anti-LCP2 (LCP2) Antikörper

Bezeichnung:
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) Antikörper (LCP2)
Auf www.antikoerper-online.de finden Sie aktuell 155 Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen LCP2 Proteine (9) und LCP2 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 177 LCP2 Produkte verfügbar.
Synonyme:
AI323664, BB161688, SLP-76, Slp76, twm

Meistgesuchte Reaktivitäten zu anti-LCP2 (LCP2) Antikörper

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anti-Mouse (Murine) LCP2 Antikörper:

anti-Rat (Rattus) LCP2 Antikörper:

anti-Human LCP2 Antikörper:

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Am meisten referenzierte anti-LCP2 Antikörper

  1. Human Monoclonal LCP2 Primary Antibody für IF, IP - ABIN968146 : Harder, Kuhn: Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies. in The Journal of cell biology 2000 (PubMed)
    Zeige alle 5 Referenzen für 968146

  2. Human Monoclonal LCP2 Primary Antibody für IHC (p), WB - ABIN94466 : Silverman, Shoag, Wu, Koretzky: Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. in Molecular and cellular biology 2006 (PubMed)
    Zeige alle 4 Referenzen für 94466

  3. Human Monoclonal LCP2 Primary Antibody für WB - ABIN967606 : Fang, Motto, Ross, Koretzky: Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity. in Journal of immunology (Baltimore, Md. : 1950) 1996 (PubMed)
    Zeige alle 3 Referenzen für 967606

  4. Human Monoclonal LCP2 Primary Antibody für WB - ABIN967597 : Janssen, Zhang: Adaptor proteins in lymphocyte activation. in Current opinion in immunology 2003 (PubMed)
    Zeige alle 3 Referenzen für 967597

  5. Human Monoclonal LCP2 Primary Antibody für IP, WB - ABIN264523 : Jackman, Motto, Sun, Tanemoto, Turck, Peltz, Koretzky, Findell: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. in The Journal of biological chemistry 1995 (PubMed)
    Zeige alle 2 Referenzen für 264523

  6. Human Monoclonal LCP2 Primary Antibody für ICS - ABIN1177173 : Wu, Koretzky: The SLP-76 family of adapter proteins. in Seminars in immunology 2004 (PubMed)
    Zeige alle 2 Referenzen für 1177173

  7. Human Monoclonal LCP2 Primary Antibody für IHC (p), IHC - ABIN269168 : Lin, Liu, Moore, Elizer, Veach, Hawiger, Ruley: Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes. in Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)

  8. Human Polyclonal LCP2 Primary Antibody für IHC, ELISA - ABIN1532089 : Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ... in The Journal of biological chemistry 2012 (PubMed)

Weitere Antikörper gegen LCP2 Interaktionspartner

Mouse (Murine) Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) Interaktionspartner

  1. Biochemical analyses revealed that mutant T cells were hypersensitive to TCR stimulation. Indeed, phosphorylation of several signaling proteins, including SLP76 itself, phospholipase Cgamma1 and the protein kinases AKT (zeige AKT1 Antikörper) and ERK1/2 (zeige MAPK1/3 Antikörper), was increased

  2. slp-76 contributes to the regulation of the tissue distribution, PLZF (zeige ZBTB16 Antikörper), and cytokine expression of iNKT cells via ADAP (zeige APP Antikörper)-dependent and -independent mechanisms.

  3. findings identify ACK1 (zeige TNK2 Antikörper) as a novel SLP-76-associated protein-tyrosine kinase (zeige YES1 Antikörper) that modulates early activation events in T cells.

  4. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (zeige RANGAP1 Antikörper) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (zeige NFATC1 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) p65 (zeige NFkBP65 Antikörper) nuclear entry in T cells

  5. these studies establish Slp-76 as a critical determinant of NK-cell development and NK cell mediated elimination of missing-self target cells in mice

  6. Data show that a splice variant of SLP-76 signal transducing adaptor protein (SLP-76 or Lcp2) reduced the amount of SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees.

  7. this analysis identified 65 proteins not associated before with the Zap70 (zeige ZAP70 Antikörper)-Lat (zeige LAT Antikörper)-SLP-76 network and thus should provide cues for future functional experiments.

  8. A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1 (zeige PRAM1 Antikörper)/SKAP-HOM (zeige SKAP2 Antikörper) and SLP-76/Vav (zeige VAV1 Antikörper)/PLCgamma2 (zeige PLCG2 Antikörper) signaling hubs may be critical for Yersinia survival.

  9. analysis of a costimulatory mechanism by which CXCL12 (zeige CXCL12 Antikörper) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

  10. Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI (zeige FCER1A Antikörper) and the IL-3 (zeige IL-3 Antikörper) receptor.

Human Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) Interaktionspartner

  1. These data are consistent with a model in which bivalent recruitment of a GADS (zeige GRAP2 Antikörper)/SLP-76 complex is required for costimulation by CD6 (zeige CD6 Antikörper).

  2. LAT (zeige ORC3 Antikörper) and SLP-76 are randomly dispersed throughout the clusters that form upon T cell receptor engagement.

  3. SLP76 is ectopically expressed in chronic lymphocytic leukemia cells where it plays a role in B-cell receptor signaling.

  4. findings identify ACK1 (zeige TNK2 Antikörper) as a novel SLP-76-associated protein-tyrosine kinase (zeige EPHA8 Antikörper) that modulates early activation events in T cells.

  5. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  6. TSAD (zeige SH2D2A Antikörper) binds to and co-localizes with Nck (zeige NCK1 Antikörper). Expression of TSAD (zeige SH2D2A Antikörper) increases both Nck (zeige NCK1 Antikörper)-Lck (zeige LCK Antikörper) and Nck (zeige NCK1 Antikörper)-SLP-76 interaction in T cells.

  7. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (zeige RANGAP1 Antikörper) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (zeige NFATC1 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) p65 (zeige GORASP1 Antikörper) nuclear entry in T cells

  8. SLP-76 N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor signaling

  9. analysis of a costimulatory mechanism by which CXCL12 (zeige CXCL12 Antikörper) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

  10. Multipoint binding of SLP-76 to ADAP (zeige FYB Antikörper) facilitates the assembly of SLP-76 microclusters.

LCP2 Antigen-Profil

Beschreibung des Gens

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Alternative names and synonyms associated with LCP2

  • lymphocyte cytosolic protein 2 (Lcp2) Antikörper
  • lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2) Antikörper
  • AI323664 Antikörper
  • BB161688 Antikörper
  • SLP-76 Antikörper
  • Slp76 Antikörper
  • twm Antikörper

Bezeichner auf Proteinebene für LCP2

SH2 domain-containing leukocyte protein of 76 kDa , SLP-76 tyrosine phosphoprotein , lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD) , 76 kDa tyrosine phosphoprotein , SH2 domain-containing leukocyte protein of 76kD , lymphocyte cytosolic protein 2 , tyrosine phosphoprotein slp-76

GENE ID SPEZIES
16822 Mus musculus
155918 Rattus norvegicus
3937 Homo sapiens
100511843 Sus scrofa
489126 Canis lupus familiaris
513244 Bos taurus
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