anti-ACD (ACD) Antikörper

Bezeichnung:
anti-Adrenocortical Dysplasia Homolog (Mouse) Antikörper (ACD)
Auf www.antikoerper-online.de finden Sie aktuell 80 Adrenocortical Dysplasia Homolog (Mouse) (ACD) Antikörper von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ACD Kits (17) und ACD Proteine (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 115 ACD Produkte verfügbar.
Synonyme:
ACD, PIP1, PTOP, TINT1, TPP1

Meistgesuchte Reaktivitäten zu anti-ACD (ACD) Antikörper

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anti-Human ACD Antikörper:

anti-Rat (Rattus) ACD Antikörper:

anti-Mouse (Murine) ACD Antikörper:

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Am meisten referenzierte anti-ACD Antikörper

  1. Human Monoclonal ACD Primary Antibody für IF, WB - ABIN395038 : Abreu, Aritonovska, Reichenbach, Cristofari, Culp, Terns, Lingner, Terns: TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. in Molecular and cellular biology 2010 (PubMed)
    Zeige alle 5 Referenzen für 395038

  2. Human Monoclonal ACD Primary Antibody für IF, IHC (p) - ABIN566298 : Frank, Tran, Qu, Stohr, Segal, Xu: The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres. in PLoS genetics 2015 (PubMed)
    Zeige alle 2 Referenzen für 566298

  3. Human Polyclonal ACD Primary Antibody für WB - ABIN2787610 : Hockemeyer, Palm, Else, Daniels, Takai, Ye, Keegan, de Lange, Hammer: Telomere protection by mammalian Pot1 requires interaction with Tpp1. in Nature structural & molecular biology 2007 (PubMed)

Weitere Antikörper gegen ACD Interaktionspartner

Mouse (Murine) Adrenocortical Dysplasia Homolog (Mouse) (ACD) Interaktionspartner

  1. shelterin protein TIN2 (zeige TINF2 Antikörper) can protect chromosome ends as a TRF2 (zeige TERF2 Antikörper)-tethered TIN2 (zeige TINF2 Antikörper)/TPP1 (zeige TPP1 Antikörper)/POT1 (zeige POT1 Antikörper) complex that lacks a physical connection to TRF1 (zeige TERF1 Antikörper)

  2. Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd.

  3. Tpp1 (zeige TPP1 Antikörper) is required for the protective function of Pot1 (zeige POT1 Antikörper) proteins.

  4. Tumors from Acd(acd/acd) p53 (zeige TP53 Antikörper)(+/-) mice show a striking switch from the classic spectrum of p53 (zeige TP53 Antikörper)(-/-) mice toward carcinomas.

Human Adrenocortical Dysplasia Homolog (Mouse) (ACD) Interaktionspartner

  1. a novel ACD mutation(p.G223V)is detected; ACD is a novel gene involved in childhood pre-B acute lymphoblastic leukemia and may play a functional role in enhancing leukemia cell survival

  2. The data support a causal relationship between a TPP1 (zeige TPP1 Antikörper) mutation and bone marrow disorders in a family.

  3. Clustering of novel mutations in the POT1 (zeige POT1 Antikörper) binding domain of ACD was statistically higher (P = .005) in melanoma probands compared with population control individuals (n = 6785).

  4. Shelterin protein TPP 1 (zeige TPP1 Antikörper) interacts with hTERT and recruits hTERT onto the telomeres, suggesting that TPP 1 (zeige TPP1 Antikörper) might be involved in regulation of telomere shortening.

  5. POT1 (zeige POT1 Antikörper)-TPP1 (zeige TPP1 Antikörper) binds telomeric DNA in a coordinated manner to facilitate assembly of the nucleoprotein complexes into a state that is more accessible to enzymatic activity.

  6. Study shows that the OB-fold domain of the telomere-binding protein TPP1 (zeige TPP1 Antikörper) recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT (zeige TERT Antikörper); data define a potential interface for telomerase-TPP1 (zeige TPP1 Antikörper) interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease.

  7. a paper that firstly reported cloning of human TTP1 (PTOP) and its biological function at telomere. TPP1 (zeige TPP1 Antikörper) interacts with both POT1 (zeige POT1 Antikörper) and TIN2 (zeige TINF2 Antikörper), heterodimerizes with POT1 (zeige POT1 Antikörper) and regulates POT1 (zeige POT1 Antikörper) telomeric recruitment and telomere length.

  8. The presence of dysfunctional telomeres in chronic lymphocytic leukemia did not correlate with telomere shortening or chromatin marks deregulation but with a down-regulation of 2 shelterin genes: ACD and TINF2 (zeige TINF2 Antikörper).

  9. Results support a model in which POT1 (zeige POT1 Antikörper)-TPP1 (zeige TPP1 Antikörper) enhances telomerase processivity in a manner markedly different from the sliding clamps used by DNA polymerases.

  10. TIN2 (zeige TINF2 Antikörper)-anchored TPP1 (zeige TPP1 Antikörper) plays a major role in the recruitment of telomerase to telomeres in human cells.

ACD Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.

Alternative names and synonyms associated with ACD

  • adrenocortical dysplasia homolog (mouse) (ACD) Antikörper
  • adrenocortical dysplasia homolog (mouse) (Acd) Antikörper
  • adrenocortical dysplasia (Acd) Antikörper
  • adrenocortical dysplasia homolog (LOC100346875) Antikörper
  • ACD Antikörper
  • PIP1 Antikörper
  • PTOP Antikörper
  • TINT1 Antikörper
  • TPP1 Antikörper

Bezeichner auf Proteinebene für ACD

POT1 and TIN2 organizing protein , POT1 and TIN2-interacting protein , TIN2 interacting protein 1 , adrenocortical dysplasia protein homolog , adrenocortical dysplasia homolog (mouse) , adrenocortical dysplasia protein

GENE ID SPEZIES
65057 Homo sapiens
307798 Rattus norvegicus
487931 Canis lupus familiaris
510353 Bos taurus
699230 Macaca mulatta
769451 Gallus gallus
497652 Mus musculus
100346875 Oryctolagus cuniculus
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