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This study showed the lower GluK4 mRNA levels in pregnant women.
Data suggest the involvement of glutamate receptor, ionotropic, kainate 4 protein (GRIK4) in treatment-resistant depression (TRD) and in the risk of developing psychotic symptoms during depressive episodes.
Subjects possessing the C allele or CC genotype of the GRIK4 polymorphism rs1954787 are more likely to respond to antidepressant treatment.
The deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells.
Activation of kainate receptors could serve as a novel mechanism for enhancing B cell activation (zeige BLNK ELISA Kits) and immunoglobulin production.
The GRIK4 single nucleotide polymorphism (rs12800734) shows a strong association with disease remission in antidepressant treatment.
Cytogenetic and genetic findings provide molecular evidence for common etiologies for schizophrenia and and bipolar disorder and further support the 'glutamate (zeige GRIN1 ELISA Kits) hypothesis' of psychotic illness.
An insertion/deletion (indel) variant in the 3' untranslated region (3'UTR (zeige UTS2R ELISA Kits)) of the GRIK4 gene in subjects carrying the protective bipolar disorder haplotype was found.
This report provides the first evidence that genetic variation in the GRIK4 gene modulates hippocampal function.
The cytoplasmic domain of the GluK2 (zeige GRIK2 ELISA Kits) low-affinity subunit stabilizes kainate receptors at synapses. In contrast, the extracellular domain of the GluK4/5 high-affinity subunit synergistically controls the synaptic specificity of kainate receptors through interaction with C1q-like proteins.
This study demonstrated that mice overexpressing grik4 to directly address circuit dysfunctions associated with ASDs and test specific treatments of autism-related behaviors.
we found that GluK4 is a key mediator of excitotoxic neurodegeneration
This study demonstrated a clear anxiolytic and antidepressant phenotype associated with ablation of Grik4 and a parallel disruption in hippocampal plasticity.
the KA1 KAR (zeige HSD17B12 ELISA Kits) subunits are expressed in the SG of the Vc in mice and that the expression level of the KA1 KAR (zeige HSD17B12 ELISA Kits) subunit decreases gradually with postnatal development.
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.
glutamate receptor, ionotropic, kainate 4
, ionotropic glutamate receptor subunit KA1
, excitatory amino acid receptor 1
, glutamate receptor KA-1
, glutamate receptor KA1
, glutamate receptor ionotropic, kainate 4
, glutamate receptor, ionotropic kainate 4
, kainate receceptor