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Human Monoclonal IRF3 Primary Antibody für WB - ABIN967306
Au, Moore, Lowther, Juang, Pitha: Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. in Proceedings of the National Academy of Sciences of the United States of America 1996
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Human Monoclonal IRF3 Primary Antibody für Inhibition, IF - ABIN967285
Darnell, Kerr, Stark: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. in Science (New York, N.Y.) 1994
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Mouse (Murine) Polyclonal IRF3 Primary Antibody für WB - ABIN1881465
Marichal, Bedoret, Mesnil, Pichavant, Goriely, Trottein, Cataldo, Goldman, Lekeux, Bureau, Desmet: Interferon response factor 3 is essential for house dust mite-induced airway allergy. in The Journal of allergy and clinical immunology 2010
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Human Polyclonal IRF3 Primary Antibody für IHC, ELISA - ABIN1002558
Malmgaard: Induction and regulation of IFNs during viral infections. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2004
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Human Polyclonal IRF3 Primary Antibody für ICC, ELISA - ABIN1002559
Fitzgerald, McWhirter, Faia, Rowe, Latz, Golenbock, Coyle, Liao, Maniatis: IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. in Nature immunology 2003
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Human Monoclonal IRF3 Primary Antibody für BR, IF - ABIN2689798
Hiscott, Pitha, Genin, Nguyen, Heylbroeck, Mamane, Algarte, Lin: Triggering the interferon response: the role of IRF-3 transcription factor. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999
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Human Polyclonal IRF3 Primary Antibody für IF (cc), IF (p) - ABIN742688
Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection. in Journal of virology 2013
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Mouse (Murine) Polyclonal IRF3 Primary Antibody für IHC, WB - ABIN3023115
Zhong, Wang, Fang, Zhang, Luo, Shang, Ouyang, Ouyang, Chen, Xiao: Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling. in PLoS ONE 2013
Human Polyclonal IRF3 Primary Antibody für WB - ABIN2668684
Goriely, Molle, Nguyen, Albarani, Haddou, Lin, De Wit, Flamand, Willems, Goldman: Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation. in Blood 2006
Human Monoclonal IRF3 Primary Antibody für IP, ELISA - ABIN2475141
Takahasi, Suzuki, Horiuchi, Mori, Suhara, Okabe, Fukuhara, Terasawa, Akira, Fujita, Inagaki: X-ray crystal structure of IRF-3 and its functional implications. in Nature structural biology 2003
Following spring viremia of carp (zeige ANKRD1 Antikörper) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (zeige ANKRD1 Antikörper) virus. data provide evidence that fish and mammals have evolved a similar IRF (zeige TRIM63 Antikörper)-dependent regulatory mechanism fine-tuning IFN gene activation.
Interferon (zeige IFNA Antikörper) regulatory factor (IRF (zeige TRIM63 Antikörper))10 inhibits the expression of IFN1 and IFN3 to avoid an excessive immune response, a unique regulation mechanism of the IFN responses in lower vertebrates.
Hepatitis A virus protein 2B suppresses beta interferon (zeige IFNA Antikörper) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
MyD88 (zeige MYD88 Antikörper) interacts with interferon (zeige IFNA Antikörper) regulatory factor (IRF) 3 and IRF7 (zeige IRF7 Antikörper) in Atlantic salmon (Salmo salar)
IRF-3 is an important regulator of ORMDL3 (zeige ORMDL3 Antikörper) induction following RSV infection by binding directly to the promoter of ORMDL3 (zeige ORMDL3 Antikörper)
above findings suggest that ATG5-ATG12 positively regulate anti-viral NF-kappaB and IRF3 signaling during FMDV infection, thereby limiting FMDV proliferation. FMDV has evolved mechanisms to counteract the antiviral function of ATG5-ATG12, via degradation of them by viral protein 3C(pro).
NEMO (zeige IKBKG Antikörper)-IKKbeta (zeige IKBKB Antikörper) Are Essential for IRF3 and NF-kappaB (zeige NFKB1 Antikörper) Activation in the cGAS-STING Pathway
these data suggest that HNSs, an antagonist of host innate immunity, interacts with TBK1 (zeige TBK1 Antikörper) and thereby hinders the association of TBK1 (zeige TBK1 Antikörper) with its substrate IRF3, thus blocking IRF3 activation and transcriptional induction of the cellular antiviral responses.
IRF3 is a major transcriptional regulator of adipose inflammation and is involved in maintaining systemic glucose and energy homeostasis
this study shows that IRF-3-mediated apoptosis of virus-infected cells could be an effective antiviral mechanism, without expression of the interferon (zeige IFNA Antikörper)-stimulated genes
Data in this study show that cFLIPL inhibits IFN regulatory factor 3 (IRF3), a transcription factor central for IFN-beta (zeige IFNB1 Antikörper) and IFN-stimulated gene expression.
1,8-cineole potentiates the antiviral activity of IRF3 in addition to its inhibitory effect on proinflammatory NF-kappaB (zeige NFKB1 Antikörper) signaling in an ex vivo model of rhinosinusitis.
TBK1 (zeige TBK1 Antikörper) complexes required for the phosphorylation of IRF3 and the production of interferon-beta (zeige IFNB1 Antikörper) have been identified.
RIG-I (zeige DDX58 Antikörper)-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway
The authors used recombinant classical swine fever virus N(pro) and swine IRF3 proteins and show that N(pro) interacts with IRF3 directly without additional proteins and forms a soluble 1:1 complex.
Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 and subsequent degradation of IRF-3, leading to downregulation of IFN-alpha (zeige IFNA Antikörper)/beta production.
The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta (zeige IFNB1 Antikörper) promoter activity in MARC (zeige CCL7 Antikörper)-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3.
proteasomal degradation of IRF3 is induced by a direct or indirect interaction with N(pro).
This study did not find non-conservative mutations among SJL, B10.S, B6 and B10 mice in the IRF3 amino acid sequence, and show SJL bone marrow-derived macrophages infected with Theiler's murine encephalomyelitis virus exhibit increased virus RNA replication and infectious virus yields as well as greater IL-6 production than C57Bl strain (including B10.S) cultures.
The IRF-3 pathway is essential for tick-borne encephalitis virus-induced RANTES (zeige CCL5 Antikörper) production in the brain.
Yersinia YopJ negatively regulates IRF3-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.
Findings indicate that STING-TBK1 (zeige TBK1 Antikörper)-IRF3 pathway mediates a crosstalk between ER stress and apoptosis during M. bovis infection, which can effectively control intracellular bacteria.
GPR146 has an antiviral role in fighting against viral infection, although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling.
Results establish Irf3, known mostly for its role in antiviral responses, as a transcription factor involved in the induction of Th2 responses through the promotion of pro-Th2 costimulation in CD11b (zeige ITGAM Antikörper)(+) dendritic cells
Rubicon (zeige KIAA0226 Antikörper) specifically interacts with the interferon (zeige IFNA Antikörper) regulatory factor (IRF (zeige TRIM63 Antikörper)) association domain (IAD) of IRF3, and this interaction leads to inhibition of the dimerization of IRF3, which negatively regulates interferon (zeige IFNA Antikörper)-mediated antiviral response.
The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta (zeige IFNB1 Antikörper) promoter activity and induces IRF3 degradation.
cpBVDV infection causes a marked loss of interferon regulatory factor 3 (IRF-3), a cellular transcription factor that controls interferon (zeige IFNA Antikörper) synthesis.
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
interferon regulatory factor 3
, interferon regulatory factor 3-like