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RFC1 plays critical roles in abscisic acid-mediated homologous recombination in Arabidopsis.
That RFC1 is found in divergent eukaryotes suggests a previously unrecognized and highly conserved role for DNA synthesis in discriminating between recombination pathways.
results suggest that RFC1 helps mediate genomic stability and transcriptional gene silencing in Arabidopsis thaliana
Dada (zeige ADA Antikörper) suggest that AtRFC1 plays an important role in embryo development in Arabidopsis thaliana.
The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 were not detected in 2-cel embryos and blastocysts.
Interleukin-6 (zeige IL6 Antikörper) regulated the efficacy of methotrexate by decreasing the expression of SLC19A1 (zeige SLC19A1 Antikörper).
First evidence of RFC (zeige SLC19A1 Antikörper) expression in rapidly dividing cells of developing neural tube, craniofacial region, limb buds and heart duggests that these regions may be particularly susceptible to folate deficiency.
Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin (zeige CUBN Antikörper)-amnionless (zeige AMN Antikörper)-megalin (zeige LRP2 Antikörper) complex that are involved in the maternal-fetal transport of folate and other nutrients.
Intestinal folate uptake process undergoes differentiation-dependent regulation and that this regulation is mediated via changes in the level of expression of both the RFC (zeige SLC19A1 Antikörper) and PCFT (zeige SLC46A1 Antikörper).
Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp.
this meta-analysis shows that RFC1 gene polymorphism is associated with responsiveness to methotrexate therapy, but may not be associated with methotrexate toxicity in rheumatoid arthritis patients
RFC-1 80G > A gene polymorphism is not associated with methotrexate treatment response in South Indian Tamils with rheumatoid arthritis
The MTHFR (zeige MTHFR Antikörper) 677CC and GGH (zeige GGH Antikörper) 401TT and CT genotypes were associated with a reduction in the number of MTX (zeige MTX1 Antikörper)-related adverse events
We conclude that bearing allele G of rs1051266 polymorphism in RFC1 may contribute to increased efficacy of MTX (zeige MTX1 Antikörper) treatment and may contribute to improved outcome in osteosarcoma patients
We found that the compound mutation genotypes MTHFD (zeige MTHFD1 Antikörper)-G1958A, MTR (zeige MTR Antikörper)-A2756G, and RFC1-G80A increased the risk of preterm birth (OR = 2.88, 95%CI = 1.08-7.72, P = 0.028).
3 biallelic polymorphic variants (rs1051266, rs4818789 and rs3788205) were selected. Results provided support suggesting role of RFC1 in NSCL (zeige NHLH1 Antikörper)/P etiology, reinforcing idea genetic predisposition to NSCL (zeige NHLH1 Antikörper)/P varies in different ethnic groups.
this is the first study to simultaneously evaluate both DNA methylation (zeige HELLS Antikörper) and protein expression of all three folate transporter genes, FOLR1 (zeige FOLR1 Antikörper), PCFT (zeige SLC46A1 Antikörper), and RFC1, in colorectal cancer.
The frequency of RFC-1 rs1051266 (G80A) was 58.4% and 57.1% in children with nephroblastoma and neuroblastoma (zeige ARHGEF16 Antikörper), respectively. Mother and child G80A genotypes play a role in the risk of neuroblastoma (zeige ARHGEF16 Antikörper) and nephroblastoma.
RFC depletion had a negative impact on LANA's ability to replicate and maintain viral DNA in cells containing artificial KSHV episomes or in infected cells, leading to loss of virus.
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
A1 140 kDa subunit
, ISRE-binding protein
, RF-C 140 kDa subunit
, activator 1 140 kDa subunit
, activator 1 large subunit
, activator 1 subunit 1
, differentiation-specific element-binding protein
, replication factor C 1
, replication factor C 140 kDa subunit
, replication factor C large subunit
, replication factor C subunit 1
, replication factor C, 140 kDa
, DNA-binding protein PO-GA
, MHC binding factor, beta
, replication factor C1
, folate transporter 1
, intestinal folate carrier 1
, intestinal folate carrier protein
, reduced folate carrier 1
, solute carrier family 19 (sodium/hydrogen exchanger), member 1
, solute carrier family 19 member 1
, methotrexate carrier 1
, methotrexate carrier 2
, methotrexate carrier 5
, methotrexate carrier 6
, solute carrier family 19, member 1