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Human CD36 Protein expressed in Human Cells - ABIN2003345
Xu, Efremov, Li, Lai, Dao, Lim, Cao: Probing the cytoadherence of malaria infected red blood cells under flow. in PLoS ONE 2013
Nonclassical monocytes crawl/patrol along the vessel wall during early atherogenesis via CD36 signaling.
In conclusion, we demonstrated in this study for the first time that periodontal CD36 expression was associated with MetS-exacerbated periodontitis. We also demonstrated that CD36 is involved in the enhancement by palmitate of LPS (zeige TLR4 Proteine)-induced inflammatory molecule expression in macrophages.
Results show that CD36 and Platelet-Activating Factor Receptor (zeige PTAFR Proteine) are important mediators of house dust mites (HDM (zeige HDAC3 Proteine)) allergy development and that inhibiting HDM (zeige HDAC3 Proteine) engagement with phosphorylcholine receptors in the lung protects against allergic airway disease.
Our results suggest that LPA-enhanced foam cell formation is mediated by LPA1 (zeige LPAR1 Proteine)/3 -AKT (zeige AKT1 Proteine) activation and subsequent SRBI (zeige SCARB1 Proteine) expression.
These findings suggest that atherogenic conditions critically regulate platelet CD36 signaling by increasing superoxide radical anion and hydrogen peroxide through a mechanism that promotes activation of MAPK (zeige MAPK1 Proteine) ERK5 (zeige MAPK7 Proteine).
the results obtained from Ccr2 (zeige CCR2 Proteine)(-/-), Cd36(-/-), and CD36 bone marrow chimeric mice showed that sequestration in the absence of CD36-mediated phagocytic clearance by monocytes leads to exaggerated lung pathologic features.
In addition, purinergic receptor P2X, ligand-gated ion channel 7 (P2X7 (zeige P2RX7 Proteine)) was downregulated in CD36-knockdown 3T3-L1 cells, suggesting that the suppression of CD36 attenuates adipogenesis via the P2X7 (zeige P2RX7 Proteine) pathway in 3T3-L1 cells.
Data suggest that the transmembrane domains of Tlr4 (zeige TLR4 Proteine) and Tlr6 (zeige TLR6 Proteine) have essential roles in Tlr4 (zeige TLR4 Proteine)/Tlr6 (zeige TLR6 Proteine)/Cd36 receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 (zeige TLR4 Proteine) transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death.
Results show the first high-resolution structure of the C-terminal transmembrane domain of SR-BI (zeige SCARB1 Proteine). This region of SR-BI (zeige SCARB1 Proteine) harbors a leucine zipper dimerization motif, which when mutated impairs the ability of the receptor to bind HDL (zeige HSD11B1 Proteine) and mediate cholesterol delivery.
The A allele of the rs1761667 single nucleotide polymorphism in CD36 is associated with decreased fat and sugar intake in obese children and adolescents.
The present study concluded that miR (zeige MLXIP Proteine)-758-5p decreases lipid accumulation of foam cell via regulating CD36-mediated cholesterol uptake.
Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B (zeige IL1B Proteine) rs16944, IL1R2 (zeige IL1R2 Proteine) rs2071008, PLA2G7 (zeige Lp-PLA2 Proteine) rs9395208, FAM5C rs12732361, CD40 (zeige CD40 Proteine) rs1800686, and CD36 rs2065666 were associated with coronary heart disease (CHD (zeige CHDH Proteine)), suggesting an important role of inflammation in the risk of CHD (zeige CHDH Proteine).
CD36 single nucleotide polymorphisms rs1194182 and rs10499859 reduce risk to pulmonary tuberculosis in a Chinese Han population.
CD36 and MARCO are associated with the susceptibility of Chinese Han females to carotid atherosclerosis. Menopausal status may affect the association between gene polymorphisms and carotid atherosclerosis in the female Chinese Han population.
this study shows that diet-induced obesity links to estrogen receptor (zeige ESR1 Proteine)-positive breast cancer progression via LPA (zeige APOA Proteine)/PKD-1 (zeige PKD1 Proteine)-CD36 signaling-mediated microvascular remodeling
High CD36 expression is associated with Acute Monocytic Leukemia (zeige KAT6B Proteine).
Common CD36 SNPs reduce adipose and heart CD36 levels to higher chylomicron remnants and LDL in humans.
Cardiotonic steroids activate NF-kappaB (zeige NFKB1 Proteine) leading to proinflammatory cytokine production in primary macrophages through a signaling complex, including CD36, TLR4 (zeige TLR4 Proteine), and Na/K-ATPase (zeige ATP1A1 Proteine).
These results suggest that increased expression of hepatic CD36 and SREBP-1 (zeige SREBF1 Proteine) is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Gammadelta T cells express CD36 and it contributes to responses by these cells to microbial lipoteichoic acid.
Niacin Reduces serum level and adipose mRNA expression of leptin (zeige LEP Proteine) and up-regulates PPARgamma (zeige PPARG Proteine) and CD36 mRNA expression in hypercholesterolemic rabbits.
Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47 (zeige CD47 Proteine)-dependent manner
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
, enkephalin convertase
, prohormone-processing carboxypeptidase
, PAS IV
, fatty acid translocase
, glycoprotein IIIb
, platelet glycoprotein 4
, platelet glycoprotein IV
, CD36 antigen (collagen type I receptor, thrombospondin receptor)
, PAS-4 protein
, cluster determinant 36
, leukocyte differentiation antigen CD36
, scavenger receptor class B, member 3
, CD36 antigen like
, CD36 antigen
, adipocyte membrane protein
, collagen type I receptor thrombospondin receptor
, fatty acid transport protein
, fatty acid translocase/CD36
, collagen type I receptor, thrombospondin receptor
, FAT tumor suppressor homolog 1
, cadherin FAT1 isoform +12
, protocadherin Fat 1
, FAT tumor suppressor homolog 1 (Drosophila)
, HDL QTL 1
, scavenger receptor class B member 1
, scavenger receptor class B type I
, scavenger receptor class B1