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Aurora A (zeige AURKA ELISA Kits) and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Regulation of Polo (zeige PLK1 ELISA Kits) by Aurora B and Map205 is required for cytokinesis.
We propose that mutual inhibitions between Aurora B a (zeige CDK1 ELISA Kits)nd Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
Aurora B interacts with and requires the Cdc37 (zeige CDC37 ELISA Kits)/Hsp90 (zeige HSP90 ELISA Kits) complex for its stability.
INCENP (zeige INCENP ELISA Kits) binds to the cohesion protector protein (zeige PRDX2 ELISA Kits) MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Our findings suggested that AURKA (zeige AURKA ELISA Kits) (rs911160) and AURKB (rs2289590) polymorphisms could affect GC risk. Further validation studies in larger and multi-ethnical populations are needed to elucidate their functional impact on the development of GC
Data show that aurora-B regulates end-on conversion in human cells and indicate a late role for SPAG5 (zeige SPAG5 ELISA Kits) protein (Astrin (zeige SPAG5 ELISA Kits))-SKAP (zeige KNSTRN ELISA Kits) complex in the end-on conversion process.
The results of experiment indicated that specific knockdown of Aurora kinase B led to prostate carcinoma cells apoptosis and inhibited tumor growth.
decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms.
Aurora B kinase interacts with and phosphorylates Sgo1 (zeige SGOL1 ELISA Kits). Aurora B-mediated phosphorylation of Sgo1 (zeige SGOL1 ELISA Kits) regulates the distribution of Sgo1 (zeige SGOL1 ELISA Kits) between centromeres and chromosome arms.
AURKC (zeige AURKC ELISA Kits) rs758099 TT and (CC + CT) genotypes were positively associated with increased intestinal type gastric cancer (GC)risk, but not with an increased diffuse type GC risk. Based on these results, we can conclude that AURKA (zeige AURKA ELISA Kits) rs1047972 and AURKC (zeige AURKC ELISA Kits) rs758099 polymorphisms could affect the risk of GC development.
Aurora-C (zeige AURKC ELISA Kits) interactions with members of the Chromosome Passenger Complex (CPC), Survivin (zeige BIRC5 ELISA Kits) and Inner Centromere Protein (INCENP (zeige INCENP ELISA Kits)) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C (zeige AURKC ELISA Kits) overexpression in human cancer cells, is reported.
Aurora kinase (zeige AURKA ELISA Kits) inhibitor danusertib negatively regulated AURKB/p70S6K (zeige RPS6KB1 ELISA Kits)/RPL15 (zeige RPL15 ELISA Kits) axis with the involvement of PI3K (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits), AMPK (zeige PRKAA1 ELISA Kits), and p38 MAPK (zeige MAPK14 ELISA Kits) signaling pathways, leading to the induction of apoptosis and autophagy in human leukemia cells.
The kinase activity of Aurora B on serine 31 of histone H3.3 (zeige H3F3A ELISA Kits) was biochemically confirmed with nucleosomal substrates in vitro.
in addition to its role in checkpoint signaling, MAD2 (zeige MAD2L1 ELISA Kits) ensures chromosome stability through the regulation of AURORA B.
Loss of AURKB function affects TERF1 (zeige TERF1 ELISA Kits) telomere binding and results in aberrant telomere structure.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB or AURKC (zeige AURKC ELISA Kits) using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA (zeige AURKA ELISA Kits) expression is crucial for spindle formation in meiosis
Aurkb phosphorylates Oct4 (zeige POU5F1 ELISA Kits)(S229) during G2/M phase, leading to the dissociation of Oct4 (zeige POU5F1 ELISA Kits) from chromatin, whereas PP1 (zeige PPP1CC ELISA Kits) binds Oct4 (zeige POU5F1 ELISA Kits) and dephosphorylates Oct4 (zeige POU5F1 ELISA Kits)(S229) during M/G1 transition, which resets Oct4 (zeige POU5F1 ELISA Kits)-driven transcription for pluripotency and the cell cycle.
Overexpression of Aurora B (zeige AURKC ELISA Kits) also results in a reduced DNA damage response and decreased levels of the p53 (zeige TP53 ELISA Kits) target p21(Cip1 (zeige CDKN1A ELISA Kits)) in vitro and in vivo.
Chromsome stability is on of the tumor-suppressive functions of ARF as well as regulation of Aurora B (zeige AURKC ELISA Kits) expression in tumors.
Using this mutant we show for the first time that AURKC has functions that do not overlap with AURKB. These functions include regulating localized CPC activity and regulating chromosome alignment and K-MT attachments at metaphase of meiosis I (Met I).
reduced accumulation of Aurora B (zeige AURKC ELISA Kits) at the inner centromere region in cells lacking Pds5B (zeige PDS5B ELISA Kits) impairs its error correction function, promoting chromosome mis (zeige AMH ELISA Kits)-segregation and aneuploidy
Aurora B (zeige AURKC ELISA Kits) and Ring1B (zeige RNF2 ELISA Kits) co-occupy active promoters in resting lymphocytes.
FBXL2 (zeige FBXL2 ELISA Kits) mediates Aurora B (zeige AURKC ELISA Kits) ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis.
Inhibitions of Aurora B (zeige AURKC ELISA Kits) and Cyclin-dependent kinase 1 (zeige CDK1 ELISA Kits) activity in vertebrate cells also have opposite effects on the timing of abscission.
Alterations in PGRMC1 (zeige PGRMC1 ELISA Kits) and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
AURKB associated with metaphase chromosomes.
Aurora B kinase is essential for furrow induction and maturation in the zebrafish embryo.
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
, aurora B
, aurora B kinase
, dAurora B
, aurora/IPL1-related kinase 2
, serine/threonine-protein kinase 12
, serine/threonine-protein kinase aurora-B
, aurora kinase B
, serine/threonine-protein kinase 12-like
, aurora 1
, aurora kinase B-Sv1
, aurora kinase B-Sv2
, aurora- and Ipl1-like midbody-associated protein 1
, aurora-related kinase 2
, protein phosphatase 1, regulatory subunit 48
, serine/threonine kinase 12
, serine/threonine-protein kinase 5
, aurora- and IPL1-like midbody-associated protein 1
, serine/threonine kinase 5
, Serine/threonine-protein kinase 12
, cellular island
, serine/threonine kinase a
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of nuclear factor kappa-B kinase subunit beta
, nuclear factor NF-kappa-B inhibitor kinase beta