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signaling underpins thymic selection processes induced by both weak and strong TCR signals and is differentially required for fate decisions derived from a strong TCR stimulus
RasGRP1/3-deficient progenitors show impaired migration toward the CCR9 (zeige CCR9 Antikörper) ligand, CCL25 (zeige CCL25 Antikörper), suggesting that RasGRP1 and RasGRP3 (zeige RASGRP3 Antikörper) may regulate progenitor entry into the thymus through a CCR9 (zeige CCR9 Antikörper)-dependent mechanism.
RasGRP1 is indispensable for development of B1a cells with autoantigen receptors, revealing a connection between a signaling molecule and development of a specific repertoire within the B1a cell population
Genetic Rasgrp1 depletion from mice with either an activating mutation in KRas or with aberrant Wnt (zeige WNT2 Antikörper) signalling due to a mutation in Apc (zeige APC Antikörper) resulted in both cases in exacerbated Ras-ERK (zeige EPHB2 Antikörper) signalling and cell proliferation.
CD44 (zeige CD44 Antikörper) expression, CD4 (zeige CD4 Antikörper)(+) T cell subset ratios and serum autoantibodies all returned to normal in Rasgrp1(Anaef)Mtor (zeige FRAP1 Antikörper)(chino) double-mutant mice
RasGRP1 upregulates signaling from Ras and contributes to epidermal tumorigenesis by increasing the total dosage of active Ras.
autoreactive B cells lacking Rasgrp1 break central and peripheral tolerance through both T cell-independent and -dependent mechanisms.
Dysregulated RasGRP1 responds to cytokine receptor (zeige LEPR Antikörper) input in T cell leukemogenesis.
RasGRP1, but not RasGRP3 (zeige RASGRP3 Antikörper), is required for thymocyte positive selection and invariant natural killer T cell selection.
Genetic analysis shows that disease progression and ERK (zeige EPHB2 Antikörper) signaling are dependent on RAS guanine exchange factor (zeige SOS1 Antikörper) responsible for ERK (zeige EPHB2 Antikörper) activation and lymphoproliferative phenotype in LAT (zeige LAT Antikörper)-Y136F mutant mice.
Cytokines IL-2 (zeige IL2 Antikörper)/7/9 stimulation activates PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) pathways downstream of Ras in RasGRP1 T-cell acute lymphoblastic leukemia (T-ALL).
results demonstrate the critical role of CalDAG-GEFI in rapid alphaIIbbeta3 activation of human platelets.
This study shows that deficiency in RASGRP1 results in a previously unknown primary immunodeficiency disease, and that RASGRP1 plays role in immune cell signaling and function in T cells, B cells and NK cells. It also identifies a previously unknown role for RASGRP1 in the dynamic regulation of the cytoskeleton, and identify lenalidomide as a potpotential treatment option for this immunodeficiency.
This study aimed to replicate and verify the association of RASGRP1 tag single-nucleotide polymorphisms with T2D in a Chinese Han population.
present a crystal structure of a fragment of RasGRP1 in which the Ras-binding site is blocked by an interdomain linker and the membrane-interaction surface of RasGRP1 is hidden within a dimerization interface
A genome-wide association study identifies GRK5 (zeige GRK5 Antikörper) and RASGRP1 as type 2 diabetes loci in Chinese Hans.
This is the first study aimed at evaluating CalDAG-GEFI gene sequences in people with mucocutaneous bleeding of unknown cause.
PAQR10 and PAQR11 are able to interact with RasGRP1, a guanine nucleotide exchange protein of Ras, and increase Golgi localization of RasGRP1. The C1 domain of RasGRP1 is both necessary and sufficient for the interaction of RasGRP1 with PAQR10/PAQR11.
cooperation between aberrant expression of RasGRP1, a strong activator of Ras, and secondary gain-of-function mutations of NOTCH1 (zeige NOTCH1 Antikörper) have an important role in T-cell leukemogenesis
remission in systemic lupus erythematosus activity associated with decreased RasGRP-1 expression in lymphocytes
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
RAS guanyl-releasing protein 1
, calcium and DAG-regulated guanine nucleotide exchange factor II
, RAS guanyl nucleotide-releasing protein 1
, guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A
, ras activator RasGRP