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Human Thyroperoxidase Protein expressed in Escherichia coli (E. coli) - ABIN413833
Kinzfogl, Hangoc, Broxmeyer: Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. in Blood 2011
The results of the study suggest that rs11675434 SNP located near TPO (zeige THPO Proteine) is associated with the development of Graves ophthalmopathy, especially in males and patients with later age of the disease onset.
Mutations in the TPO (zeige THPO Proteine) gene are associated with Congenital hypothyroidism and thyroid dyshormonogenesis.
Compound heterozygous mutations in the TPO (zeige THPO Proteine) gene are associated with congenital hypothyroidism.
Mutations in the genes for thyroglobulin (zeige TG Proteine) and thyroid peroxidase cause thyroid dyshormonogenesis and autosomal-recessive intellectual disability
Studies suggest that Thyroid Peroxidase autoantibodies in early to mid-pregnancy is associated with concurrent depression and may be predictive of depression in the postpartum period.
Anti-thyroid peroxidase (TPO) antibodies and male gender were significantly associated with glucose impairment in patients with beta thalassemia major.
Lower pretreatment serum CXCL10 (zeige CXCL10 Proteine) levels are associated with thyroid dysfunction. Thyroid dysfunction prevalence increases in female patients and patients who are positive for TPOAb at baseline.
Two novel inactivating mutations (c.1970T> C and c.2665G> T) in the TPO (zeige THPO Proteine) gene cause congenital hypothyroidism.
function and autoantigenicity of TPO (zeige THPO Proteine)
This study confirms the pathogenicity of Y55X mutation in two patients with congenital hypothyroidism and demonstrates that a nonsense mutation in the amino-terminal coding region of the TPO (zeige THPO Proteine) gene could totally abolish the function of the TPO (zeige THPO Proteine) enzyme leading to total iodide organification defect.
Hearing impairment in hypothyroid dwarf (zeige POU1F1 Proteine) mice caused by mutations of the thyroid peroxidase gene.
Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO (zeige THPO Proteine).
A novel hypothyroid dwarfism is due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.
TPO gene was mapped
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
, thyroid peroxidase-like
, thyroid microsomal antigen
, thyroid peroxidase (332 AA)