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anti-Human IRF5 Antikörper:
anti-Mouse (Murine) IRF5 Antikörper:
anti-Rat (Rattus) IRF5 Antikörper:
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Human Polyclonal IRF5 Primary Antibody für ChIP, ELISA - ABIN249633
Barnes, Moore, Pitha: Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. in The Journal of biological chemistry 2001
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Cow (Bovine) Polyclonal IRF5 Primary Antibody für WB - ABIN2779405
Coletta, Cullington, Clark, Cleland: Clinical trials update from European Society of Cardiology meeting 2008: TIME-CHF, BACH, BEAUTIFUL, GISSI-HF, and HOME-HF. in European journal of heart failure 2008
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Mouse (Murine) Polyclonal IRF5 Primary Antibody für WB - ABIN2779987
Takaoka, Yanai, Kondo, Duncan, Negishi, Mizutani, Kano, Honda, Ohba, Mak, Taniguchi: Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. in Nature 2005
Mouse (Murine) Monoclonal IRF5 Primary Antibody für FACS - ABIN4327584
Li, De, Li, Song, Matta, Barnes: Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality. in Scientific reports 2016
Human Monoclonal IRF5 Primary Antibody für IHC (p), IP - ABIN2475143
Barnes, Kellum, Field, Pitha: Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes. in Molecular and cellular biology 2002
Data suggest that IRAK4 (zeige IRAK4 Antikörper) activity regulates activation of IRF5, TAK1 (zeige MAP3K7 Antikörper), and IKKB (zeige IKBKB Antikörper) in monocytes; IRAK4 (zeige IRAK4 Antikörper) activation of TAK1 (zeige MAP3K7 Antikörper)-IKKB (zeige IKBKB Antikörper)-IRF5 axis leads to induction of cytokines and interferons following TLR7 (zeige TLR7 Antikörper)/TLR8 (zeige TLR8 Antikörper) stimulation. (IRAK4 (zeige IRAK4 Antikörper) = interleukin-1 receptor-associated kinase 4 (zeige IRAK4 Antikörper); IRF5 = interferon regulatory factor-5; TAK1 (zeige MAP3K7 Antikörper) = MAPK (zeige MAPK1 Antikörper) kinase kinase 7; IKKB (zeige IKBKB Antikörper) = I-kappa B kinase; TLR = toll (zeige TLR4 Antikörper)-like receptor)
IRF5 and IRF5 disease-risk variants increase glycolysis and human m1 macrophage polarization by regulating proximal signaling and Akt2 (zeige AKT2 Antikörper) activation.
the genomic pattern according to MATH demonstrated that mutation rates of TP53, IRF5 and KRAS were independently associated with MATH, and the latter two were only significant in male patients. As MATH increased, the fraction of somatic copy number alteration (SCNA) elevated. Moreover, more SCNA events was independently associated with MATH in male than in female
IRF-5 targeted the expression of vascular cell adhesion molecule 1 (VCAM-1 (zeige VCAM1 Antikörper)) at the transcriptional level by binding to its promoter.
oncogenic IRF5 overexpression in HL is the result of a specific LTR transcriptional activation
the primary activating regulatory region of human IRF5 was located in its minimal promoter region between nucleotides -179 and +62. In addition, it was shown that Sp1 (zeige PSG1 Antikörper) was able to bind to the multiple sites in IRF5 promoter region, and was involved in the transcriptional regulation of IRF5 at the basal level.
This study demonstrates the association of IRF5 with an increased susceptibility for systemic lupus erythematosus (SLE) in the population of Crete and emphasizes the association of the Neanderthal-derived IRF5 haplotype with SLE susceptibility. Patients carrying allele the Neanderthal allele C had greater type I IFN, supporting a functional consequence of this polymorphism.
this study shows that IRF5 polymorphisms are associated with unexplained recurrent pregnancy loss among Iranian women
The results demonstrated that STAT4 (zeige STAT4 Antikörper) rs7574865 and IRF5 rs2004640G/T substitution are associated with a susceptibility to systemic sclerosis.
Data suggest that interferon beta (IFN-beta (zeige IFNB1 Antikörper)) might be involved in modulating the expressions of interferon regulatory factor 1 (IRF1 (zeige IRF1 Antikörper)) and interferon regulatory factor-5 protein (IRF5) as well as maintaining the M1 polarization status and its function.
BCG (zeige SLC11A1 Antikörper) increased membrane expression of TRIM59 through the TLR2 (zeige TLR2 Antikörper)/ TLR4 (zeige TLR4 Antikörper)/IRF5 pathway in RAW264.7 macrophage cell line.
these results reveal a role for Lyn (zeige LYN Antikörper) as a specific suppressor of the TLR-MyD88 (zeige MYD88 Antikörper)-IRF5 pathway and illustrate the importance of fine-tuning IRF5 activity for the maintenance of immune homeostasis
IRF5 siRNA reverses pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in severe acute pancreatitis associated with acute lung injury.
Our data show that miR (zeige MLXIP Antikörper)-146b targets IRF5, resulting in the regulation of macrophage activation. Furthermore, miR (zeige MLXIP Antikörper)-146b deficient mice developed intestinal inflammation with enhanced M1 macrophage polarization.
data suggest that IRF5 plays a causal role in inflammation, fibrosis and impaired vascular EC function in Tsk (zeige FBN1 Antikörper)/+ mice
study sheds light on the TLR4 (zeige TLR4 Antikörper)-IRF5 pathway in the pathology of SSc (zeige CYP11A1 Antikörper) with clinical implications of targeting the IRF5 pathways in the suppression of disease development
Collectively, these results indicate a key role for IRF-5 in modulating the host antiviral response in peripheral organs that controls bunyavirus neuroinvasion in mice.
studies extend prior ones suggesting that inhibiting IRF5 might be useful for chronic macrophage-induced inflammation and suggest that IRF5 blockade would ameliorate more acute forms of inflammation, including lung injury
IRF5 plays an important role in the development of disease in the MRL/lpr (zeige FAS Antikörper) mouse model of lupus in the absence of the DOCK2 (zeige DOCK2 Antikörper) mutation and that IRF5 is required for the transition from mature B cells to plasma cells.
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
interferon regulatory factor 5
, Interferon regulatory factor 5
, interferon regulatory factor 5-like
, interferon regulatory factor 5 bone marrow