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Fish IRF6 (zeige IRF6 Proteine) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (zeige MYD88 Proteine) and TBK1, suggesting that differences in the IRF6 (zeige IRF6 Proteine) regulation pattern exist between lower and higher vertebrates.
High TBK1 expression is associated with Lung cancer.
Our results highlight an unexpected role of the Golgi apparatus in innate immunity as a key subcellular gateway for TBK1 activation after RNA virus infection.
The results of this study proposed that TBK1 is not a frequent causal gene in Chinese ALS patients.
HERP (zeige HERPUD1 Proteine) Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress
these data suggest that HNSs, an antagonist of host innate immunity, interacts with TBK1 and thereby hinders the association of TBK1 with its substrate IRF3 (zeige IRF3 Proteine), thus blocking IRF3 (zeige IRF3 Proteine) activation and transcriptional induction of the cellular antiviral responses.
Pathogenic variants in TBK1 are rare but could be responsible for sALS (zeige CDH23 Proteine) in a small number of Korean patients.
High TBK1 expression is associated with normal tension glaucoma.
We identified novel genomic TBK1 variants including two loss-of-function (LoF) (p.Leu59Phefs*16 and c.358+5G>A), two missense (p.Asp118Asn and p.Ile397Thr) and one intronic variant (c.1644-5_1644-2delAATA).
Mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrophic lateral sclerosis (ALS (zeige IGFALS Proteine)) with or without comorbid frontotemporal dementia.
The occurrence of TBK1 mutations in FTD (zeige FTL Proteine) and ALS (zeige IGFALS Proteine) underlines the fact that FTD (zeige FTL Proteine) and ALS (zeige IGFALS Proteine) are part of the same disease spectrum. For future therapeutic trials, characterization of TBK1 mutation carriers in presymptomatic cohorts, such as the genetic frontotemporal dementia initiative (GENFI), is of great importance.
these studies reveal an additional regulatory function of TRIM8 (zeige TRIM8 Proteine) in innate immune responses: TRIM8 (zeige TRIM8 Proteine) catalyzes polyubiquitination of TRIF (zeige RNF138 Proteine), resulting in disruption of TRIF (zeige RNF138 Proteine)-TBK1 interaction
TBK1 regulates p16 expression and retinal ganglion cell senescence.
USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome.
The authors report that Raf kinase inhibitory protein (RKIP (zeige PEBP1 Proteine)) is essential for TBK1 activation and type I interferon (zeige IFNA Proteine) production triggered by viral infection.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (zeige FOSL1 Proteine) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (zeige TRAF3 Proteine)), TIR domain-containing adapter inducing IFN-beta (zeige IFNB1 Proteine) (TRIF (zeige RNF138 Proteine)), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 (zeige TRAF3 Proteine) and TRIF (zeige RNF138 Proteine).
TBK1 complexes required for the phosphorylation of IRF3 (zeige IRF3 Proteine) and the production of interferon-beta (zeige IFNB1 Proteine) have been identified.
this study reveals a previously unknown ICOS (zeige ICOS Proteine)-TBK1 signaling pathway that specifies the commitment of germinal center follicular helper T cells
Innate immune responses to adenovirus vectors are largely TBK1-dependent in the spleen but TBK1-independent in the liver
Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (zeige RPS6KB1 Proteine))-STING membrane protein-TANK-binding kinase 1 (TBK1) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (zeige IRF3 Proteine)).
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
serine/threonine-protein kinase TBK1
, TANK-binding kinase 1
, NF-kappa-B-activating kinase
, TANK binding kinase 1
, serine/threonine protein kinase TBK1
, serine/threonine-protein kinase TBK1-like
, NF-kB-activating kinase