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Human CD14 Protein expressed in Wheat germ - ABIN1348531
Gu, Werner, Bergmann, Whitcomb, Büchler, Fortunato: Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis. in Cell death & disease 2013
Data show that multiple phagocytes are capable of hyperactivation in response to oxPAPC, with CD14 antigen acting as the earliest regulator in this process, serving to capture and transport these lipids to promote inflammatory cell fate decisions.
Data (including data from studies conducted in cells from knockout mice) suggest that signaling via Lpar1 (zeige LPAR1 Proteine), Cd14, and Scara1 (zeige MSR1 Proteine) mediates uptake of oxidized LDL by macrophages leading to foam cell formation; lysophosphatidic acid (LPA) induces expression of Cd14 and Scara1 (zeige MSR1 Proteine) in macrophages. (Lpar1 (zeige LPAR1 Proteine) = LPA receptor 1 (zeige LPAR1 Proteine); Cd14 = monocyte differentiation antigen CD14; Scara1 (zeige MSR1 Proteine) = scavenger receptor class A type I)
Stimul (zeige TLR4 Proteine)ation of murine peritoneal macrophages with LPS indu (zeige TLR4 Proteine)ces biphasic accumulation of PI(4,5)P2 with peaks at 10 and 60-90 min that was abrogated when C (zeige TLR4 Proteine)D14 was removed from the cell surface.
these results indicate that CD14 is a co-receptor of TLR4 (zeige TLR4 Proteine) in the S100A9 (zeige S100A9 Proteine)-induced cytokine response.
this study shows that lipid rafts may serve as sites in which LPS (zeige TLR4 Proteine) receptors (CD14) are sorted for endocytosis, rather than being platforms for the assembly of TLR4 (zeige TLR4 Proteine)-centered signaling complexes
These findings suggested that the degree of lung injury was reduced during the acute inflammatory reaction when NFkappaB was inhibited, and that the expression of sphingomyelin synthase 2 (zeige SGMS2 Proteine) may affect the induction of the NFkappaB pathway by lipopolysaccharide through CD14.
Results demonstrate remarkable sophistication of microglial CD14 in enabling, facilitating and moderating innate immune responses to infectious and non-infectious CNS threats of diverse kinds
CD14-mediated lipid signaling induced epithelial apoptosis, whereas TLR4 (zeige TLR4 Proteine) antagonistically promoted cell survival and cancer development.
fucosyllactose directly inhibits lipopolysaccharide-mediated inflammation during E. coli infection of intestinal epithelial cells through attenuation of CD14 induction.
studies revealed a novel physical association between SP-R210S, CD14, and SR-A (zeige MSR1 Proteine) leading to an enhanced response to LPS (zeige TLR4 Proteine), and found that SP-R210L and SP-R210S regulate internalization of CD14 via distinct macropinocytosis-like mechanisms
Anti-apoA-1 IgG are independent predictors of nonfatal incident coronary artery disease in the general population. The strength of this association is dependent on a functional polymorphism of the CD14 receptor gene, a finding suggesting a gene-autoantibody interaction for the development of CAD.
CD14 (zeige NDUFA2 Proteine) haplotypes and sCD14 are important mediators of lung function among those with COPD (zeige ARCN1 Proteine) in this occupationally-exposed population.
IL-1beta (zeige IL1B Proteine)-primed dendritic cells express high levels of CD14 (zeige NDUFA2 Proteine) that mediate IL-17 (zeige IL17A Proteine) production through direct interaction with T cells.
The distribution of the CD14 rs2569190 genotypes and allele frequencies showed significant differences between the test and control groups. Prevalence of the polymorphic TT genotype and T allele of the CD14 rs2569190 were significantly increased in GCP patients when compared with healthy controls
Neovascularized atherosclerotic lesions selectively associate with lower blood levels of CD14 (zeige NDUFA2 Proteine)+ and CD14 (zeige NDUFA2 Proteine)(high)CD16 (zeige CD16 Proteine)- monocytes independently of systemic inflammatory activity.
CXCR7 (zeige CXCR7 Proteine) mediates CD14 (zeige NDUFA2 Proteine)(+)CD16 (zeige CD16 Proteine)(+) monocyte transmigration across the blood brain barrier, and is a potential therapeutic target for neuro AIDS.
META-ANALYSIS: association between the -159C/T polymorphism in the promoter region of the CD14 (zeige NDUFA2 Proteine) gene and sepsis
In LPS (zeige IRF6 Proteine)-stimulated HEK293 cells with low CD14 (zeige NDUFA2 Proteine) and high TLR4 (zeige TLR4 Proteine), no accumulation of PI(4,5)P2 occurred. With an increasing amount of CD14 (zeige NDUFA2 Proteine) and decrease of TLR4 (zeige TLR4 Proteine), 2 peaks of PI(4,5)P2 appeared, approaching those found in LPS (zeige IRF6 Proteine)-stimulated cells expressing CD14 (zeige NDUFA2 Proteine) alone. This suggests that LPS (zeige IRF6 Proteine)-induced accumulation of PI(4,5)P2 that maximizes TLR4 (zeige TLR4 Proteine) signaling is controlled by CD14 (zeige NDUFA2 Proteine), whereas TLR4 (zeige TLR4 Proteine) can fine tune this via PI(4,5)P2 turnover.
Intermediate CD14 (zeige NDUFA2 Proteine)++CD16 (zeige CD16 Proteine)+monocytes might be closely related to the pathogenesis of atrial fibrillation and reflect functional remodelling of the left atrium.
In 121 primary sclerosing cholangitis patients, the CD14 (zeige NDUFA2 Proteine) -260C>T genotype was associated with development of dominant bile duct strictures (P = 0.02). In 365 liver transplantation patients, TT carriers (4.1%) were protected against the formation of nonanastomotic biliary strictures versus CC/CT patients (12.6%; P = 0.01).
Transcription levels of TLR2, TLR4 (zeige TLR4 Proteine), and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Data from an in vitro co-culture model suggest that an early response of endometrium in uterine infection is up-regulation of expression of CD14 and TLR4 (toll-like receptor 4 (zeige TLR4 Proteine)).
This study study confirmed that expression of CD14 in blood polymorpnuclear cells (PMN (zeige TBCE Proteine)), resident PMN (zeige TBCE Proteine) and inflammatory PMN (zeige TBCE Proteine) from heifer mammary glands was accompanied by apoptosis and necrosis.
data are consistent with a role for lipopolysaccharide binding protein (zeige LBP Proteine) and soluble CD14 antigen molecules in mediating mammary gland responses to lipopolysaccharide(lipopolysaccharide binding protein- LBP (zeige LBP Proteine))
Toll-like receptor 4 (zeige TLR4 Proteine) mRNA and CD14 mRNA and protein were detected in bovine endometrial stromal and epithelial cells by RT-PCR and flow cytometry.
SNP and association analyses have provided baseline information that may be used at defining the role of CD14 in mediating bacterial infections
VB-201 may counter inflammation where TLR-2 and/or CD14 complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
Determine native soluble CD14 concentrations in serum from healthy and septic foals, in the colostrum of healthy mares and in plasma from adult horses with recurrent airway obstruction and control horses.
CD14 mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein.
monocyte differentiation antigen CD14
, myeloid cell-specific leucine-rich glycoprotein
, CD14 antigen
, lipopolysaccharide receptor