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study to examine potential associations between a selection of SNPs in the genes encoding TLR2 and TOLLIP (zeige TOLLIP ELISA Kits), and predisposition, severity and outcome of Staphylococcus aureus bloodstream infections (SABSI); the TLR2 and TOLLIP (zeige TOLLIP ELISA Kits) polymorphisms were not associated with susceptibility to SABSI, severity, 30-day all-cause mortality, or SABSI caused by the clonal complex 30 genotype
Biglycan stimulation of endothelial cells increased the interaction between NF-kB and the HIF-1alpha promoter, leading to enhanced promoter activity and increased HIF-1alpha mRNA levels, as well as augmented HIF-1 activity that resulted in VEGF expression
Only the TLR2 +596 SNP was found to be significantly associated to asthma (OR = 3.24 for CT, 2.71 for TT) and particularly to females. The identification of TLR SNPs will reveal potential candidates for gene-environment interactions in Puerto Ricans.
relative frequency of TLR2 polymorphism was similar in heart transplant (HTX (zeige ZIC3 ELISA Kits)) patients and blood donors; TLR2 polymorphism was neither associated with occurrence or level of cytomegalovirus (CMV) infection nor with survival, graft failure or rejection, or CMV serostatus of patient before transplantation
this study shows that neutrophil expression levels of TLR2 are increased in septic patients
in this study using TLR2 and TLR4 (zeige TLR4 ELISA Kits)-reporter cells, lipoproteins were found to inhibit TLR responses with differences in affinity and kinetics
High TLR2 expression is associated with gastric cancer.
Data suggest that anti-inflammatory effects of DHA (and inflammatory effects of palmitic acid) are at least in part mediated through modulating ER homeostasis; ER stress can be differentially modulated by various types of dietary fat; DHA down-regulates ligand-induced activation of TLR2 and TLR4 (zeige TLR4 ELISA Kits) in activated monocytes. (DHA = docosahexaenoic acid; ER = endoplasmic reticulum; TLR = toll (zeige TLR4 ELISA Kits)-like receptor)
these results reveal a novel role of T-cell expressed TLR2 in enhancing the differentiation and function of TH9 T cells
TLR2 plays a key role in platelet hyperreactivity and the prothrombotic state in the setting of hyperlipidemia by sensing a wide range of endogenous lipid peroxidation ligands and activating innate immune signaling cascade in platelets.
we conclude that coordinate engagement of NOD2 (zeige NOD2 ELISA Kits) and TLR2 constitutes a key step in the genesis of Lp-mediated protection from a lethal respiratory virus infection, and represents a critical target for modulation of virus-induced inflammatory pathology.
Toll-like receptor 2 (TLR2) and retinoic acid-inducible gene I (RIG-I (zeige DDX58 ELISA Kits)) cooperatively initiate innate immune responses to MuV infection in mouse ovarian granulosa cells.
This study supports a role for TLR2 and TLR4 (zeige TLR4 ELISA Kits) in periodontal disease and atherosclerosis, corroborating an intricate association between two inflammatory diseases.
Mycobacterium tuberculosis protein Rv3529c suppresses TLR2-mediated proinflammatory responses in macrophages.
Furthermore, it was observed that inflammatory cytokine levels were reduced in TLR2-/- mice after Treg transfer. Thus, these data indicate that TLR2/TLR4 (zeige TLR4 ELISA Kits) regulate F. nucleatum-induced inflammatory cytokines through Tregs in vivo.
During the late stage of middle ear infection, the absence of TLR2 can lead to reduced macrophage recruitment, impaired pneumococcal clearance, and prolonged inflammation. Our results demonstrate that TLR2 signaling is critical for bacterial clearance and timely resolution of inflammation in otitis media induced by pneumococcus.
strains that preferentially activate TLR2, and others that also activate TLR4 (zeige TLR4 ELISA Kits)
a role for TLR2 in controlling cutaneous leishmaniasis disease severity has been demonstrated in vivo; absence of this phenotype in either TLR1 (zeige TLR1 ELISA Kits)-/- or TLR6 (zeige TLR6 ELISA Kits)-/- mice suggests that TLR2 does not have a specific requirement for either known co-receptor during Leishmania infection; findings indicate that parasite lipophosphoglycan is not required for the observed TLR2 mediated effects
results suggest that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle
Transcription levels of TLR2, TLR4 (zeige TLR4 ELISA Kits), and CD14 (zeige CD14 ELISA Kits) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis.
TLR2 and TLR4 (zeige TLR4 ELISA Kits) mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 (zeige TLR4 ELISA Kits) with the formation of NETs and change in surface architecture.
TLR2, TLR1 (zeige TLR1 ELISA Kits), and TLR6 (zeige TLR6 ELISA Kits) haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4 (zeige TLR4 ELISA Kits); granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 (zeige TLR4 ELISA Kits) signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
Whereas previous results regarding the TLR1 (zeige TLR1 ELISA Kits) gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 (zeige TLR4 ELISA Kits) in the ovary.
VB-201 may counter inflammation where TLR-2 and/or CD14 (zeige CD14 ELISA Kits) complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
Toll-like receptor 2 signaling on intestinal epithelial cells may enhance intestinal barrier function and prevent deoxynivalenol-induced barrier dysfunction of epithelial cells.
These results suggest that porcine circovirus 2 induces IL-8 (zeige IL8 ELISA Kits) secretion via the TLR2/MyD88 (zeige MYD88 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits) signalling pathway.
At 14 days after autotransplantation of a pig kidney, mRNA expression for TLR2 is increased.
These data demonstrated that TLR2, TLR3 (zeige TLR3 ELISA Kits) and TLR9 (zeige TLR9 ELISA Kits) contribute to NF-kappaB (zeige NFKB1 ELISA Kits) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (zeige DDX58 ELISA Kits).
Data suggest TLR2, TLR4 (zeige TLR4 ELISA Kits), and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4 (zeige TLR4 ELISA Kits).
TLR2 is required for the suppression of TLR4 (zeige TLR4 ELISA Kits) signaling activation.
The role of TLR2, TLR4 (zeige TLR4 ELISA Kits) and RP105 (zeige CD180 ELISA Kits)/MD1 (zeige LY86 ELISA Kits) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (zeige CLPTM1 ELISA Kits), is reported.
Single nucleotide polymorphisms in TLR2 is associated with immune response to gram-negative bacterial infections.
The dramatic reduction in p38 MAPK (zeige MAPK14 ELISA Kits) phosphorylation by TLR-2 stimulation in aortic valve interstitial cells excludes a role for this receptor type in mediating angiotensin II or peroxynitrite effects.
In total, 20, 27, and 26 SNPs were detected in TLR1 (zeige TLR1 ELISA Kits), TLR2, and TLR6 (zeige TLR6 ELISA Kits), respectively; in TLR1 (zeige TLR1 ELISA Kits) and TLR2, the numbers of SNPs detected were significantly lower (P < or = 0.05, P < or = 0.01) in the wild boars than in the domestic pigs.
expression of TLR4 (zeige TLR4 ELISA Kits) and TLR2 in normal and LPS (zeige IRF6 ELISA Kits)-treated horses
Because factors other than mastitis can affect SCC (zeige CYP11A1 ELISA Kits) and our sample sizes were limited, additional studies are needed to corroborate an association between TLR2 genotype and SCC (zeige CYP11A1 ELISA Kits) or mastitis in goats.
Over-expression of TLR2 decreases radical damage to host cells through low-level production of NO and MDA and promotes the clearance of invasive bacteria by up-regulating lysozyme (zeige LYZ ELISA Kits) secretion and filtration of inflammatory cells to the infected site.
TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection
The results indicate that microglia and astrocytes respond to B (zeige TDO2 ELISA Kits). burgdorferi through TLR1 (zeige TLR1 ELISA Kits)/2 and TLR5 (zeige TLR5 ELISA Kits).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
toll/interleukin 1 receptor-like 4
, toll/interleukin-1 receptor-like protein 4
, toll-like receptor 2 variant 1
, toll-like receptor 2 variant 2
, toll-like receptor 2 type-2
, toll-like receptor 2 type2
, Toll-like receptor 2-like protein