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anti-PKB (PKB) Antikörper

Bezeichnung:
anti-Protein Kinase B Antikörper (PKB)
Auf www.antikoerper-online.de finden Sie aktuell 8 Protein Kinase B (PKB) Antikörper von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PKB Kits (22) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 30 PKB Produkte verfügbar.
Synonyme:
AKT, CADTK, CAKB, FADK2, FAK2, PKB, PKB/Akt, PKBalpha, PTK, PYK2, Rac, RAFTK

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Am meisten referenzierte anti-PKB Antikörper

  1. Mouse (Murine) Polyclonal PKB Primary Antibody für IHC, WB - ABIN350718 : Anai, Shojima, Katagiri, Ogihara, Sakoda, Onishi, Ono, Fujishiro, Fukushima, Horike, Viana, Kikuchi, Noguchi, Takahashi, Takata, Oka, Uchijima, Kurihara, Asano: A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. in The Journal of biological chemistry 2005 (PubMed)
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Weitere Antikörper gegen PKB Interaktionspartner

Human Protein Kinase B (PKB) Interaktionspartner

  1. We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (zeige PIK3CA Antikörper)-Akt/PKB (zeige AKT1 Antikörper) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.

  2. PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.

  3. Studies suggest that PYK2 (zeige PTK2B Antikörper) is a common downstream effector of ErbB (zeige EGFR Antikörper) and IL8 (zeige IL8 Antikörper) receptors, and that PYK2 (zeige PTK2B Antikörper) integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

  4. Pyk2 (zeige PTK2B Antikörper) is a key downstream signaling molecules of CCR7 (zeige CCR7 Antikörper) in SCCHN, which promotes SCCHN tumorigenesis and progression.

  5. Phosphoproteomic analysis identifies FAK2 (zeige PTK2B Antikörper) as a potential therapeutic target for tamoxifen resistance in breast cancer.

  6. Pyk2 (zeige PTK2B Antikörper)-focal adhesion targeting domain interacts with and binds to leupaxin (zeige LPXN Antikörper).

  7. Src (zeige SRC Antikörper) has a role in priming Pyk2 (zeige PTK2B Antikörper) (but not FAK (zeige PTK2 Antikörper)) phosphorylation and subsequent activation downstream of integrins

  8. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  9. FAK (zeige PTK2 Antikörper) and PYK2 (zeige PTK2B Antikörper) functioned redundantly to promote the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway by phosphorylating GSK3beta (zeige GSK3b Antikörper)(Y216) to reinforce pathway output-beta-catenin (zeige CTNNB1 Antikörper) accumulation and intestinal tumorigenesis.

  10. This study identified Pyk2 (zeige PTK2B Antikörper) as a cellular component required for the intracellular trafficking of HPV16 during infection.

Mouse (Murine) Protein Kinase B (PKB) Interaktionspartner

  1. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt (zeige AKT1 Antikörper) phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atroph

  2. Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt (zeige AKT1 Antikörper) indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response

  3. Data show that Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) and MAPK (zeige MAPK1 Antikörper) pathways were activated in ovine pulmonary adenocarcinoma (OPA) lung and envelope (Env (zeige ERVW-1 Antikörper)) of Jaagsiekte sheep retrovirus (JSRV) transfected NIH 3T3 cells.

  4. Results suggest that SC79 compound activates Akt (zeige AKT1 Antikörper)-Nrf2 (zeige NFE2L2 Antikörper) signaling to protect osteoblasts from dexamethasone (Dex).

  5. In conclusion, we have identified that ARL15 acts as an insulin (zeige INS Antikörper)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (zeige IRS1 Antikörper)/PDPK1 (zeige PDPK1 Antikörper)/AKT (zeige AKT1 Antikörper) insulin (zeige INS Antikörper) pathway by interacting with its GAP ASAP2 (zeige ASAP2 Antikörper) and activating PDPK1 (zeige PDPK1 Antikörper). This research may provide new insights into GTPase (zeige RACGAP1 Antikörper)-mediated insulin (zeige INS Antikörper) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (zeige INS Antikörper) sensitizati

  6. Taken together, our findings imply that KLF15 possesses potential anti-hypertrophic and anti-fibrotic functions, possibly via regulation of cell death pathways and the inhibition of Akt/mTOR axis. KLF15 may constitute an efficient candidate drug for the treatment of heart failure and other cardiovascular diseases.

  7. Menin (zeige MEN1 Antikörper) binds on the promoter of Inhbb (zeige INHBB Antikörper) gene where it favours the recruitment of Ezh2 (zeige EZH2 Antikörper) via an indirect mechanism involving Akt (zeige AKT1 Antikörper)-phosphorylation.

  8. A role of AKT (zeige AKT1 Antikörper) in the regulatory T cell differentiation process. TGF-beta (zeige TGFB1 Antikörper) induces the phosphorylation of Akt (zeige AKT1 Antikörper) in CD4 (zeige CD4 Antikörper)+ T cells.

  9. 4-PBA reverses autophagic dysfunction and improves insulin (zeige INS Antikörper) sensitivity in adipose tissue of obese mice via Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling partly, which could be regarded as novel opportunities for treatment of insulin (zeige INS Antikörper) resistance.

  10. These studies reveal a novel mechanism in which CYP2J2 (zeige CYP2J2 Antikörper) and epoxyeicosatrienoic acids enhanced Akt1 (zeige AKT1 Antikörper) nuclear translocation through interaction with AMPKalpha2beta2gamma1 and protect against cardiac hypertrophy.

Pig (Porcine) Protein Kinase B (PKB) Interaktionspartner

  1. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (zeige AKT1 Antikörper)-mTOR (zeige FRAP1 Antikörper)-FOXO1 (zeige FOXO1 Antikörper) signaling and suppressing the activation of TLR4 (zeige TLR4 Antikörper) and/or NOD2 (zeige NOD2 Antikörper) signaling pathways.

  2. Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt (zeige AKT1 Antikörper) signaling pathway may be involved.

  3. In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 (zeige AKT1 Antikörper) could positively regulate lactose synthesis.

  4. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.

  5. Host PI3K and Akt1 (zeige AKT1 Antikörper) play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.

  6. Activity of AKT (zeige AKT1 Antikörper) is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

  7. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  8. findings show that megalin (zeige LRP2 Antikörper) is the sensor that determines whether cells will be protected or injured by albumin (zeige ALB Antikörper); it binds protein kinase B (PKB (zeige AKT1 Antikörper)) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB (zeige AKT1 Antikörper) in the luminal plasma membrane [

  9. protein kinase B (PKB/Akt (zeige AKT1 Antikörper))was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea

  10. Akt (zeige AKT1 Antikörper) signaling in porcine patellofemoral joint cartilage is dependent upon frequency of loading, cartilage zone, and the time interval between loading and cartilage harvest.

Goat Protein Kinase B (PKB) Interaktionspartner

  1. Exogenous AKT (zeige AKT1 Antikörper) was transcribed, and AKT (zeige AKT1 Antikörper) was overexpressed, inducing the phosphorylation of p70S6K (zeige RPS6KB1 Antikörper) (Thr389) and 4E-BP1 (zeige EIF4EBP1 Antikörper) (Thr37/46) in goat fetal fibroblasts.

Cow (Bovine) Protein Kinase B (PKB) Interaktionspartner

  1. These results demonstrate that activation of AKT (zeige AKT1 Antikörper) is required for gonadotropin regulation of CTNNB1 (zeige CTNNB1 Antikörper) accumulation and subsequent ovarian E2 production.

  2. Caveolin-1 (zeige CAV1 Antikörper) scaffolding domain residue phenylalanine 92 modulates Akt (zeige AKT1 Antikörper) signaling

  3. TG2 (zeige TGM2 Antikörper) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT (zeige AKT1 Antikörper) signaling, likely via its serotonylation.

  4. results suggest that PI3K-Akt (zeige AKT1 Antikörper) activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (zeige GSK3b Antikörper), and NF-kappaB (zeige NFKB1 Antikörper).

  5. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (zeige NOX1 Antikörper), reactive oxygen species, and PI3-kinase (zeige PIK3CA Antikörper) in stimulated NO release.

  6. PI3K/Akt (zeige AKT1 Antikörper) and p53 (zeige TP53 Antikörper) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  7. Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (zeige AKT1 Antikörper), mTOR (zeige FRAP1 Antikörper), p70S6K (zeige RPS6KB1 Antikörper), and ERK1/2 (zeige MAPK1/3 Antikörper).

  8. Gab1 (zeige GAB1 Antikörper) tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B (zeige AKT1 Antikörper) and endothelial nitric-oxide synthase (zeige NOS3 Antikörper) activation in endothelial cells

  9. Losartan metabolite stimulates eNOS (zeige NOS3 Antikörper) phosphorylation and suppresses tumor necrosis factor alpha (zeige TNF Antikörper)-induced endothelial cell apoptosis by activating AKT1 (zeige AKT1 Antikörper).

  10. prostaglandin F2alpha phosphorylates TSC2 (zeige TSC2 Antikörper) and activates mTOR (zeige FRAP1 Antikörper) and ribosomal protein S6 (zeige RPS6 Antikörper) kinase (zeige RPS6KB1 Antikörper) signaling in an AKT (zeige AKT1 Antikörper)-independent manner

PKB Antigen-Profil

Beschreibung des Gens

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PKB

  • protein tyrosine kinase 2 beta (PTK2B) Antikörper
  • thymoma viral proto-oncogene 1 (Akt1) Antikörper
  • v-akt murine thymoma viral oncogene homolog 1 (Akt1) Antikörper
  • v-akt murine thymoma viral oncogene homolog 1 (AKT1) Antikörper
  • v-akt murine thymoma viral oncogene homolog 2 (AKT2) Antikörper
  • AKT Antikörper
  • CADTK Antikörper
  • CAKB Antikörper
  • FADK2 Antikörper
  • FAK2 Antikörper
  • PKB Antikörper
  • PKB/Akt Antikörper
  • PKBalpha Antikörper
  • PTK Antikörper
  • PYK2 Antikörper
  • Rac Antikörper
  • RAFTK Antikörper

Bezeichner auf Proteinebene für anti-Protein Kinase B (PKB) Antikörper

CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , AKT1 kinase , PKB alpha , RAC-PK-alpha , RAC-alpha serine/threonine-protein kinase , protein kinase B alpha , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , RAC protein kinase alpha RAC-PK alpha , murine thymoma viral (v-akt) oncogene homolog 1 , thymoma viral proto-oncogene 1 , v-akt murine thymoma viral oncogene-like 1 , v-akt murine thymoma viral oncogene-like protein 1 , RAC-beta serine/threonine-protein kinase

GENE ID SPEZIES
2185 Homo sapiens
11651 Mus musculus
24185 Rattus norvegicus
100126861 Sus scrofa
100860904 Capra hircus
280991 Bos taurus
100294652 Ovis aries
449021 Canis lupus familiaris
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