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Lee, Kumar, Rani, Foster: Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats. in Neurobiology of aging 2014
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Horta, Braga, Lemos-Filho, Modolo: Organ-coordinated response of early post-germination mahogany seedlings to drought. in Tree physiology 2014
Overexpression of mitochondrial TXNRD2 (zeige TXNRD2 ELISA Kits) in Drosophila melanogaster extended median lifespan in female flies with a small lifespan extension in males; in contrast, overexpression of the cytosolic form, TXNRD1 (zeige TXNRD1 ELISA Kits), did not produce a lifespan extension.
Molecular orbital calculations suggested that the C-terminal hexapeptide Pro-Ala-Ser (zeige SIGLEC1 ELISA Kits)-Cys-Cys (zeige DNAJC5 ELISA Kits)-Ser (zeige SIGLEC1 ELISA Kits)-OH functions as a redox center that alleviates the necessity for selenium in Dm-TrxR.
analysis of the mechanism of high Mr thioredoxin reductase from Drosophila melanogaster
changing of His106 to asparagine, glutamine, and phenylalanine in various C-terminal mutants of Drosophila melanogaster thioredoxin reductase drops catalytic activity without change in pH profile
X-ray crystal structure of thioredoxin reductase at 2.4 A resolution; demonstrated that tetrapeptides equivalent to the oxidized C-terminal active sites of both mouse mitochondrial TR (mTR3 (zeige EXOSC6 ELISA Kits)) and DmTR are substrates for the truncated forms of both enzymes
redox potentials provide direct evidence for proposed catalytic mechanism of DmTrxR, & cast new light on essential role of DmTrx system in cycling GSSG/GSH & maintaining intracellular redox homeostasis in D. melanogaster without glutathione reductase.
rates of steps in both the reductive and the oxidative half-reactions are markedly diminished in H464'Q thioredoxin reductase as compared to those of wild-type enzyme, indicating that His-464' is involved in both half-reactions
the role of Glu (zeige SLC2A1 ELISA Kits)-469' in catalysis by DmTrxR
Data indicate that glutathione reductase 2 (GR2) protects photosystem II (PSII) from excess light and maintains the function of acceptor side of PSII.
Plastid-localized glutathione reductase-2-regulated glutathione redox status is essential for Arabidopsis root apical meristem maintenance.
GSR expression was higher in TMZ-resistant cells than in sensitive cells. GSR silencing in drug-resistant cells improved the sensitivity of cells to TMZ or cisplatin. Over-expression resulted in resistance. GSR partially prevented the oxidative stress caused by L-buthionine -sulfoximine. The action of GSR in drug resistance is associated with the modulation of redox homeostasis. High GSR correlated with lower survival.
Plasma glutathione reductase (GR) activity was correlated with erythrocyte GR activity and the erythrocyte reduced glutathione/glutathione disulfide ratio. A decrease in plasma GR activity was associated with an increase in mortality in septic shock.
Glutathione reductase reduces mitochondrial protein (zeige COX6B2 ELISA Kits) mitoNEET (zeige CISD1 ELISA Kits) [2Fe-2S] clusters.
The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR and AA rs3763511of gene DKK4 (zeige DKK4 ELISA Kits).
GSR was the most significant single SNP association with systemic lupus erythematosus in African Americans.
1,25 (OH) vitamin D significantly upregulated expression of GCLC (zeige GCLC ELISA Kits) and GR and lowered secretion of IL-8 (zeige IL8 ELISA Kits) and MCP-1 (zeige CCL2 ELISA Kits) in high-glucose exposed U937 monocytes.
The results demonstrate for the first time that glutathione reductase gene polymorphisms are significantly associated with bone mineral density.
Up-regulation of CAT and GR activity resulted in an increase in total antioxidant activity in A549 after exposure to B (zeige TDO2 ELISA Kits)(a)P.
Human eye lenses were dissected into discrete regions that were formed at different stages of life and assayed for activity of lactate dehydrogenase (LDH) and a particularly stable enzyme, glutathione reductase (GR).
novel glutathione reductase alternative splice variants
GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea; the thioredoxin/thioredoxin (zeige TXN ELISA Kits) reductase (zeige PRDX2 ELISA Kits) system can probably operate as a functional backup for GSR.
Data show that reducing RGS2 (zeige RGS2 ELISA Kits) expression by antisense treatment prevented the increase in GLO1 (zeige GLO1 ELISA Kits) and GSR1 mRNA and protein expression.
Local overexpression in the mouse brain resulted in increased anxiety-like behaviour; Gsr is involved in oxidative stress metabolism, linking this pathway with anxiety-related behaviour
Liver biopsy is a valuable tool for detecting oxidative stress and for diagnosing hepatic dysfunction in cattle from glutathione and glutathione reductase levels.
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
glutathione reductase, gro-2
, glutathione reductase
, glutathione reductase, mitochondrial
, glutathione-disulfide reductase
, Glutathione reductase (GR) (GRase)
, disulfide reductase
, thioredoxin reductase
, thioredoxin reductase-1
, glutathione reductase 1