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Overexpression of LAT (zeige ORC3 ELISA Kits) is associated with microcephaly.
LAT (zeige ORC3 ELISA Kits) and SLP-76 (zeige LCP2 ELISA Kits) are randomly dispersed throughout the clusters that form upon T cell receptor engagement.
this study shows that inherited LAT (zeige ORC3 ELISA Kits) deficiency should be considered in patients with combined immunodeficiency with T-cell abnormalities
This is the first report of a LAT (zeige ORC3 ELISA Kits)-related disease in humans, manifesting by a progressive combined immune deficiency with severe autoimmune disease.
Data show that LAT1 plays an important role in regulating the uptake of essential amino acids such as leucine into endometrial cancer cells. Increased ability of BCH (zeige CHN2 ELISA Kits) compared to LAT1 shRNA at inhibiting Ishikawa spheroid area suggests that other LAT (zeige ORC3 ELISA Kits) family members may also contribute to cell growth.
Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen (zeige CD6 ELISA Kits) and linker for activation of T cells protein (LAT (zeige ORC3 ELISA Kits)) phosphotyrosine (pTyr) peptides.
High expression of LAT1 and ASCT2 (zeige SLC1A5 ELISA Kits) correlates with metastasis and invasion in esophageal squamous cell carcinoma.
IFT20 (zeige IFT20 ELISA Kits) is required for the delivery of the intracellular pool of LAT (zeige ORC3 ELISA Kits) to the immune synapse in naive primary T lymphocytes.
Data show that the palmitoylation mutation of linker for activation of T cells (LAT)attenuated the signal transduction induced by glycosylphosphatidylinositol-anchored CD59 antigen (zeige CD59 ELISA Kits) in T cells.
HSV-1-encoded Us3 protein interrupted TCR signaling and interleukin-2 (zeige IL2 ELISA Kits) production by inactivation of the linker for activation of T cells.
this study shows that the site-specific delivery of linker for activation of T cells (LAT) in asthmatic mouse model
IFT20 (zeige IFT20 ELISA Kits) is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
miR (zeige MLXIP ELISA Kits)-155 regulates the delicate balance between PAK1 (zeige PAK1 ELISA Kits)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
provide evidence that CD28 (zeige CD28 ELISA Kits) and the TCR complex regulate NF-kappaB (zeige NFKB1 ELISA Kits) via different signaling modules of GRB-2 (zeige GRB2 ELISA Kits)/VAV1 (zeige VAV1 ELISA Kits) and LAT/ADAP (zeige APP ELISA Kits) pathways respectively.
The result indicate that LAT-PLCg1 (zeige PLCG1 ELISA Kits) interaction is important for controlling IL-6 (zeige IL6 ELISA Kits) production by T cells and demonstrate a critical role of IL-6 (zeige IL6 ELISA Kits) in the development of the lymphoproliferative syndrome.
low level of LAT-PLC-gamma1 (zeige PLCG1 ELISA Kits) interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT and PLCgamma1 (zeige PLCG1 ELISA Kits) in Dow2-induced anergic T cells. The novel CD3 (zeige CD3E ELISA Kits)-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
Sos1 (zeige SOS1 ELISA Kits) has distinct roles in acting as a scaffold to oligomerize the adaptor protein LAT, and in guanine nucleotide exchange activity
this analysis identified 65 proteins not associated before with the Zap70 (zeige ZAP70 ELISA Kits)-Lat-SLP-76 (zeige LCP2 ELISA Kits) network and thus should provide cues for future functional experiments.
Data suggest that transmembrane adaptor protein LAT-PLCgamma1 (Phospholipase C gamma 1 (zeige PLCG1 ELISA Kits)) signaling may function differently in various subsets of gammadelta T cells.
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
linker for activation of T cells
, 36 kDa phospho-tyrosine adapter protein
, 36 kDa phospho-tyrosine adaptor protein
, linker for activation of T cells, transmembrane adaptor
, linker for activation of T-cells family member 1
, linker protein