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Coinjection of low doses of morpholinos for beta-neurexin 1a and neuroligin 1 together or in combination with morpholinos targeting the -heparin--binding isoforms of vascular endothelial growth factor A (zeige VEGFA ELISA Kits) recapitulates the observed abnormalities
Findings support a contribution of the NLGN1 gene pathway to the neurobiological underpinnings of PTSD.
We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD (zeige ARSD ELISA Kits)) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD (zeige ARSD ELISA Kits)
the expression of NL1 and its binding partner neurexin (zeige NRXN1 ELISA Kits)-1beta was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats.
Neuroligin 1 (NL1) promotes the formation of glutamatergic synapses and mediates long-term potentiation.
NLGN1 was associated with schizophrenia in Chinese Han Populations
Increasing expression of TGF-beta1 (zeige TGFB1 ELISA Kits) protein, decreasing expressions of Ghrelin (zeige GHRL ELISA Kits), Neurexin (zeige NRXN1 ELISA Kits), and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal
Neuroligin-1 and Glu (zeige DCTN1 ELISA Kits) may represent new markers of ganglion cells, whose expression may correlate with the pathogenesis, diagnosis, differential diagnosis or classification of Hirschsprung's disease.
Results indicate that the neurexin (zeige NRXN1 ELISA Kits) and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 (zeige DISC1 ELISA Kits) function, thus contributing to a better understanding of the pathology of schizophrenia.
Monitoring the attachment and detachment of neurexin (Nrx (zeige NRXN1 ELISA Kits))-coated quantum dots measures the rates of neurexin (Nrx (zeige NRXN1 ELISA Kits))/neuroligin interaction in the hippocampus.
We identified a cluster of single nucleotide polymorphisms at the NLGN1 locus showing significant association with BP variability. Follow-up analyses did not support an association with risk of ischemic stroke and its subtypes
Co-expression of gamma-Pcdhs inhibits the ability of Nlg1 to increase spine density and to induce presynaptic differentiation in hippocampal neurons in vitro.
The alternatively spliced segment 4 (AS4) of NRX genes (Nrxn) is a critical element in selective trans-synaptic interactions. This study evaluated the synaptogenic receptor activity of NL1/2/3 isoforms in a neuron-fibroblast co-culture system, in which the Nrxn AS4 segments are manipulated using SLM2, a selective and dominant regulator of AS4 splicing.
We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD (zeige GUSB ELISA Kits)) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD (zeige GUSB ELISA Kits)
The results indicate that Nrx2alpha and NL1 (zeige MMEL1 ELISA Kits) are targets of Abeta (zeige APP ELISA Kits) oligomers and that prevention of this interaction reduces the deleterious impact of Abeta (zeige APP ELISA Kits) oligomers on synapses and cognition.
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.
Study shows that astrocyte-secreted hevin is a trans-synaptic linker that bridges presynaptic NRX1alpha with postsynaptic NL1B. This way, hevin organizes both pre- and postsynaptic specializations and aligns them across the synapse.
Results are indicative of an altered immediate response of the brain to peripheral stimulation in Nlgn1 KO mice, and suggest a role for NLGN1 in the regulation of cerebrovascular responses
the R451C mutation in the Nlgn3 (zeige NLGN3 ELISA Kits) gene, associated with autism spectrum disorder in humans, confers resistance to induced seizures
This study provided first evidence that NL1 (zeige MMEL1 ELISA Kits) is essential for normal excitatory transmission and long-term synaptic plasticity in the hippocampus of intact animals.
NLGN1 and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 deletion causes an aberrant VE-cadherin (zeige CDH5 ELISA Kits), laminin and alpha6 integrin distribution in vessels
transmembrane ligand for neurexins\; involved in development and maturation of synaptic connections
, neuroligin I
, neuroligin 1 isoform A1A2B