anti-Human CCR5 Antikörper für Fluorescence Microscopy

Recommended CCR5 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
C-C Chemokine Receptor Type 5 (CCR5) Antikörper
  • CC-CKR-5
  • CCCKR5
  • CCR-5
  • CD195
  • CKR-5
  • CKR5
  • CMKBR5
  • IDDM22
  • Ckr5
  • Cmkbr5
  • CCR1-L
  • GPCR
  • CCR5
  • AM4-7
  • CCR5-L
  • chemokine (C-C motif) receptor 5 (gene/pseudogene)
  • chemokine (C-C motif) receptor 5
  • chemokine (C-C motif) receptor 2
  • C-C chemokine receptor type 5-like
  • CCR5
  • Ccr5
  • CCR2
  • LOC100399144
Reaktivität
Human
517
87
72
14
14
3
2
1
1
1
1
1
Wirt
Maus
270
182
72
15
14
Klonalität
Monoklonal
Konjugat
Dieser CCR5 Antikörper ist unkonjugiert
47
27
24
23
20
17
15
14
13
13
13
8
6
6
5
5
5
5
4
4
4
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
Fluorescence Microscopy (FM), Flow Cytometry (FACS)
345
210
141
66
64
58
57
33
29
18
14
12
12
8
6
5
4
4
3
3
2
2
2
2
1
1
Optionen
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Produktnummer ABIN2689053
Preis und Verfügbarkeit auf Anfrage.

General

Antigen C-C Chemokine Receptor Type 5 (CCR5) Antikörper
Reaktivität Human
(517), (87), (72), (14), (14), (3), (2), (1), (1), (1), (1), (1)
Wirt Maus
(270), (182), (72), (15), (14)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser CCR5 Antikörper ist unkonjugiert
(47), (27), (24), (23), (20), (17), (15), (14), (13), (13), (13), (8), (6), (6), (5), (5), (5), (5), (4), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Applikation Fluorescence Microscopy (FM), Flow Cytometry (FACS)
(345), (210), (141), (66), (64), (58), (57), (33), (29), (18), (14), (12), (12), (8), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1)
Pubmed 8 Publikationen vorhanden
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Produktdetails anti-CCR5 Antikörper

Target Details CCR5 Anwendungsinformationen Handhabung Referenzen für anti-CCR5 Antikörper (ABIN2689053) Bilder
Marke BD Pharmingen™
Produktmerkmale Reacts with the chemokine receptor, CCR5, a seven transmembrane-spanning G protein-associated molecule. 3A9 antibody has also been reported to cross-react with human CCR8. Results of epitope mapping and sequence comparison between CCR5 and CCR8 reveals that the first three amino acid residues for these two receptors are identical: MDY (Met-Asp-Tyr). CCR5 belongs to the β-chemokine receptor family. It is expressed on a subset of T lymphocytes (CD3+, CD45RO+, CD95+). CCR5 regulates lymphocyte chemotaxis activation and transendothelial migration during inflammation. It signals a response to at least three chemokines: RANTES and macrophage inflammatory protein-1 (MIP-1) α and β. Additionally, CCR5 has been found to be a co-receptor for macrophage-tropic HIV-1 on CD4+ cells, a characteristic that is important in viral transmission. Reports indicate that individuals who have partial (heterozygous) or complete (homozygous) deletion of the CCR5 allele, demonstrate resistance to HIV infection. CCR5 has been clustered as CD195 in the VIIth HLDA workshop. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD195 - Purified - Clone 3A9 - Isotype Mouse IgG2a, κ - Reactivity Hu - 0.1 mg
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Klon 3A9
Isotyp IgG2a, kappa

Target Details CCR5

Produktdetails anti-CCR5 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CCR5 Antikörper (ABIN2689053) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD195 (CCR5 Antibody Abstract)
Hintergrund Synonyms: CCR5
Pathways Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size

Anwendungsinformationen

Produktdetails anti-CCR5 Antikörper Target Details CCR5 Handhabung Referenzen für anti-CCR5 Antikörper (ABIN2689053) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CCR5 Antikörper Target Details CCR5 Anwendungsinformationen Referenzen für anti-CCR5 Antikörper (ABIN2689053) Bilder zurück nach oben
Konzentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store undiluted at 4°C.

Referenzen für anti-CCR5 Antikörper (ABIN2689053)

Produktdetails anti-CCR5 Antikörper Target Details CCR5 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Hancock: "Chemokines and the pathogenesis of T cell-dependent immune responses." in: The American journal of pathology, Vol. 148, Issue 3, pp. 681-4, 1997

Rottman, Ganley, Williams, Wu, Mackay, Ringler: "Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection." in: The American journal of pathology, Vol. 151, Issue 5, pp. 1341-51, 1997

Wu, Paxton, Kassam, Ruffing, Rottman, Sullivan, Choe, Sodroski, Newman, Koup, Mackay: "CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro." in: The Journal of experimental medicine, Vol. 185, Issue 9, pp. 1681-91, 1997

Choe, Farzan, Sun, Sullivan, Rollins, Ponath, Wu, Mackay, LaRosa, Newman, Gerard, Gerard, Sodroski: "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates." in: Cell, Vol. 85, Issue 7, pp. 1135-48, 1996

Deng, Liu, Ellmeier, Choe, Unutmaz, Burkhart, Di Marzio, Marmon, Sutton, Hill, Davis, Peiper, Schall, Littman, Landau: "Identification of a major co-receptor for primary isolates of HIV-1." in: Nature, Vol. 381, Issue 6584, pp. 661-6, 1996

Doranz, Rucker, Yi, Smyth, Samson, Peiper, Parmentier, Collman, Doms: "A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors." in: Cell, Vol. 85, Issue 7, pp. 1149-58, 1996

Dragic, Litwin, Allaway, Martin, Huang, Nagashima, Cayanan, Maddon, Koup, Moore, Paxton: "HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5." in: Nature, Vol. 381, Issue 6584, pp. 667-73, 1996

Raport, Gosling, Schweickart, Gray, Charo: "Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha." in: The Journal of biological chemistry, Vol. 271, Issue 29, pp. 17161-6, 1996