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Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release.
Rab3a accelerates cell proliferation by increasing cyclin D1 (zeige CCND1 Proteine) expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells.
Data indicate that exocytic stimuli promote ADP ribosylation factor 6 (ARF6 (zeige ARF6 Proteine)) activation, which accomplishes exocytosis by stimulating Rab3A GTP-Binding Protein.
Five compounds which possess good inhibitory activity and may act as potential high affinity inhibitors against Rab3A active site were identified
alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity
Rab27 (zeige RAB27A Proteine) and Rab3 sequentially regulate human sperm dense-core granule exocytosis.
Myo5a (zeige MYO5A Proteine) and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a (zeige MYO5A Proteine)/Rab3A complex is involved in transport of neuronal vesicles
Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism.
Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association.
In conclusion, we have found no evidence for RAB3A conferring susceptibility on mental retardation in the Han Chinese population.
Rab3A might function as a marker of cortical granules and participates in cortical granule exocytosis in mouse eggs.
Rab3a deficiency promotes constitutive secretion and underlies selective impairment of Ca(2 (zeige CA2 Proteine))-dependent release of alpha-MSH
Rab3a deletion restores excitatory/inhibitory imbalance in synapsin II (zeige SYN2 Proteine)(-) hippocampal slices.
betaARs couple to a cAMP/Epac (zeige RAPGEF3 Proteine)/PLC (zeige HSPG2 Proteine)/Munc13-1/Rab3a/RIM1a-dependent pathway to enhance glutamate (zeige GRIN1 Proteine) release at cerebrocortical nerve terminals.
key role of Rab3a proteins control the balance between secretory vesicle biogenesis and degradation, and suggest that the ablation of this protein probably changes the nature of the reservoir of secretory vesicles available for regulated exocytosis.
Data show diminished actin plasticity in the cell processes of Rab3A knockout (KO) podocytes.
these findings suggest a crucial role of Rab3A in delivering vesicles to Ca2 (zeige CA2 Proteine)+ -dependent release sites at ribbon synapses.
Rab3A in the GTP (zeige AK3 Proteine) bound conformation prevents activity-dependent facilitation of exocytosis in bovine adrenal chromaffin cells
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
ras-related protein Rab-3C
, RAB3D, member RAS oncogene family
, RAB3A, member RAS oncogene family
, ras-related protein Rab-3A
, RAS-associated protein RAB3A
, Ras-related small GTP binding protein 3A
, SMG P25A