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It has been shown that Dorsal repressed Ush expression levels to promote hemocytes differentiation, whereas Cactus maintained Ush levels to block differentiation.
CalpA targets free Cactus, which is incorporated into and modulates Toll (zeige TLR4 ELISA Kits)-responsive complexes in the embryo and immune system.
Dorsal and Cactus maybe necessary for normal function and maintenance of the neuromuscular system. These proteins can respond to synaptic activity.
Cactus acts as an inhibitor of the Rel-transcription factors Dorsal and Dif (zeige TNF ELISA Kits).
immune-induced degradation does not require CSN5 (zeige COPS5 ELISA Kits)
Dpp signals increase Cactus levels through Calpain A inhibition, thereby interfering with Dorsal activation
We provide evidence that the downregulation of hsa (zeige CD24 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-124-3p, hsa (zeige CD24 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-129-5p and hsa (zeige CD24 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-378 induced an increase in both expression and activity of CPT1A (zeige CPT1A ELISA Kits), CACT and CrAT (zeige CRAT ELISA Kits) in malignant prostate cells.
The antiport mode of transport, typical of mitochondrial carriers such as CAC (zeige CA2 ELISA Kits), results from coupling of uniport reactions in opposite directions mediated by specific amino acid residues.
C.576G>A, c.106-2a>t and c.516T>C are novel CACT gene mutations.
CPT2 (zeige CPT2 ELISA Kits) and CACT are crucial for mitochondrial acylcarnitine formation and export to the extracellular fluids in mitochondrial fatty acid beta-oxidation disorders.
Compares and contrasts all the known human SLC25A (zeige SLC25A25 ELISA Kits)* genes and includes functional information.
Results show Steroid Receptor Coactivator (zeige SRA1 ELISA Kits)-3 (SRC-3 (zeige NCOA3 ELISA Kits)) plays a central role in long chain fatty acid metabolism by directly regulating carnitine/acyl-carnitine translocase (CACT) gene expression.
These results show that FOXA and Sp1 (zeige PSG1 ELISA Kits) sites in HepG2 cells and only the Sp1 (zeige PSG1 ELISA Kits) site in HEK293 and SK-N-SH cells have a critical role in the transcriptional regulation of the CAC (zeige CA2 ELISA Kits) proximal promoter.
A deficiency in CACT was treated with a carnitine diet and administration of medium-chain triglycerides.
The clinical, biochemical, & molecular features of 6 CACT-deficient patients from Italy, Spain, & North America who had significant clinical heterogeneity are reported. 5 novel & 3 previously reported mutations were found.
The modulation of CACT expression has consequences for CPT 1 (zeige CPT1A ELISA Kits) activity, while the biologic effects of acetyl-carnitine are not associated with a generic supply of energy compounds but to the anaplerotic property of the molecule.
the 50-flanking region of the Cact gene contains a consensus sequence for ERRalpha (zeige ESRRA ELISA Kits). This sequence binds ERRa (zeige ESRRA ELISA Kits) both in vivo and in vitro and is required for the activation of Cact expression by the PGC-1 (zeige PPARGC1A ELISA Kits)/ERR (zeige SLC7A1 ELISA Kits) axis
Data show that the upregulation of CACT by PPARalpha (zeige PPARA ELISA Kits) and PPARdelta (zeige PPARD ELISA Kits) may increase the import of acylcarnitine into the mitochondrial matrix during fasting.
This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants.
, NF-kappa-B inhibitor cactus
, solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
, carnitine/acylcarnitine translocase
, mitochondrial carnitine/acylcarnitine carrier protein
, solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
, solute carrier family 25 member 20
, protein kinase, cAMP-dependent, regulatory, type II, alpha
, carnitine/acylcarnitine carrier protein
, mitochondrial carnitine-acylcarnitine translocase