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We conclude that cholera toxin inhibits colonic migrating motor complexes via release of mucosal 5-HT (zeige DDC ELISA Kits), which activates an inhibitory pathway involving 5-HT3 receptors
It was concluded that epithelial 5-HT3 receptor may function as a mediator of gut (zeige GUSB ELISA Kits) microbiota-driven change in intestinal secretion.
5HT3A receptor deletion in neuroblasts impaired speed and directionality of migration and abolished calcium spikes.
Studies with 16 arylguanidines found that their functional activity spanned a broad spectrum from superagonist to full agonist, partial agonist, and antagonist at 5-HT3 receptors; results confirm the utility of phenylguanidine as an extremely versatile scaffold in the design of 5-HT3 ligands with a "tunable" level of agonist or antagonist activity
5-HT3A-ICD is not only required but also sufficient for interaction with RIC-3
found the protein levels of AMPA (zeige GRIA3 ELISA Kits) receptor subunits (GluR1 (zeige GRIA1 ELISA Kits) and GluR2 (zeige GRIA2 ELISA Kits)) are upregulated in the amygdala and the 5-HT3 receptor is downregulated in hypothalamic regions of Socially Isolated mice.
The data of this study demonstrated that the 5-HT3 receptor is the critical target of 5-HT (zeige DDC ELISA Kits) action in exercise-induced hippocampal neurogenesis and antidepressant effects, but not in learning enhancement.
The deletion of Htr3a was related to fatal arrhythmias and sudden cardiac death during pregnancy, and its activation reversed the QT prolongation.
The results of this study suggested that 5-HT (zeige DDC ELISA Kits) released from type III cells activates gustatory nerve fibers via 5-HT3 receptors, accounting for a significant proportion of the neural taste response.
Htr3a is required for controlling the migration and laminar positioning of reelin (zeige RELN ELISA Kits)-expressing interneurons in the neocortex.
findings suggest that HTR3A mRNA expression levels were positively correlated with craving in Han Chinese alcohol-dependent patients.
Study provides structural data showing the orientation of palonosetron in a 5-HT3 receptor binding site mimic, combined with functional data in the 5-HT3 receptor, provide an explanation for the high affinity and long-lived actions of this compound. These are likely due to specific interactions formed with binding site residues, and its location as a tight and effective wedge in the binding pocket.
Studies have demonstrated that 5-HT3 receptors modulate the activity of vascular and non-vascular smooth muscles.
The HTR3A rs1062613 polymorphisms do not seem to directly influence experimental muscle pain in healthy individuals. However, women reported higher pain intensity and larger pain area than men, which might partly be attributed to genotype.
Analysis of our small Chinese sample revealed a significant association of HTR3A with bipolar disorder, but yielded no evidence of an association between HTR3B (zeige HTR3B ELISA Kits) and bipolar disorder. Furthermore, evidence for an association was found for a haplotype of HTR3A.
Alternative Viewpoint Against Breast Cancer Based on Selective Serotonin Receptors 5HTR3A and 5HTR2A Antagonists that can Mediate Apoptosis in MCF-7 Cell Line
A gene-environment interaction is revealed between childhood trauma and 5-htr3a polymorphisms.
5-HT3A receptor distal targeting in axons and dendrites depends on P2X2R expression.
Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
5-hydroxytryptamine (serotonin) receptor 3A
, 5-hydroxytryptamine receptor 3A
, 5-HT3 receptor
, 5-hydroxytryptamine receptor 3A-like
, 5-hydroxytryptamine receptor 3
, 5HT3 serotonin receptor
, serotonin receptor 3A
, serotonin-gated ion channel receptor
, 5-HT3-Al receptor
, 5-hydroxytryptamine type 3A receptor