ITK Proteine (ITK)

Bezeichnung:
IL2-Inducible T-Cell Kinase Proteine (ITK)
Auf www.antikoerper-online.de finden Sie aktuell 15 IL2-Inducible T-Cell Kinase (ITK) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ITK Antikörper (122) und ITK Kits (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 156 ITK Produkte verfügbar.
Synonyme:
EMT, LPFS1, LYK, PSCTK2, Tcsk, Tsk
alle Proteine anzeigen Gen GeneID UniProt
ITK 16428 Q03526
ITK 3702 Q08881
ITK 363577  

Weitere Synonyme anzeigen

ITK Proteine (ITK) nach Spezies

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Am meisten referenzierte ITK Proteine

  1. Mouse (Murine) ITK Protein expressed in Baculovirus infected Insect Cells - ABIN2007712 : Pechloff, Holch, Ferch, Schweneker, Brunner, Kremer, Sparwasser, Quintanilla-Martinez, Zimber-Strobl, Streubel, Gewies, Peschel, Ruland: The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. in The Journal of experimental medicine 2010 (PubMed)

Weitere Proteine zu ITK Interaktionspartnern

Mouse (Murine) IL2-Inducible T-Cell Kinase (ITK) Interaktionspartner

  1. Our results provide new insight into the effect of ITK and suboptimal T-cell receptor signaling on CD8 (zeige CD8A Proteine)(+) T cell function, and how these may contribute to phenotypes associated with ITK deficiency

  2. Data suggest that the pleckstrin homology domain of Itk functions as a phospholipid bilayer recognition site that localizes Itk to membrane via phosphatidylinositol 3,4,5-trisphosphate (PIP3) binding; this specific binding inhibits the phospho-transfer reaction via an allosteric mechanism.

  3. pharmacological inhibition of ITK resulted in T cell hyperplasia and the increased production of TH2-type cytokines.

  4. ITK and BTK (zeige BTK Proteine) regulate thermal homeostasis during septic response through mast cell function in mice.

  5. Taken together, these data indicate that ITK plus RLK (zeige TXK Proteine) inhibition may have therapeutic potential in Th1 (zeige HAND1 Proteine)-mediated inflammatory diseases.

  6. This work has important implications for understanding the role of Itk signaling in the development versus function of iNKT cells, Th1 (zeige HAND1 Proteine), Th2, and Th17 cells.

  7. The kinase Itk and the adaptor TSAd (zeige SH2D2A Proteine) change the specificity of the kinase Lck (zeige LCK Proteine) in T cells by promoting the phosphorylation of Tyr192.

  8. Data indicate that the interleukin-2 (zeige IL2 Proteine) inducible tyrosine kinase (zeige TYRO3 Proteine) K390R point mutation (Itk-KD) transgenic mice were largely protected from inflammatory symptoms in an Ovalbumin (zeige OVA Proteine) model of airway inflammation.

  9. The Itk pleckstrin (zeige PLEK Proteine) homology domain binds to Calmodulin (zeige Calm2 Proteine) and PI(3,4,5)Pto promote efficient calcium signaling and IL-17A (zeige IL17A Proteine) production.

  10. Signaling by Itk promotes autoimmunity and CNS inflammation.

Human IL2-Inducible T-Cell Kinase (ITK) Interaktionspartner

  1. Our results provide new insight into the effect of ITK and suboptimal T-cell receptor signaling on CD8 (zeige CD8A Proteine)(+) T cell function, and how these may contribute to phenotypes associated with ITK deficiency

  2. The data indicate that increased ITK expression could act as a disease activity marker and as a risk factor for involvement in SLE, but it still needs further study to confirm.

  3. We conclude that ITK, formerly considered an immune cell-specific protein, is aberrantly expressed in melanoma and promotes tumor development and progression

  4. The kinase Itk and the adaptor TSAd (zeige SH2D2A Proteine) change the specificity of the kinase Lck (zeige LCK Proteine) in T cells by promoting the phosphorylation of Tyr192.

  5. Found that 38% and 14% of the Angioimmunoblastic T-cell lymphoma cases exhibited gains of ITK and SYK (zeige SYK Proteine) genes, respectively.

  6. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK (zeige TXK Proteine), and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.

  7. approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR (zeige EGFR Proteine) in EGFR (zeige EGFR Proteine)-dependent PC9 (zeige PCSK9 Proteine) cells, and these genes include seven of nine Src (zeige SRC Proteine) family kinase genes, FGFR1 (zeige FGFR1 Proteine), FGFR2 (zeige FGFR2 Proteine), ITK, NTRK1 (zeige NTRK1 Proteine), NTRK2 (zeige NTRK2 Proteine), MOS (zeige MOS Proteine), MST1R (zeige MST1R Proteine), and RAF1 (zeige RAF1 Proteine).

  8. ITK deficiency is a genetic cause of idiopathic CD4 (zeige CD4 Proteine)+ T-cell lymphopenia.

  9. Data indicate reduced T-cell activation by altered IL-2 inducible T-cell kinase (ITK) expression in vitro.

  10. T-cell-specific human ITK-Syk (zeige SYK Proteine) oncogene (zeige RAB1A Proteine) in mice leads to early polyclonal T cell lymphoproliferation (zeige FAS Proteine) with B cell expansion. It induces terminal T cell differentiation via Blimp-1 (zeige PRDM1 Proteine), eliminating oncogene (zeige RAB1A Proteine)-expressing cells early in development.

ITK Protein Überblick

Protein Überblick

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.

Alternative names and synonyms associated with ITK

  • IL2 inducible T cell kinase (Itk)
  • IL2-inducible T-cell kinase (ITK)
  • IL2-inducible T-cell kinase (Itk)
  • EMT Protein
  • LPFS1 Protein
  • LYK Protein
  • PSCTK2 Protein
  • Tcsk Protein
  • Tsk Protein

Bezeichner auf Proteinebene für ITK

T-cell-specific kinase , interleukin-2-inducible T cell kinase , kinase TLK , tyrosine-protein kinase ITK/TSK , IL-2-inducible T cell kinase , IL-2-inducible T-cell kinase , homolog of mouse T-cell itk/tsk , interleukin-2-inducible T-cell kinase , kinase EMT , tyrosine-protein kinase LYK

GENE ID SPEZIES
16428 Mus musculus
3702 Homo sapiens
363577 Rattus norvegicus
489159 Canis lupus familiaris
100523474 Sus scrofa
522311 Bos taurus
416247 Gallus gallus
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