anti-TANK-Binding Kinase 1 (TBK1) Antikörper

anti-TANK-Binding Kinase 1 Antikörper (TBK1)
Auf finden Sie aktuell 156 TANK-Binding Kinase 1 (TBK1) Antikörper von 30 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TANK-Binding Kinase 1 Kits (15) und TANK-Binding Kinase 1 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 192 TANK-Binding Kinase 1 Produkte verfügbar.
1200008B05Rik, AI462036, AW048562, NAK, T2K, TBK1, wu:fk70c05, zgc:136548

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Am meisten referenzierte anti-TANK-Binding Kinase 1 Antikörper

  1. Cow (Bovine) Monoclonal TBK1 Primary Antibody für ICC, IF - ABIN252648 : Merimi, Klener, Szynal, Cleuter, Kerkhofs, Burny, Martiat, Van den Broeke: Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code. in Journal of virology 2007 (PubMed)
    Zeige alle 20 Referenzen für 252648

  2. Human Polyclonal TBK1 Primary Antibody für EIA, IHC (p) - ABIN360254 : Deng, Shi, Han, Zhong, Li, Li, Hu, Yan, Wang, He, Tang, Deubel, Luo, Ning, Sun: Negative regulation of virus-triggered IFN-beta signaling pathway by alternative splicing of TBK1. in The Journal of biological chemistry 2008 (PubMed)
    Zeige alle 3 Referenzen für 360254

  3. Human Monoclonal TBK1 Primary Antibody für WB - ABIN967614 : Kishore, Huynh, Mathialagan, Hall, Rouw, Creely, Lange, Caroll, Reitz, Donnelly, Boddupalli, Combs, Kretzmer, Tripp: IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2. in The Journal of biological chemistry 2002 (PubMed)
    Zeige alle 2 Referenzen für 967614

  4. Cow (Bovine) Polyclonal TBK1 Primary Antibody für WB - ABIN2785953 : Morton, Hesson, Peggie, Cohen: Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma. in FEBS letters 2008 (PubMed)

  5. Human Polyclonal TBK1 Primary Antibody für WB - ABIN151881 : Xie, Zhang, Zhao, Lu, You, Condorelli, Wang, Guan: IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)

Weitere Antikörper gegen TANK-Binding Kinase 1 Interaktionspartner

Zebrafish TANK-Binding Kinase 1 (TBK1) Interaktionspartner

  1. Fish IRF6 (zeige IRF6 Antikörper) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (zeige MYD88 Antikörper) and TBK1, suggesting that differences in the IRF6 (zeige IRF6 Antikörper) regulation pattern exist between lower and higher vertebrates.

Human TANK-Binding Kinase 1 (TBK1) Interaktionspartner

  1. High TBK1 expression is associated with normal tension glaucoma.

  2. We identified novel genomic TBK1 variants including two loss-of-function (LoF) (p.Leu59Phefs*16 and c.358+5G>A), two missense (p.Asp118Asn and p.Ile397Thr) and one intronic variant (c.1644-5_1644-2delAATA).

  3. Mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrophic lateral sclerosis (ALS (zeige IGFALS Antikörper)) with or without comorbid frontotemporal dementia.

  4. The occurrence of TBK1 mutations in FTD (zeige FTL Antikörper) and ALS (zeige IGFALS Antikörper) underlines the fact that FTD (zeige FTL Antikörper) and ALS (zeige IGFALS Antikörper) are part of the same disease spectrum. For future therapeutic trials, characterization of TBK1 mutation carriers in presymptomatic cohorts, such as the genetic frontotemporal dementia initiative (GENFI), is of great importance.

  5. demonstrate a key role of TBK1/IKKepsilon (zeige IKBKE Antikörper) in the survival and proliferation of HTLV-1-transformed T cells

  6. Data suggest that Encephalomyocarditis virus 3C protease cleaves TANK and disrupts the TANK-TBK1-IKKepsilon (zeige IKBKE Antikörper)-IRF3 (zeige IRF3 Antikörper) complex, resulting in reduction in IRF3 (zeige IRF3 Antikörper) phosphorylation and type I interferon (zeige IFNA Antikörper) production. (TANK = TRAF family member associated NFKB activator (zeige TANK Antikörper); TBK1 = TANK binding kinase 1; IKKepsilon (zeige IKBKE Antikörper) = inhibitor of nuclear factor kappa B kinase subunit epsilon (zeige IKBKE Antikörper); IRF3 (zeige IRF3 Antikörper) = interferon regulatory factor 3 (zeige IRF3 Antikörper))

  7. Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon (zeige IKBKE Antikörper)) and TANK-binding kinase 1 (TBK1) expression may be involved in the development of intestinal-type gastric cancer.

  8. Here the authors show that recruitment of WIPI2 (zeige WIPI2 Antikörper), itself essential for anti-bacterial autophagy, is dependent on the localization of catalytically active TBK1 to the vicinity of cytosolic bacteria.

  9. review of the role of TBK1 in the seemingly unrelated, yet allelic diseases amyotrophic lateral sclerosis (ALS (zeige IGFALS Antikörper)), frontotemporal dementia (FTD (zeige FTL Antikörper)), normal tension glaucoma (NTG (zeige OPA1 Antikörper)) and childhood herpes simplex encephalitis and discuss the role of TBK1 in neuroinflammatory diseases

  10. Enrichment of qualifying variants toward glaucoma was present in all genes except WDR36 (zeige WDR36 Antikörper), in which controls harbored more variants, and TBK1, in which no qualifying variants were detected in cases or controls.

Mouse (Murine) TANK-Binding Kinase 1 (TBK1) Interaktionspartner

  1. these studies reveal an additional regulatory function of TRIM8 (zeige TRIM8 Antikörper) in innate immune responses: TRIM8 (zeige TRIM8 Antikörper) catalyzes polyubiquitination of TRIF (zeige RNF138 Antikörper), resulting in disruption of TRIF (zeige RNF138 Antikörper)-TBK1 interaction

  2. TBK1 regulates p16 (zeige CDKN2A Antikörper) expression and retinal ganglion cell senescence.

  3. USP38 inhibits type I interferon (zeige IFNA Antikörper) signaling by editing TBK1 ubiquitination through NLRP4 signalosome.

  4. The authors report that Raf kinase inhibitory protein (RKIP (zeige PEBP1 Antikörper)) is essential for TBK1 activation and type I interferon (zeige IFNA Antikörper) production triggered by viral infection.

  5. Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (zeige FOSL1 Antikörper) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (zeige TRAF3 Antikörper)), TIR domain-containing adapter inducing IFN-beta (zeige IFNB1 Antikörper) (TRIF (zeige RNF138 Antikörper)), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 (zeige TRAF3 Antikörper) and TRIF (zeige RNF138 Antikörper).

  6. TBK1 complexes required for the phosphorylation of IRF3 (zeige IRF3 Antikörper) and the production of interferon-beta (zeige IFNB1 Antikörper) have been identified.

  7. this study reveals a previously unknown ICOS (zeige ICOS Antikörper)-TBK1 signaling pathway that specifies the commitment of germinal center follicular helper T cells

  8. Innate immune responses to adenovirus vectors are largely TBK1-dependent in the spleen but TBK1-independent in the liver

  9. Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (zeige RPS6KB1 Antikörper))-STING membrane protein-TANK-binding kinase 1 (TBK1) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (zeige IRF3 Antikörper)).

  10. This study suggest that TBK1 exerts pronociceptive effects in inflammatory nociception which are due to both modulation of NF-kappaB dependent genes and regulation of MAPKs and c-fos.

TANK-Binding Kinase 1 (TBK1) Antigen-Profil

Beschreibung des Gens

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.

Alternative names and synonyms associated with TANK-Binding Kinase 1 (TBK1)

  • TANK-binding kinase 1 (tbk1) Antikörper
  • TANK-binding kinase 1 (TBK1) Antikörper
  • TANK-binding kinase 1 (LOC100358771) Antikörper
  • TANK-binding kinase 1 (Tbk1) Antikörper
  • 1200008B05Rik Antikörper
  • AI462036 Antikörper
  • AW048562 Antikörper
  • NAK Antikörper
  • T2K Antikörper
  • TBK1 Antikörper
  • wu:fk70c05 Antikörper
  • zgc:136548 Antikörper

Bezeichner auf Proteinebene für TBK1

serine/threonine-protein kinase TBK1 , TANK-binding kinase 1 , NF-kappa-B-activating kinase , TANK binding kinase 1 , serine/threonine protein kinase TBK1 , serine/threonine-protein kinase TBK1-like , NF-kB-activating kinase , T2K

446351 Xenopus laevis
452047 Pan troglodytes
692289 Danio rerio
717427 Macaca mulatta
100051650 Equus caballus
100125828 Sus scrofa
100216212 Xenopus (Silurana) tropicalis
100358771 Oryctolagus cuniculus
100399701 Callithrix jacchus
100433568 Pongo abelii
100484104 Ailuropoda melanoleuca
100553575 Anolis carolinensis
100582856 Nomascus leucogenys
29110 Homo sapiens
481145 Canis lupus familiaris
533141 Bos taurus
56480 Mus musculus
299827 Rattus norvegicus
417825 Gallus gallus
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