantation, contributing to graft rejection.
Zonulin facilitates development of acute lung injury (ALI) both by enhancing albumin (zeige ALB Proteine) leak and complement activation as well as increased buildup of neutrophils and cytokines during development of ALI.
Haptoglobin deficiency is associated with leakage-prone vessels via isolated VEGFA (zeige VEGFA Proteine) induction and/or suppressed Ang-1 (zeige ANGPT1 Proteine) expression, resulting in unbalanced VEGFalpha/Ang-1 (zeige ANGPT1 Proteine) transcription.
the Hp2-2 protein is involved in aneurysm formation and that the Hp genotype may be a useful biomarker in predicting aneurysm progression
Experimental models of colitis showed that haptoglobin has a protective role in inflammatory colitis
these studies provide direct evidence that the increased oxidative stress in Hp 2-2 atherosclerotic plaques is due to hemoglobin derived iron.
Synthetic PPAR gamma (zeige PPARG Proteine) ligands selectively activate PPAR gamma (zeige PPARG Proteine) bound to the haptoglobin gene promoter to arrest haptoglobin gene transcription.
crystal structure of the dimeric porcine haptoglobin-haemoglobin complex determined at 2.9 A resolution
haptoglobin has a role in oxidative status in piglets undergoing weaning-induced stress
This study suggested closer links between the release of haptoglobin, Pig-MAP and monocytes compared to the release of AGP, SAA (zeige SAA1 Proteine) and transthyretin (zeige TTR Proteine).
The haptoglobin was down-regulated with SNPs
Surfactant protein D (zeige SFTPD Proteine) and haptoglobin serum concentrations could be a diagnostic aid for equine inflammatory airway disease.
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
, binding peptide
, haptoglobin alpha(1S)-beta
, haptoglobin alpha(2FS)-beta
, haptoglobin, alpha polypeptide
, haptoglobin, beta polypeptide
, liver regeneration-related protein LRRG173
, haptoglobin-related protein
, haptoglobin alpha 1S