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Human STIM1 ELISA Kit für Sandwich ELISA - ABIN824174
Wang, Sun, Huang, Wang, Hou, Sun, He, Krishna, Chiu, Lin, Yang, Chang: STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression. in Oncogene 2014
Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (zeige CA2 ELISA Kits)+) signal triggered by the fertilizing sperm.
findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (zeige CA2 ELISA Kits)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (zeige CA2 ELISA Kits)+) entry
STIM1 plays role in PAR1 (zeige F2R ELISA Kits)-mediated Ca2 (zeige CA2 ELISA Kits)+ influx and Ca2 (zeige CA2 ELISA Kits)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1
Stim1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
STIM1/TRPC1 (zeige TRPC1 ELISA Kits)-dependent store-operated Ca2 (zeige CA2 ELISA Kits)+ entry plays an essential role in generating spatiotemporal Ca2 (zeige CA2 ELISA Kits)+ signals that mediate guidance responses of nerve growth cones.
STIM1 and Orai1 (zeige ORAI1 ELISA Kits) are essential components of the signal transduction cascade that regulates sex pheromone production.
STIM1 contributes to the development of OTSCC.
Our findings demonstrate for the first time that STIM1 and store-operated calcium entry signaling are involved in the TGF-beta (zeige TGFB1 ELISA Kits)-induced suppression of cell proliferation
Cultured hippocampal neurons expressing mutant PS1 (zeige PSEN1 ELISA Kits) had attenuated CCE that was associated with destabilized dendritic spines, which were rescued by either gamma-secretase inhibition or overexpression of STIM1.
These findings suggest that the surface location of SARAF (zeige TMEM66 ELISA Kits) is dependent on the expression of STIM1 in the plasma membrane.
sp(2) -Iminosugar alpha-glucosidase (zeige AGLU ELISA Kits) inhibitor 1 (zeige PPP1R1A ELISA Kits)-C-octyl-2-oxa-3-oxocastanospermine inhibits breast cancer cell migration via beta1-integrin, Stim1, and FAK (zeige PTK2 ELISA Kits) signaling pathways.
The STIM1 protein play important roles in TGF-beta (zeige TGFB1 ELISA Kits)-induced EMT (zeige ITK ELISA Kits) and these effects are related to both store-operated calcium entry and non-store-operated calcium entry.
STIM1-dependent control of Ca2 (zeige CA2 ELISA Kits)+ clearance regulates NFAT (zeige NFATC1 ELISA Kits) activity during T-cell activation
RASSF4 (zeige RIN2 ELISA Kits) controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6 (zeige ARF6 ELISA Kits)-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes.
conformational changes in STIM1 upon calcium release
STIM1-induced Ca(2 (zeige CA2 ELISA Kits)+) signaling activates Pyk2 (zeige PTK2B ELISA Kits) to inhibit the interaction of VE-PTP (zeige PTPRB ELISA Kits) and VE-cadherin (zeige CDH5 ELISA Kits) and hence increase endothelial permeability.
STIM1 and STIM2 (zeige Stim2 ELISA Kits) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (zeige ITPR1 ELISA Kits).
Loss-of-function mutations in the Ca(2 (zeige CA2 ELISA Kits)+) release-activated Ca(2 (zeige CA2 ELISA Kits)+) channel genes ORAI1 (zeige TMEM132A ELISA Kits) and STIM1 abolish store-operated Ca(2 (zeige CA2 ELISA Kits)+) entry (SOCE) and result in ectodermal dysplasia with amelogenesis imperfecta. SOCE is essential for proper enamel mineralization, in which Stim1 plays a critical role during the maturation process.
Reactive oxygen species (ROS (zeige ROS1 ELISA Kits)) production, degranulation, and phagocytosis are normal in the absence of STIM2 (zeige Stim2 ELISA Kits), suggesting STIM1 is the dominant calcium sensor required for classical short-term neutrophil responses
Stromal interaction molecule 1 (STIM1), which regulates the refilling of ER Ca(2 (zeige CA2 ELISA Kits)+), has been investigated in several systems including the CNS. In addition to a previous study showing that STIM1 regulates dendritic ER Ca(2 (zeige CA2 ELISA Kits)+) refilling and mGluR1 (zeige GRM1 ELISA Kits)-mediated synaptic transmission, we provide compelling evidence describing a novel role of STIM1 in spike firing Purkinje neurons.
data indicate that STIM1 overexpression in neurons in the brain perturbs metabotropic glutamate (zeige GRIN1 ELISA Kits) receptor signaling, leading to impairments in long-term depression and alterations in animal behavior
Ca(2 (zeige CA2 ELISA Kits)+) entry serves critical cellular functions in virtually every cell type, and appropriate regulation of Ca(2 (zeige CA2 ELISA Kits)+) in neurons is essential for proper function.
suggests that STIM1 is a multifunctional signaling effector that participates in the control of membrane excitability and Ca(2 (zeige CA2 ELISA Kits)+) signaling events in beta-cells
vascular smooth muscle STIM1 plays a crucial role in the development of hypertension and associated cardiovascular pathologies.
Data show that the STIM1 Ksp (Eg5 (zeige KIF11 ELISA Kits))-cre knockout mice produced more urine compared to control.
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
stromal interaction molecule 1
, stromal interaction molecule 1b