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These observations indicate neuronally expressed RHGF-2 is an essential RHO-1 specific RhoGEF (zeige ARHGEF11 ELISA Kits) that binds most strongly to MPZ-1 PDZ domain (zeige INADL ELISA Kits) eight and is required for wild-type C. elegans morphology and growth.
results suggest that the ARR-1-MPZ-1-DAF (zeige CD55 ELISA Kits)-18 complex functions to regulate DAF-2 signaling in vivo and provide insight into a novel mechanism by which arrestin (zeige SAG ELISA Kits) is able to regulate IGF-1R (zeige IGF1R ELISA Kits) signaling and longevity
These studies suggest that the SER-1 (zeige JAG1 ELISA Kits)/MPZ-1 interaction facilitates SER-1 (zeige JAG1 ELISA Kits) mediated signaling.
This evidence points to a role of MUPP1 as a membrane raft-associated molecular organizer, suggesting that mammalian spermatozoa may use a scaffolding protein and membrane subdomains to organize components involved in the process of acrosomal exocytosis.
Phenotypic spectrum of congenital hydrocephalus (zeige FOXC1 ELISA Kits) is associated with 5 recessive MPDZ alleles.
The replication association of rs1324183 (MPDZ-NF1B (zeige NFIB ELISA Kits)) with KC in our population and the results, which are identical to those in different populations, suggest that rs1324183 (MPDZ-NF1B (zeige NFIB ELISA Kits)) is a common genetic risk for Keratoconus.
MUPP-1 controls the PALS-1 (zeige MPP5 ELISA Kits)/PATJ (zeige INADL ELISA Kits) complex levels at the post-translational level.
Our data strongly support the candidacy of MPDZ as a novel congenital hydrocephalus (zeige FOXC1 ELISA Kits) disease gene.
The data indicates potential association between variation in mpdz NMDA dependent AMPA (zeige GRIA3 ELISA Kits) trafficking and alcohol dependence.
Results indicate that the coxsackievirus and adenovirus receptor (zeige CXADR ELISA Kits) interacts with multi-PDZ domain protein 1 (MUPP1) and is involved in MUPP1 recruitment to the tight junction.
The results revealed prominent MUPP1 expression which was (zeige INADL ELISA Kits)restricted to the apical acrosomal region and, most notably, to the equatorial segment of the acrosome[MUPP1]
MUPP1 binds to the G protein-coupled MT(1 (zeige MT1A ELISA Kits)) melatonin receptor and directly regulates its G(i)-dependent signal transduction
An interaction between the human somatostatin receptor 3 (zeige SSTR3 ELISA Kits) and the multiple PDZ protein MUPP1 was identified.
Exploratory haplotype and single nucleotide polymorphisms association analyses suggest a possible association between the MPDZ gene and alcohol dependence but not alcohol withdrawal seizures.
Variants of the multiple PDZ domain (zeige INADL ELISA Kits) gene Mpdz may contribute to the observed inter-strain variability in opioid tolerance and opioid-induced hyperalgesia by virtue of changes in the level of their expression.
MUPP1-PDZ4 domain contained three alpha-helices and six beta-strands in the core. The GLGI motif, L562/A564 on the beta-strand B, and H605/V608/L612 on the alpha-helix B formed a PDZ (zeige INADL ELISA Kits) binding pocket which could bind to the C-terminal of the binding partners.
Increased MPDZ expression decreased the severity of ethanol withdrawal, while decreased MPDZ expression increased ethanol withdrawal severity. Decreased MPDZ expression was associated with increased voluntary ethanol consumption.
neurexin 1 (zeige NRXN1 ELISA Kits) interaction with multi-PDZ domain protein (zeige INADL ELISA Kits) MUPP1
Our results confirm that Mpdz is a quantitative trait gene for alcohol withdrawal and demonstrate that its expression in the caudolateral substantia nigra pars (zeige EPRS ELISA Kits) reticulata is crucially involved in risk for alcohol withdrawal.
despite their terminal sequence diversity all three GABA transporter PDZ (zeige INADL ELISA Kits) motifs interacted with MUPP1 domain 7
Cadm1 (zeige CADM1 ELISA Kits) specifically interacts with Mupp1, and may form a ternary complex with Mupp1-GABBR2 (zeige GABBR2 ELISA Kits) in the cerebellum.
both AF6 (zeige MLLT4 ELISA Kits) and MUPP1 are associated with Cx36 (zeige GJD2 ELISA Kits)-containing interneuronal gap junctions that form electrical synapses in adult rodent brain
CaMKIIalpha (zeige CAMK2 ELISA Kits) interacts with MUPP1 in spermatozoa to prevents spontaneous acrosomal exocytosis.
5-HT2C R interaction with MUPP1 is dynamically regulated by phosphorylation at Ser458
may play a role in G-protein coupled, 5-HT2C receptor-activated phosphoinositide-linked second messenger signaling
Multiple PDZ domain protein family member (mpz-1)
, multiple PDZ domain protein
, Multiple PDZ domain protein
, multiple pdz domain protein
, multi-PDZ domain protein 1