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ABCG2 rs3114020 might be one of the candidate biomarkers for non-small cell lung cancer survival in this Chinese population, especially among patients with adenocarcinoma.
Results indicated that OCT1 rs628031 and ABCG2 rs2231142 were associated with plasma lamotrigine concentrations in Han Chinese patients with epilepsy.
Variation in ABCG2 function may play a role in the development of tophaceous disease in some populations with high prevalence of severe gout.
This study provides novel insight into the regulation of the placental BCRP transporter by hypoxia, which may be important for exposure of the fetus to chemicals during early development and in hypoxia-related pregnancy disorders.
Overexpression of augmenter of liver regeneration (ALR (zeige GFER ELISA Kits)) in liver cancer was studied and found to improve sensitivity to antitumor drugs by increasing the retention of intracellular drugs, at least partly through the modulation of the ABCB1 (zeige ABCB1 ELISA Kits) and ABCG2 signaling pathway.
These results suggest that PPARgamma (zeige PPARG ELISA Kits) can upregulate BCRP expression in the placenta, which may be important in understanding mechanisms that protect the fetus from xenobiotic exposure during development.
The percentage of positive cells for ABCG2 protein marker increased significantly from LPC0 to LPC1 (zeige ANXA1 ELISA Kits), but then decreased significantly in LPC2 (zeige ANXA2 ELISA Kits).
The difference in the Wnt (zeige WNT2 ELISA Kits) microenvironment in AC and SCC (zeige CYP11A1 ELISA Kits) leads to variations in ABC transporter expression. Cisplatin via induction of canonical Wnt (zeige WNT2 ELISA Kits) signaling up-regulates ABCB1 (zeige ABCB1 ELISA Kits) and ABCG2 drug transporters that are not transporters for cisplatin itself but are transporters for drugs that are frequently used in combination therapy with cisplatin modulating drug response.
Genetic variants of ABCG2, common and rare, increased the risk of gout. Non-synonymous allelic variants of ABCG2 had a significant effect on earlier onset of gout and the presence of a familial gout history.
ABCG2 polymorphisms were not associated with adverse drug reactions to regorafenib treatment.
Inherently high expression of ABCG2 in endocardial endothelial cells protects them against apoptosis in presence of anticancer agents.
ABCG2 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
These findings point to a significant role of the ABCG2 Y581S polymorphism in the milk disposition of enterolactone and the endogenous molecules riboflavin and uric acid, which could affect both milk quality and functionality.
The results suggest that a mutation of SCD1 (zeige SCD ELISA Kits), but not LEPR (zeige LEPR ELISA Kits) or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
P-gp (zeige ABCB4 ELISA Kits), Bcrp and Mrp1 (zeige ABCC1 ELISA Kits) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
This study has, for the first time, confirmed the expression of ABCG2 in epithelial cells of the bovine rumen.
These results contribute to the role of ABCG2 in cytoprotection and disposition in important tissue barriers and may have important implications for veterinary pharmacotherapy of dairy animals.
Generated cell culture model allows rapid and high-throughput screening of potential ruminant ABCG2 substrate, increasing the understanding of carrier-associated secretion of xenobiotics into milk.
Bovine ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the veterinary antibiotic danofloxacin.
ABCG2 plays a role in mammary epithelial cell proliferation, and functional polymorphisms in this gene may influence the cellular compartment of the mammary gland and potentially milk production.
The effect of the Y581S polymorphism of ABCG2 on transcellular transport of veterinary drugs was studied because this could alter substrate pharmacokinetics and milk residues.
Bcrp1 (Abcg2), the murine orthologue of the ABC transporter Breast Cancer Resistance Protein (BCRP, ABCG2), has at least four alternative promoters that are designated by the corresponding four alternative first exons produced: E1U, E1A (zeige BCKDHA ELISA Kits), E1B (zeige BCKDHB ELISA Kits), and E1C. In-silico protocols are presented to predict alternative promoter usage for Bcrp1 (zeige BANF1 ELISA Kits).
Report novel pyrimido[1'',2'':1,5]pyrazolo[3,4-b]quinolones that reverse ABCG2-mediated resistance in cancer cells.
Immunostaining and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1 (zeige SLC2A9 ELISA Kits), ABCG2, and URAT1 (zeige SLC22A12 ELISA Kits). Immunostaining for GLUT9 (zeige SLC2A9 ELISA Kits) was observed in ependymal cells, neurons, and brain capillaries. Immunostaining for ABCG2 was observed in the choroid plexus epithelium and brain capillaries, but not in ependymal cells. These results were validated by in situ hybridization.
[(18)F]Mefway is modulated by P-gp (zeige ABCB4 ELISA Kits), and not by Bcrp in rodents.
P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier
Coadministration of ceritinib with a dual ABCB1 (zeige ABCB1 ELISA Kits) and ABCG2 inhibitor may improve treatment of brain (micro) metastases.
Pparalpha (zeige PPARA ELISA Kits) complex translocates from the cytoplasm into the nucleus and further recruits coactivators and transcription machinery which induce the transcription of Abcg2 gene and ultimately results in upregulation of Bcrp protein expression and function
Among the ABC (zeige ABCB6 ELISA Kits) drug transporters, only ABCG2 was expressed at highly increased levels in a mouse G3 medulloblastoma model.
The studies using Bcrp KO mice serve as an estimation of the clinical plasma concentration-time curve changes in ABCG2 421C>A variants for BCRP substrate drugs with the F ratio correcting the systemic clearance change by Bcrp knockout in Bcrp KO mice.
the renal urate excretion was increased in Abcg2-knockout mice
Functional expression of the ABCG2 efflux transporter in rabbit placenta.
ABCG2-dependent dye exclusion undergoes large expansion in explant culture and becomes associated with high colony formation efficiency.
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
ATP-binding cassette, sub-family G, member 2
, breast cancer resistance protein
, ATP-binding cassette sub-family G member 2
, ATP-binding cassette transporter subfamily G member 2
, ATP-binding cassette, sub-family G (WHITE), member 2
, ATP-binding cassette sub-family G member 2-like
, ABC transporter
, ATP-binding cassette transporter G2
, mitoxantrone resistance-associated protein
, multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2
, placenta specific MDR protein
, placenta-specific ATP-binding cassette transporter
, ATP-binding cassette protein G2
, brain multidrug resistance protein
, ATP binding cassette superfamily G number 2 transporter
, breast cancer resistance protein 1 homolog
, mitoxantrone resistance protein 1
, ATP-binding cassette transporter sub-family G member 2