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anti-Human TERT Antikörper:
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Human Monoclonal TERT Primary Antibody für ICC, FACS - ABIN151783
Masutomi, Yu, Khurts, Ben-Porath, Currier, Metz, Brooks, Kaneko, Murakami, DeCaprio, Weinberg, Stewart, Hahn: Telomerase maintains telomere structure in normal human cells. in Cell 2003
Show all 15 Pubmed References
Human Monoclonal TERT Primary Antibody für FACS, ICC - ABIN151763
Zhang, Eguchi, Kruse, Gomez, Fakhrai, Schroter, Ma, Hoa, Minev, Delgado, Wepsic, Okada, Jadus: Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Show all 10 Pubmed References
Dog (Canine) Polyclonal TERT Primary Antibody für ICC, IF - ABIN265626
Walshe, Harkin: Serial explant culture provides novel insights into the potential location and phenotype of corneal endothelial progenitor cells. in Experimental eye research 2014
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Human Polyclonal TERT Primary Antibody für IF (cc), IF (p) - ABIN686167
Gao, Zhao, Song, Yang: Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs. in Molecular biology reports 2012
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Mouse (Murine) Polyclonal TERT Primary Antibody für WB - ABIN3043095
Qiu, Li, Sui, Sun, Huang, Si, Ge: Immunization with truncated sequence of Telomerase Reverse Transcriptase induces a specific antitumor response in vivo. in Acta oncologica (Stockholm, Sweden) 2007
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Human Polyclonal TERT Primary Antibody für DB, IF - ABIN390002
Radan, Hughes, Teichroeb, Vieira Zamora, Jewer, Postovit, Betts: Microenvironmental regulation of telomerase isoforms in human embryonic stem cells. in Stem cells and development 2014
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Human Polyclonal TERT Primary Antibody für FACS, IF - ABIN388165
Sekaric, Cherry, Androphy: Binding of human papillomavirus type 16 E6 to E6AP is not required for activation of hTERT. in Journal of virology 2007
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The presence of TERT promoter mutations was not associated with clinico-pathological variables. Taken together, the germline TERT genetic background may significantly affect the onset of TERT promoter mutations in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper))s, which provides a better understanding of HCC (zeige FAM126A Antikörper)-related TERT promoter mutations and telomerase regulation in cancer.
TERT translocations, copy gains, missense and promoter mutations were identified in 41% of acral melanoma patients. TERT inhibition has cytotoxic effects on primary melanoma cells.
Germline mutations in TERT (rs2736100, n = 33) and CDKN1A (rs2395655, n = 27) associated with idiopathic pulmonary fibrosis risk were detected in most samples.
NSCLC patients with higher expression level of TERT mRNA in lung tumor tissues had a longer MST (zeige MAP3K10 Antikörper) and decreased death risk than those with low expression level of TERT mRNA
TERT promoter mutations in solitary fibrous tumor influence gene expression and are associated with adverse patient outcome
Review of research progress of TERT-mediated and ATRX (zeige ATRX Antikörper)-mediated telomere maintenance and neuroblastoma (zeige ARHGEF16 Antikörper), especially high-risk tumors
GRIM-19 (zeige NDUFA13 Antikörper) expression in cervical cancer cells could inhibit telomerase activity by inhibiting the transactivation of the hTERT promoter by E6, thereby promoting cervical cancer cell senescence.
The presence of TERT promoter mutations is independently associated with increased mortality in patients with differentiated thyroid cancer. The results suggest that inclusion of TERT promoter mutation analysis with conventional clinicopathological evaluation can lead to better prognostication and management for individual patients.
the role of altered TERT activity in the manifestation of autism spectrum disorder, is reported.
Variability in placental telomere length is associated with alterations in DNAm at TERT, DNMT1 (zeige DNMT1 Antikörper), and DNMT3a (zeige DNMT3A Antikörper).
The results establish that null mutation in trt-1 improves survival and attenuates damage to the DAergic system.
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase-deficient zebrafish show p53 (zeige TP53 Antikörper)-dependent premature aging and reduced lifespan in the first generation.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomere shortening is more rapid in fas (zeige FASN Antikörper) tert double mutants than in fas1 (zeige FAS Antikörper), fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 (zeige POT1 Antikörper) protein, POT1A (zeige POT1 Antikörper) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (zeige DKC1 Antikörper) associates with active telomerase RNP (zeige RNPC3 Antikörper) particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
Reactivation of Tert in the hippocampus was sufficient to normalize the depressive but not the aggressive behaviors of Tert(-/-) mice. Conversely, re-expression of Tert in the medial prefrontal cortex (mPFC) reversed the aggressive but not the depressive behavior of Tert(-/-) mice.
Nrf2 (zeige NFE2L2 Antikörper)-driven TERT regulates pentose phosphate pathway in glioblastoma.
TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 (zeige E2F1 Antikörper) target gene expression in smooth muscle cells.
these findings support a model in which gain of TERT function modulates mTORC1 activity and induces autophagy.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (zeige MYC Antikörper), Cyc (zeige CYCS Antikörper)-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment
Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress
Wnt10a (zeige WNT10A Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
This study reports the characterisation of two novel mouse TERT splice variants, Ins (zeige INS Antikörper)-i1[1-102] (Insi1 for short) and Del-e12 (zeige ELSPBP1 Antikörper)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.
TERT may promote gastric cancer metastasis through the TERT-miR (zeige MLXIP Antikörper)-29a-ITGB1 (zeige ITGB1 Antikörper) regulatory pathway.
TERT switches macrophages towards M1 phenotype by regulating NF-kappaB (zeige NFKB1 Antikörper) signaling, but has limited effect on M2 macrophages polarization in vitro.
TERT serves an essential role in formation of the anterior-posterior axis in Xenopus laevis embryos; role for telomerase as a transcriptional modulator of the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signalling pathway
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
telomerase catalytic subunit
, telomerase-associated protein 2
, Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, telomerase reverse transcriptase beta
, Telomerase catalytic subunit